{"title":"对DNA杂交体施加最大的拉力","authors":"Pierre-Gilles de Gennes","doi":"10.1016/S1296-2147(01)01287-2","DOIUrl":null,"url":null,"abstract":"<div><p>We discuss theoretically the force <em>F</em> between two colloidal particles, each of them carrying one single strand DNA. The two strands are complementary only on a finite sequence of (ℓ) consecutive base pairs. We define an adjustment length <em>ϰ</em><sup>−1</sup> (a few base pairs); in the adjustment regions near both ends of the paired region, the tension is still mainly on one single strand. But in the central part (for ℓ><em>ϰ</em><sup>−1</sup>) the two backbones are equally loaded. This leads to a rupture force <em>F</em><sub><em>c</em></sub> increasing linearly with ℓ for ℓ<em>ϰ</em><1, and saturating for ℓ<em>ϰ</em>>1.</p></div>","PeriodicalId":100307,"journal":{"name":"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics","volume":"2 10","pages":"Pages 1505-1508"},"PeriodicalIF":0.0000,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1296-2147(01)01287-2","citationCount":"37","resultStr":"{\"title\":\"Maximum pull out force on DNA hybrids\",\"authors\":\"Pierre-Gilles de Gennes\",\"doi\":\"10.1016/S1296-2147(01)01287-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We discuss theoretically the force <em>F</em> between two colloidal particles, each of them carrying one single strand DNA. The two strands are complementary only on a finite sequence of (ℓ) consecutive base pairs. We define an adjustment length <em>ϰ</em><sup>−1</sup> (a few base pairs); in the adjustment regions near both ends of the paired region, the tension is still mainly on one single strand. But in the central part (for ℓ><em>ϰ</em><sup>−1</sup>) the two backbones are equally loaded. This leads to a rupture force <em>F</em><sub><em>c</em></sub> increasing linearly with ℓ for ℓ<em>ϰ</em><1, and saturating for ℓ<em>ϰ</em>>1.</p></div>\",\"PeriodicalId\":100307,\"journal\":{\"name\":\"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics\",\"volume\":\"2 10\",\"pages\":\"Pages 1505-1508\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1296-2147(01)01287-2\",\"citationCount\":\"37\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1296214701012872\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes Rendus de l'Académie des Sciences - Series IV - Physics-Astrophysics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1296214701012872","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
We discuss theoretically the force F between two colloidal particles, each of them carrying one single strand DNA. The two strands are complementary only on a finite sequence of (ℓ) consecutive base pairs. We define an adjustment length ϰ−1 (a few base pairs); in the adjustment regions near both ends of the paired region, the tension is still mainly on one single strand. But in the central part (for ℓ>ϰ−1) the two backbones are equally loaded. This leads to a rupture force Fc increasing linearly with ℓ for ℓϰ<1, and saturating for ℓϰ>1.
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