瑞德西韦和地塞米松:两种抗严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染的候选药物

Y. Sikandar, Ilora Kheya, R. Noor
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引用次数: 5

摘要

为了缓解由严重急性呼吸系统综合征冠状病毒引起的COVID-19大流行,正在进行大量基于药物设计、计算机研究、细胞培养/动物模型研究和临床试验的研究,以寻找合适的治疗药物和开发疫苗2。虽然目前还没有疫苗,但一些潜在的抗病毒药物已被重新利用,包括瑞德西韦、氯喹/羟氯喹、利巴韦林、法匹拉韦、头孢anthine和洛匹那韦/利托那韦,其中瑞德西韦因其多靶点作用而被广泛接受用于治疗目的。此外,免疫抑制剂地塞米松也在进化,在一定程度上保护了COVID-19重症患者的死亡。因此,目前的审查强调瑞德西韦和地塞米松是目前大流行的成功补救措施,并发现了地塞米松可能的作用方式。
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Remdesivir and Dexamethasone: The Two Eligible Candidate Drugs Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) Infection
Lots of research based on drug designing as well as in silico study, cell culture/animal model study, and the clinical trials are being conducted perceive the suitable therapeutic drugs and to develop vaccines in order to alleviate the ongoing COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2. Although there are still no vaccines, some potential antiviral drugs have been repurposed including remdesivir, chloroquine/hydroxychloroquine, ribavirin, favipiravir, cepharanthine, and lopinavir/ritonavir, of which remdesivir has been mostly accepted for the treatment purpose because of its multitarget actions. Besides, the immunosuppressive agent, dexamethasone, evolved with the capacity to protect the severely affected COVID-19 patients from death to some extent. The current review, thus, emphasized on both remdesivir and dexamethasone as the successful remedies for the ongoing pandemic and detected the possible mode of action of dexamethasone.
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