新西兰宫颈癌-细胞学检查失败?- - - - - -

G. H. Green
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引用次数: 0

摘要

新西兰考虑了浸润性宫颈癌的发病率(1948年至1977年)和死亡率(1941年至1978年),以及原位癌的报告率和细胞学筛查率,以发现从当前宫颈癌的一般生物学模型(即正常上皮结构不典型化)中可以做出的预测是否可验证。结果显示,20-34岁妇女的死亡率和发病率显著上升,老年妇女的发病率几乎没有显著下降,早期侵袭性癌症的比例没有上升,而在随后几年报告的原位癌的数量大幅增加,但没有增加筛查来解释这一点,这使人们对模型的有效性和细胞学筛查在宫颈癌控制中的价值产生怀疑。
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Cervical Cancer in New Zealand —A Failure of Cytology?—
Incidence rates (1948 – 1977) and mortality rates (1941 – 1978) for invasive cervical cancer, together with reporting rates for in situ cancer and cytology screening rates, are considered for New Zealand to find whether the predictions which can be made from the current general biological model of cervical cancer, i.e. normal epithelium ⇄ dysplasia ⇄ carcinoma in situ invasive cancer, are verifiable or not. The results, notably significant rises in mortality and incidence in women 20–34 years old, barely significant falls in incidence in older women, a failure of the proportion of early-stage invasive cancers to rise, and an enormous increase in reported in situ cancer in the later years without an increase in screening to account for this, cast doubt on the validity of the model and the value of cytological screening in the control of cervical cancer.
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