特别评论:瞄准目标:靶向药物和个性化医疗

Bibiana I. Ferreira, R. Hill, W. Link
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引用次数: 11

摘要

摘要所有药物都有分子靶点;然而,这并不意味着它们是靶向治疗。只有通过与疾病特异性分子的相互作用,药物才能被归类为靶向治疗药物。这通常没有明确的定义,可能涉及几种不同的治疗方式,如基因组靶向治疗、免疫检查点治疗或药代动力学靶向治疗。为了建立一个精确的靶向治疗概念,了解药物是如何被发现的,以及我们对疾病机制的快速扩展的知识是如何推动现代药物发现和开发的根本概念变化的,这一点至关重要。结合个体患者水平上对疾病的日益详细的分析,我们认为现在是非常及时的考虑过去和现在开发新药所涉及的方法,并讨论与靶向治疗和个性化医疗相关的范式转变和基本概念。
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Special Review: Caught in the Crosshairs: Targeted Drugs and Personalized Medicine
Abstract All drugs have molecular targets; however, this does not mean that they are targeted therapeutics. Only by the interaction with a disease-specific molecule can the drug be classified as a targeted therapeutic. This is often not clearly defined and might refer to several different therapeutic modalities such as genomically targeted therapy, immune checkpoint therapy, or pharmacokinetic targeting. To develop a precise concept of targeted therapy, it is crucial to understand how drugs were discovered and how our rapidly expanding knowledge concerning disease mechanism is driving a fundamental conceptual change in modern drug discovery and development. In combination with the increasingly detailed analysis of disease at an individual patient level, we believe that it is very timely to consider the past and current approaches involved in the development of new medicines and to discuss the paradigm shift in and basic concepts associated with targeted therapies and personalized medicine.
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