Anti-Urolithiatic Activity of Filipendula ulmaria Leave Extracts in Male Albino Rats

Filipendula ulmaria L. is a perennial herb that can be found in regions with higher humidity in Asia, and Europe. The herb is used medicinally as drugs for several purposes such as facilitating renal elimination functions and many other biological activities. Therefore, the present study was focus on the anti-Urolithiatic activity of Filipendula ulmaria leaf extracts using Albino rats as a model. The influence of oral administration of aqueous, methanolic and ethanolic extracts of Filipendula ulmaria leaves on accumulated calcium oxalate urolithiasis has been investigated. Nephrolithiasis was induced in the rats by oral administration of ethylene glycol (0.75%) in drinking water for 28 days. Animals were divided into nine groups, each containing six rats. Group 1 received purified water as negative control; group 2 received ethylene glycol in drinking water; group 3 received cystone as curative agent, groups 4-9 received Filipendula ulmaria extracts in dosages of 100 and 200 mg/kg body weight, respectively. The aqueous and methanolic Leaf-extracts showed significant reduction in the urine parameters compared to ethanolic extracts. However, using the cystone showed highest reduction rate compared to the leaf-extracts using different solvents. Cystone also recorded higher impact on the serum parameters compared to the extract used. The results revealed that the Filipendula ulmaria leaf extracts have anti-urolithiatic activity against ethylene glycol-induced calcium oxalate urolithiasis in male albino rats.