对FIGO和ADA的审查,WHO, IADPSG低资源环境GDM指南和DIPSI与MOHFW印度政府的整合指南

Rajesh Jain, S. Olejas, Lee Sam Goo, N. Bhavatharinin, Ashish S. Dengra, R. Shoghli, S. Davey, Rachna Jain
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摘要

OGTT是在孕妇空腹或非空腹摄入75克葡萄糖(一水葡萄糖无水)2小时后测量血浆葡萄糖。对于诊断妊娠糖尿病(GDM),印度指南(DIPSI测试)很简单,可以在资源匮乏的环境中轻松完成,那里有大量孕妇去进行ANC检查。由于胎盘激素分泌增加,胰岛素的作用减弱(胰岛素抵抗),GDM的严重程度增加。GDM的其他危险因素包括:老年人、体重指数升高、肥胖、孕期体重增加、家族糖尿病史、死胎或以前分娩的先天性异常。以前认为妊娠期糖尿病是短暂的,妊娠后会消退,但是,患有高血糖的孕妇在随后的妊娠中发生GDM的风险更高,大约一半有GDM病史的妇女在分娩后5至10年内会发生II型糖尿病。DIPSI简单检测方案得到了国家卫生特派团(GOI)关于GDM指南的认可,也得到了FIGO关于在南亚使用HIP指南的认可。该地区的斯里兰卡、巴基斯坦和孟加拉国遵循了这一检测议定书。印度泰米尔纳德邦和北方邦分别于2007年和2016年启动了一项普遍妊娠糖尿病计划,在大多数医疗机构中通过使用MNT、二甲双胍和胰岛素检测和管理妊娠糖尿病,覆盖所有孕妇。为实施印度北方邦迄今为止最大的GDM计划,约有28,000名ANM获得了血糖仪,试纸和75克葡萄糖包。
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Review of FIGO & ADA, WHO, IADPSG Guidelines for GDM for Low Resource Setting and Integration of DIPSI with MOHFW Govt of India, Guidelines
OGTT is performed in pregnant women by measuring the plasma glucose in fasting or non-fasting after 2-hour ingesting 75 grams of glucose (Monohydrate Dextrose Anhydrous). For diagnosing gestational diabetes (GDM) Indian Guidelines (DIPSI Test) are simple and can be done easily in low resource setting where large number of pregnant women visit for ANC check-up. The severity of GDM increases because of the action of insulin is diminished (insulin resistance) due to raised hormone secretion by the placenta. Other risk factors for GDM are being elderly, increased BMI, or obesity, weight gain in pregnancy, history of diabetes in family, stillbirth or a congenital abnormality in previous deliveries. GDM has previously been considered to be transient during pregnancy and resolve after pregnancy but, pregnant women with hyperglycaemia are at higher risk of developing GDM in subsequent pregnancies and about half of the women with a history of GDM will develop type II Diabetes within five to ten years after delivery. DIPSI simple testing protocol is endorsed by the National Health Mission (GOI) Guideline on GDM, and also endorsed by the FIGO guideline on HIP for use in South Asia. This testing protocol has been followed by Sri Lanka, Pakistan and Bangladesh in the region. Tamil-Nadu state and Uttar Pradesh states in India launched a Universal GDM Program in 2007 and 2016 respectively, covering all pregnancies by testing and managing GDM with MNT, Metformin and Insulin in most of health care facilities. Around 28,000 ANM have been given glucometers, strips, glucose 75 gm packets for implementation of the largest GDM program in Uttar Pradesh, India to date.
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