激光辅助孵化微调(LAHA)在体外受精周期2个年龄组

Beatriz Amorocho , Marta Mollá , David Gumbao , Julián Marcos , Ana Sánchez , Laura Fernández , María Nicolás , José Landeras , Gloria Calderón
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引用次数: 0

摘要

根据妊娠率、着床率和流产率对激光辅助稀疏孵化(LAHT)的效果进行回顾性研究。该研究根据患者年龄分为两组,分别接受体外受精/ICSI治疗。38岁及以上的女性共进行308个周期,随机分为两组;A组:不进行LAHT的154个周期(No-LAHT), B组:剩余的154个周期,所有前胚胎移植均进行LAHT。这两组再按年龄细分为4组:No-LAHT 38、39岁、LAHT 38、39岁、No-LAHT≥40岁、LAHT≥40岁。总体结果显示,No-LAHT vs LAHT的妊娠和着床率(29.9 vs 37.7%, P = 0.185;19.6 vs 27.1%, P = 0.051。按年龄组划分,38岁和39岁No-LAHT组和LAHT组的妊娠和着床率差异有统计学意义:32.1 vs 46.9%, P = 0.033;20.8% vs 35.0%, P = 0.004。本研究显示了LAHT技术在38岁和39岁患者组中的有效性,在妊娠和着床率方面表现出最佳效果。在超过40年的患者中,未发现分离LAHT(无PGD)的有益效果,这可能是由于该患者组中存在胚胎染色体异常。
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Láser assisted hatching afinamiento (LAHA) en ciclos de fecundación in vitro en 2 grupos de edades

A retrospective study was conducted to evaluate the effect of the Laser Assisted Hatching by Thinning (LAHT) according to the results of the pregnancy rate, implantation rate and miscarriage rate. The study was carried out with two groups of patients who had undergone treatment by IVF/ICSI and according to patient age.

A total of 308 cycles were performed on women of 38 years or more, randomly divided in two groups; group A:154 cycles without LAHT (No-LAHT), and group B: the remaining 154 cycles in which all pre-embryos were transferred were subjected to LAHT. These two groups in turn were further subdivided into 4 groups according to the age: No- LAHT 38 and 39 years, LAHT 38 and 39 years, No-LAHT  40 years, and LAHT  40 years.

The overall results showed pregnancy and implantation rates of No-LAHT vs LAHT (29.9 versus 37.7%, P = .185; 19.6 versus 27.1%, P = .051 respectively. The results by age group showed significant differences in pregnancy and implantation rates in 38 and 39 years No-LAHT and LAHT groups: 32.1 versus 46.9%, P = .033; 20.8 vs 35.0%, P = .004, respectively.

This study shows the effectiveness of the LAHT technique in women of the 38 and 39 years group of patients, showing the best results in pregnancy and implantation rates.

No beneficial effect of isolated LAHT (no PGD) was found from greater than 40 years, which could be due to the presence of embryonic chromosomal abnormalities in this patient group.

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