虾壳壳聚糖治疗犬四肢创面1例

B. K. Tekelioglu, M. Celik, Aygül Küçükgülmez
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引用次数: 2

摘要

本病例报告的目的是证明壳聚糖作为外用药物治疗严重感染的犬肢体伤口的有效性。这只狗被一辆公共汽车撞了,出现了严重的摩擦伤,并伴有双侧髋关节和四肢骨折。术后观察局部感染和全身感染。狗对标准治疗方案没有反应,健康状况越来越差。由于感染和组织爆发,再生缝合线不能固定组织。从虾壳废弃物中提取壳聚糖样品。壳聚糖研磨后用于局部治疗皮肤和后肢开放性和重度混合感染创面并伴有发热和犬冠状病毒腹泻。决定利用壳聚糖作为生物屏障和抗生物作用于受损和爆发的组织。宏观观察结果表明,壳聚糖具有促进自然凝血和吸收炎症液的作用。显微镜观察结果显示,在创面愈合早期,局部使用壳聚糖可加速多形态核白细胞(PMN)的浸润。每日观察伤口愈合情况。本兽医实践伤口治疗结果表明,壳聚糖能有效地局部治疗犬开放性感染伤口,并在4周内促进肉芽肿的形成。
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Canine Extremity Wound Treatment with Chitosan Extracted from Shrimp Shells: A Case Report
The aim of this case report was to demonstrate the effectivity of chitosan as topical agent on the treatment of severely infected canine extremity wound. The dog was hit by a bus and presented severe friction wounds accompanying with bilateral hip and extremity fractures. Local and generalized infections were observed on the post operational period. The dog was unresponsive to the standard therapeutic protocols and health status was getting worsened. The regenerative sutures did not hold the tissues because of the infection and the tissue eruption. Chitosan samples were extracted from shrimp shell wastes. The milled form of chitosan was topically used to treat the open and heavily mix infected wound areas located at skin and rear extremities accompanying with fever and Canine coronavirus diarrhea. It was decided to use the chitosan as a bio barrier and anti-bio affect over the damaged and erupted tissues. Macroscopic findings indicated chitosan promoted the natural blood clotting and absorbed the inflammation fluid. Microscopic findings indicated the infiltration of polymorph nuclear leukocytes (PMN) accelerated with the topical use of chitosan in the early phase of wound healing. The wound healing was observed daily. This veterinary practice wound treatment result indicated that chitosan is effective to medicate topically the canine open and mix infected wounds with bacteria and viruses and promotes the granulomatosis in four weeks period.
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