内源性血管活性介质在门脉高压胃粘膜防御中的作用

Paula R. S. Camara
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引用次数: 1

摘要

炎症介质可以通过有效影响粘膜防御的各种组成部分来改变粘膜的完整性,这些组成部分是多种因素的组合,这些因素使粘膜能够承受暴露于不同类型的pH范围、温度和渗透力的物质、具有洗涤剂性质的溶液(胆汁)和细菌产物,这些物质可以激活局部和全身炎症反应。另一方面,我们前期研究表明不同胃内pH范围对门脉高压大鼠胃损伤有保护或诱导作用。当粘膜发生损伤时,病变的修复可以迅速激活,限制了有害物质(细菌产物)与体循环接触的可能性。胃黏膜对损伤的抵抗力最终取决于存在于粘膜腔内的防御因子和侵袭因子之间的平衡。粘膜防御的各种成分可受到炎症介质的影响。这些介质包括前列腺素、一氧化氮、内皮素、细胞因子、自由基、神经肽和幽门螺杆菌。这些介质有助于调节粘膜防御和胃粘膜损伤的发病机制,并将在本文中更详细地描述。
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Endogenous vasoactive mediators in defense of portal hypertensive gastric mucosa
The inflammatory mediators can alter the integrity of mucosa by effectively influencing the various components of the mucosal defense, which are a combination of factors that allow the mucosa withstand exposure to substances with different types of pH range, temperature, and osmosis, solutions with detergent properties (bile) and bacterial products that can activate local and systemic inflammatory reactions. On the other hand, our previous research showed that different kinds of intragastric pH range can protect or induce gastric damage in portal hypertensive rats. When damage occurs to the mucous membrane, repair of the lesion can be activated quickly, limiting the possibility of harmful substances (bacterial products) coming into contact with the systemic circulation. The resistance of the gastric mucosa to injury depends, ultimately, on a balance between defensive factors and aggressive factors present in the lumen of the mucosa. Various components of mucosal defense can be influenced by inflammatory mediators. Some of these mediators are prostanoids, nitric oxide, endothelins, cytokines, free radicals, neuropeptides and Helicobacter pylori. These mediators contribute to both the modulation of mucosal defense and the pathogenesis of gastric mucosal injury, and will be described a little more detail in the present paper.
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