双炔诺孕素和醋酸左炔诺列酯对子宫内膜异位症小鼠血清干扰素-Ɣ水平影响的比较

IF 0.2 Q4 PHARMACOLOGY & PHARMACY Asian Journal of Pharmaceutical Research and Health Care Pub Date : 2023-08-11 DOI:10.55561/ajhr.v2i2.111
Ikatan Dokter, Indonesia Wilayah, Jawa Timur, María Antonia, Barbara Batu Mali, Siskanita Nur Fitriana, S. Sutrisno, H. Khotimah, Wayan Arsana Wiyasa, W. Indrawan
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摘要

简介:子宫内膜异位症是一种医学状况,在子宫外有类似子宫内膜的组织异常生长。它可以引起疼痛和/或不孕的症状。目前的医学治疗侧重于降低雌二醇水平或刺激黄体酮反应。最有效的医疗选择之一是使用GnRH类似物。孕酮对子宫内膜异位症间质细胞有直接的抗炎作用。然而,这些药物对IFN-Ɣ的抗炎作用的比较以前没有研究过。因此,本研究旨在比较Dienogest和Leuprolide Acetat在小鼠模型中降低IFN-Ɣ的作用。材料与方法:本研究采用单试验后对照组设计,共分为阴性对照组、阳性对照组和2个治疗组,其中一组给药量为0.0052 mg / d,连用14天;另一组给药量为0.00975 mg / d,连用14天。采用酶联免疫吸附试验(ELISA)测定血清IFN-Ɣ水平。随后使用IBM SPSS 25对数据进行单因素方差分析。结果:本研究表明醋酸左连络酯能显著降低血清中IFN-Ɣ的水平,而地诺孕素却能提高血清中IFN的水平。结论:在子宫内膜异位症(小家鼠)小鼠模型中,醋酸左连络酯能有效降低IFN-Ɣ(促炎)水平。相反,Dienogest增加了子宫内膜异位症小鼠模型中IFN-Ɣ(抗炎)的水平。
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Comparison of the Effects of Dienogest and Leuprolide Acetat on Serum Interferon (IFN-Ɣ) Levels in a Mouse Model of Endometriosis (Mus musculus)
Introduction: Endometriosis is a medical condition in which there is abnormal growth of tissue resembling the endometrium outside the uterus. It can cause symptoms of pain and/or infertility. The current medical therapy focuses on reducing estradiol levels or stimulating progesterone response. One of the most effective options for medical treatment is the use of GnRH analogs. Dienogest have a direct anti-inflammatory effect on endometriotic stromal cells. However, a comparison of the anti-inflammatory effects of these drugs on IFN-Ɣ has not been previously investigated. Therefore, this study aims to compare the effects of reducing IFN-Ɣ by both Dienogest and Leuprolide Acetat in a mouse model. Material and Methods: This study employed a post-test only control group design and involved 4 groups, namely the negative control group, positive control group, and two treatment groups: one group administered Dienogest at a dosage of 0.0052 milligrams per day for 14 days, and the other administered Leuprolide Acetat at a dosage of 0.00975 milligrams once every 5 days for a period of 14 days. Serum IFN-Ɣ levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). The data were subsequently analyzed using IBM SPSS 25 with One-Way ANOVA test. Results: This study demonstrated that Leuprolide Acetat significantly decreased serum levels of IFN-Ɣ, whereas Dienogest actually increased the levels . Conclusion: In a mouse model of endometriosis (Mus musculus), Leuprolide Acetat effectively reduced the levels of IFN-Ɣ (pro-inflammatory). Conversely, Dienogest increased the levels of IFN-Ɣ (anti-inflammatory) in the mouse model of endometriosis.
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