反义寡核苷酸的医学应用综述

Kavya Pandiri, M. Samad, Nadeem Abbas Gulamus, Hajera Khanam
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引用次数: 0

摘要

由于DNA和RNA生理学知识的进步,反义技术已成为一种快速且可想象的高通量抑制基因的方法。近年来,反义寡核苷酸治疗在递送策略上的局限性已被克服。反义寡核苷酸治疗有效地应用于广泛的治疗领域。随着反义寡核苷酸的不断批准,人们越来越热衷于增加这些化合物在治疗各种感染方面的应用。这篇简短的综述对反义技术的应用、如何在治疗上加以利用以及目前发展新的反义寡核苷酸疗法的努力进行了深远的理解,这些疗法将为各种疾病的治疗增加一种新的治疗方法。
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Medicinal Applications of Antisense Oligonucleotides: A Review
Antisense technology has emerged as a fast and conceivably high-throughput method for repressing genes due to advancement in knowledge about DNA and RNA physiology. The limitations of antisense oligonucleotide therapy in delivery strategies have been overcome in recent years. Antisense oligonucleotide treatment was effectively applied towards targeting a wide range of therapeutic areas. With ongoing approvals of antisense oligonucleotides, there is an expanding enthusiasm for increasing the utilization of these compounds for curing various infections. This short survey gives a far-reaching comprehension of applications of antisense technology, how they can be utilized therapeutically, and current endeavors to grow new antisense oligonucleotide treatments that will add a forthcoming therapeutic approach for the treatment of various diseases.
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