妊娠状况对新冠肺炎患者临床症状的影响

Anita Rahmawati, Pertiwi Perwiraningtyas
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摘要

与未怀孕妇女相比,孕妇的生理适应可能会增加出现更严重新冠肺炎症状的风险,但没有太多支持数据。这项研究的目的是比较怀孕和未怀孕的Covid-19阳性妇女的严重程度类别。该研究采用回顾性方法进行,从2020年11月至2021年12月被检测为COVID-19阳性的患者病历中获取二次数据。该研究的样本量包括67名怀孕的女性COVID-19患者和67名未怀孕的女性。样本采用随机抽样法。将新冠肺炎临床症状分为5类(无症状、轻度、中度、重度/重度肺炎、危重)。采用Mann Whitney检验对数据进行分析。结果显示,暴露于新冠病毒的孕妇组与非孕妇组的临床症状类别差异有统计学意义,p=0.000 (p< 0.05)。妊娠期新冠肺炎患者的临床症状比未妊娠期患者更严重。这可能是由于怀孕期间凝血和纤溶因子水平升高引起的。希望对新冠肺炎患者特别是孕妇的处理更加细致,避免出现更严重的临床症状。
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Clinical Symptoms on Covid-19 Patient According to Pregnancy Status
Physiological adaptation in pregnant women may increase the risk of more severe symptoms of Covid-19 than women who are not pregnant but there was not much supporting data. Aim of this study was to compare the severity category between women who are pregnant and not pregnant with positive Covid-19. The study was conducted using a retrospective approach which obtained secondary data from patient medical records after being tested positive for COVID-19 from November 2020 to December 2021. Sample size for the study consisted of 67 women COVID-19 patients who were pregnant and 67 women who were not pregnant. Samples were taken by accidental sampling. Categorization of clinical symptoms of COVID-19 was divided into 5 categories (no symptoms, mild, moderate, severe/severe pneumonia, critical). Data were analysis with the Mann Whitney test. Results showed that there were significant differences in the categories of clinical symptoms between groups of pregnant women and groups of non-pregnant women who were exposed to Covid-19 with a value of p=0.000 (p<0,05). Clinical symptoms in Covid-19 patients who are pregnant more severe than women who are not pregnant. This may be caused by increased levels of coagulation and fibrinolytic factors during pregnancy. It is hoped that the handling of Covid-19 patients, especially pregnant women, will receive more detailed attention to avoid the appearance of more severe clinical symptoms.
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