疼痛灾难预测骨科手术后阿片类药物和医疗保健使用

D. Rhon, Tina A. Greenlee, Patricia K. Carreño, Jeanne C. Patzkowski, K. Highland
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Self-reported and medical record data included presurgical Pain Catastrophizing Scale (PCS) scores, surgical success expectations, opioid use, and pain interference duration. Results: Complete outcomes were analyzed for 240 participants with a median age of 42 years (34% were female, and 56% were active-duty military service members). In the multivariable generalized additive model, greater presurgical days’ supply of opioids (F = 17.23, p < 0.001), higher pain catastrophizing (F = 1.89, p = 0.004), spine versus lower-extremity surgery (coefficient estimate = 1.66 [95% confidence interval (CI), 0.50 to 2.82]; p = 0.005), and female relative to male sex (coefficient estimate = −1.25 [95% CI, −2.38 to −0.12]; p = 0.03) were associated with greater 12-month postsurgical days’ supply of opioids. Presurgical opioid days’ supply (chi-square = 111.95; p < 0.001), pain catastrophizing (chi-square = 96.06; p < 0.001), and lower extremity surgery (coefficient estimate = −0.17 [95% CI, −0.24 to −0.11]; p < 0.001), in addition to age (chi-square = 344.60; p < 0.001), expected recovery after surgery (chi-square = 54.44; p < 0.001), active-duty status (coefficient estimate = 0.58 [95% CI, 0.49 to 0.67]; p < 0.001), and pain interference duration (chi-square = 43.47; p < 0.001) were associated with greater health-care utilization. Conclusions: Greater presurgical days’ supply of opioids and pain catastrophizing accounted for greater postsurgical days’ supply of opioids and health-care utilization. Consideration of several modifiable factors provides an opportunity to improve postsurgical outcomes. Level of Evidence: Prognostic Level III. 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引用次数: 3

摘要

背景:大多数接受选择性手术的个体期望在手术后停止使用阿片类药物,但许多人没有。包括社会心理因素在内的可改变的危险因素与术后不良预后相关。我们想知道疼痛灾难化是否与术后阿片类药物和医疗保健使用特别相关。方法:这是一项纵向队列研究,研究对象是2015年至2018年间接受选择性脊柱(腰椎或颈椎)或下肢(髋关节或膝关节骨关节炎)手术的试验参与者。主要和次要结局分别是术后12个月阿片类药物的供应和手术相关保健的利用。自我报告和医疗记录数据包括手术前疼痛灾难量表(PCS)评分、手术成功预期、阿片类药物使用和疼痛干扰持续时间。结果:对240名中位年龄为42岁的参与者(34%为女性,56%为现役军人)的完整结果进行了分析。在多变量广义加性模型中,手术前阿片类药物供应天数更大(F = 17.23, p < 0.001),疼痛灾难化程度更高(F = 1.89, p = 0.004),脊柱手术与下肢手术(系数估计= 1.66[95%置信区间(CI), 0.50至2.82];p = 0.005),女性相对于男性(系数估计= - 1.25 [95% CI, - 2.38至- 0.12];P = 0.03)与术后12个月阿片类药物供应增加相关。手术前阿片类药物日供应量(卡方= 111.95;P < 0.001),疼痛灾难化(卡方= 96.06;p < 0.001),下肢手术(系数估计= - 0.17 [95% CI, - 0.24至- 0.11];P < 0.001),除年龄外(卡方= 344.60;P < 0.001),术后预期恢复(卡方= 54.44;p < 0.001)、现役状态(系数估计= 0.58 [95% CI, 0.49 ~ 0.67];P < 0.001),疼痛干扰持续时间(χ 2 = 43.47;P < 0.001)与较高的医疗保健利用率相关。结论:更多的术前阿片类药物供应和疼痛灾变是术后阿片类药物供应和医疗保健利用增加的原因。考虑几个可改变的因素提供了改善术后预后的机会。证据等级:预后III级。有关证据水平的完整描述,请参见作者说明。
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Pain Catastrophizing Predicts Opioid and Health-Care Utilization After Orthopaedic Surgery
Background: Most individuals undergoing elective surgery expect to discontinue opioid use after surgery, but many do not. Modifiable risk factors including psychosocial factors are associated with poor postsurgical outcomes. We wanted to know whether pain catastrophizing is specifically associated with postsurgical opioid and health-care use. Methods: This was a longitudinal cohort study of trial participants undergoing elective spine (lumbar or cervical) or lower-extremity (hip or knee osteoarthritis) surgery between 2015 and 2018. Primary and secondary outcomes were 12-month postsurgical days’ supply of opioids and surgery-related health-care utilization, respectively. Self-reported and medical record data included presurgical Pain Catastrophizing Scale (PCS) scores, surgical success expectations, opioid use, and pain interference duration. Results: Complete outcomes were analyzed for 240 participants with a median age of 42 years (34% were female, and 56% were active-duty military service members). In the multivariable generalized additive model, greater presurgical days’ supply of opioids (F = 17.23, p < 0.001), higher pain catastrophizing (F = 1.89, p = 0.004), spine versus lower-extremity surgery (coefficient estimate = 1.66 [95% confidence interval (CI), 0.50 to 2.82]; p = 0.005), and female relative to male sex (coefficient estimate = −1.25 [95% CI, −2.38 to −0.12]; p = 0.03) were associated with greater 12-month postsurgical days’ supply of opioids. Presurgical opioid days’ supply (chi-square = 111.95; p < 0.001), pain catastrophizing (chi-square = 96.06; p < 0.001), and lower extremity surgery (coefficient estimate = −0.17 [95% CI, −0.24 to −0.11]; p < 0.001), in addition to age (chi-square = 344.60; p < 0.001), expected recovery after surgery (chi-square = 54.44; p < 0.001), active-duty status (coefficient estimate = 0.58 [95% CI, 0.49 to 0.67]; p < 0.001), and pain interference duration (chi-square = 43.47; p < 0.001) were associated with greater health-care utilization. Conclusions: Greater presurgical days’ supply of opioids and pain catastrophizing accounted for greater postsurgical days’ supply of opioids and health-care utilization. Consideration of several modifiable factors provides an opportunity to improve postsurgical outcomes. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
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