芯片上器官技术综述

Suresh A. Marnoor
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引用次数: 0

摘要

器官芯片(OOAC),也被称为微生理系统或“组织芯片”(名称可互换),近年来因其在药物开发过程的不同阶段提供信息的能力而获得了很多关注。这项尖端技术可以帮助研究人员更好地了解正常的人体器官功能和疾病病理,以及预测实验药物在人体中的安全性和有效性。因此,在不久的将来,它们有望成为标准的临床前细胞培养方法和体内动物研究的有益补充,从长远来看,甚至可能成为替代品。本文概述了这种快速发展的技术。
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A Short Review on Organ-on-a-chip Technology
Organ-on-a-chip (OOAC), also known as microphysiological systems or 'tissue chips' (the names are interchangeable), have gained a lot of attention in recent years because of their ability to provide information at different phases of the drug development process. This cutting-edge technology could help researchers better understand normal human organ function and disease pathology, as well as forecast the safety and efficacy of experimental medications in humans. As a result, they are expected to be beneficial supplements to standard preclinical cell culture methods and in vivo animal research in the near future, and possibly even replacements in the long run. This article presents an overview of this rapidly expanding technology.
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