用于TOF-PET达到100ps符合时间分辨率的闪烁探测器的光学反射器的研究

A. Gonzalez-Montoro, S. Pourashraf, M. S. Lee, J. Cates, Zhixiang Zhao, C. Levin
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摘要

在PET中加入511 keV光子飞行时间(TOF)信息可以显著提高重建图像的信噪比(SNR)。这种信噪比提升取决于PET系统的511 keV光子对符合时间分辨率(CTR),这是由几个因素决定的,包括闪烁晶体和光电探测器的特性、晶体-传感器耦合配置和反射材料。目前工作的目标是实现100皮秒(ps)的CTR,与目前具有250-400 ps CTR的最先进的PET系统相比,重建图像的信噪比提高了2倍以上。实现这一目标的关键参数是光学反射器对光收集和光到光电探测器的传输时间的影响。对于实验装置,我们使用了基于3×3×10和3×3×20 mm3 LGSO晶体的PET探测器元件,通过使用新颖的“侧读出”配置将其耦合到sipm阵列。我们通过在晶体表面应用四种不同的反射材料来测试CTR的性能,即增强镜面反射材料(ESR)、特氟龙、BaSO4涂料和TiO2涂料。此外,我们还通过测试3×3×10mm3和3×3×20mm3 LGSO晶体来评估闪烁晶体长度对CTR性能的影响。
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Study of optical reflectors used in scintillation detectors that achieve 100 ps coincidence time resolution for TOF-PET
Incorporating 511 keV photon time-of-flight (TOF) information in PET enables a significant boost in reconstructed image signal-to-noise ratio (SNR). This SNR boost depends on the 511 keV photon pair coincidence time resolution (CTR) of the PET system, which is determined by several factors including properties of the scintillation crystal and photodetector, crystal-to-sensor coupling configurations, and reflective materials. The goal of the present work is to achieve 100 picoseconds (ps) CTR for > 2-fold additional improvement in reconstructed image SNR compared to state-of-the-art PET systems that currently have 250–400 ps CTR. A critical parameter to optimize in achieving this goal is the optical reflector's influence on light collection and transit time to the photodetector. For the experimental set-up, we made use of PET detector elements based on both 3×3×10 and 3×3×20 mm3 LGSO crystals coupled to an array of SiPMs by using a novel “side-readout” configuration. We have tested the CTR performance by applying four different reflector materials to the crystal surfaces namely: Enhanced Specular Reflector (ESR), Teflon, BaSO4 paint and TiO2 paint. In addition, we have also evaluated the influence of the scintillation crystal length on the CTR performance by testing 3×3×10mm3 and 3×3×20mm3 LGSO crystals.
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