苯并三唑的药用前景及生物学行为研究综述其多方面生物活性的综合研究

V. Anjana, P. M. Kumar
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摘要

苯并三唑(BTA)是一种含氮杂环衍生物,其化学式为C6H5N3,在1、2、3位上含有3个氮原子。苯并三唑及其衍生物在药物化学中具有重要意义,由于其具有广泛的药理活性,包括抗菌、抗真菌、抗病毒、抗炎、抗高血糖、抗高血压、抗癌和镇痛活性,因此被许多化学家用于治疗条件。本文综述了苯并三唑的不同合成方法,苯并三唑衍生物在生物医学研究中的重要性,重点介绍了其生物学行为、多用途活性和构效关系(SAR)的研究。本文的综述将有助于研究人员了解其结构与活性之间的关系,并对其研究领域的概念进行改进。
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An Overview on Medicinal Perspective and Biological Behavior of Benzotriazole; Synthetic Study on Its Multifaceted Biological Activities
Benzotriazole (BTA) is a nitrogen containing heterocyclic derivative containing three nitrogen atoms at 1 st , 2 nd and 3 rd positions with chemical formula C6H5N3. Benzotriazole and its derivatives have great significance in medicinal chemistry and these derivatives were used by several chemists for therapeutic conditions because it possessing a wide spectrum of pharmacological activities including anti bacterial, anti fungal, anti viral, anti inflammatory, anti hyperglycemic, anti hypertensive, anti cancer and analgesic activity. In this review, different synthetic methods for the preparation of benzotriazole, importance of benzotriazole derivatives in biomedical research, highlighting its biological behavior, versatile activities and Structure Activity Relationship (SAR) studies are described. This review will help the researchers to understand the structure activity relationships and improvise the concepts in their research field.
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