利用机器学习的进步预测癌症治疗。

IF 2.5 4区 医学 Q3 ONCOLOGY Recent patents on anti-cancer drug discovery Pub Date : 2023-01-01 DOI:10.2174/1574892818666221018091415
Arun Kumar Singh, Jingjing Ling, Rishabha Malviya
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引用次数: 1

摘要

许多癌症患者死于治疗失败,因为他们的疾病对化疗和其他形式的放射治疗有抵抗力。耐药性可能在治疗的任何阶段产生,甚至在开始的时候。有几个因素影响目前的治疗,包括癌症的类型和遗传异常的存在。对治疗的反应并不总是由基因突变的存在来预测,并且可能因不同的癌症亚型而有所不同。很明显,癌症患者必须根据预测模型接受特定的治疗或药物组合。利用基于人工智能的预测模型进行的初步研究显示出了令人鼓舞的结果。由于缺乏足够的临床重要药物基因组学数据,尽管计算机容量大大增加,但建立治疗上有用的模型仍然很困难。机器学习是人工智能中应用最广泛的分支。在这里,我们回顾了使用机器学习预测治疗反应领域的现状。此外,还提供了在临床实践中使用的机器学习算法的示例。
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Prediction of Cancer Treatment Using Advancements in Machine Learning.

Many cancer patients die due to their treatment failing because of their disease's resistance to chemotherapy and other forms of radiation therapy. Resistance may develop at any stage of therapy, even at the beginning. Several factors influence current therapy, including the type of cancer and the existence of genetic abnormalities. The response to treatment is not always predicted by the existence of a genetic mutation and might vary for various cancer subtypes. It is clear that cancer patients must be assigned a particular treatment or combination of drugs based on prediction models. Preliminary studies utilizing artificial intelligence-based prediction models have shown promising results. Building therapeutically useful models is still difficult despite enormous increases in computer capacity due to the lack of adequate clinically important pharmacogenomics data. Machine learning is the most widely used branch of artificial intelligence. Here, we review the current state in the area of using machine learning to predict treatment response. In addition, examples of machine learning algorithms being employed in clinical practice are offered.

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来源期刊
CiteScore
4.50
自引率
7.10%
发文量
55
审稿时长
3 months
期刊介绍: Aims & Scope Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-cancer drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-cancer drug discovery.
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