慢性肾病患者亚临床和临床甲状腺功能减退症发生率的横断面研究

PJ Kowsika Shree, H. Kumari, H. Nalinisofia, T. Lakshmikantham, R. Kumari
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摘要

背景:甲状腺激素在肾脏发育和生理中起着重要作用。研究表明,慢性肾脏疾病(CKD)中,随着肾小球滤过率(Glomerular Filtration Rate, GFR)的下降,发生临床和亚临床甲状腺功能减退(hypothyroidism, SCH)的可能性更高。随着GFR的下降,甲状腺在结构和功能水平上出现了一些异常。目的:通过实验室调查(甲状腺功能检查)了解慢性肾病患者亚临床和临床甲状腺功能减退的发生率。材料和方法:这是一项横断面研究,采用非随机抽样方法,在Siddha国家研究所报告的50例CKD患者中进行。在获得知情同意后,收集每位患者的血液样本以记录其甲状腺状况。结果:根据所报告的甲状腺资料,亚临床甲状腺功能减退19例,临床甲状腺功能减退6例。结论:50例慢性肾病患者就诊于Ayothidoss Pandithar医院、National Institute of Siddha、Tambaram疗养院门诊,亚临床和临床甲状腺功能减退的发生率分别为38%(19例)和12%(6例)。
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A CROSS-SECTIONAL STUDY ON THE FREQUENCY OF KURAIVEETHANA NOI (SUBCLINICAL AND CLINICAL HYPOTHYROIDISM) AMONG CHRONIC KIDNEY DISEASE PATIENTS
Background: Thyroid hormones have a major role in renal development and physiology. It has been shown that in chronic kidney disease (CKD), as the Glomerular Filtration Rate (GFR) falls, there is a higher possibility of developing clinical and subclinical hypothyroidism (SCH). With falling GFR, several abnormalities are growing in the thyroid gland at both structural and functional levels. Objective: To estimate the frequency of kuraiveethana noi (subclinical and clinical hypothyroidism) among CKD patients through lab investigation (Thyroid Function Test). Materials and Methods: It is a cross-sectional study carried out on 50 CKD patients reporting at the National Institute of Siddha using a non-random sampling method. After obtaining informed consent, Blood samples were collected from each patient to document their Thyroid profile. Results: Based on their report of thyroid profile, 19 patients had subclinical hypothyroidism, and 6 patients had clinical hypothyroidism. Conclusion: The study concludes that the frequency of subclinical and clinical hypothyroidism is found to be 38% (19 patients) and 12% (6 patients), respectively, among 50 chronic kidney disease patients who visited OPD of Ayothidoss Pandithar Hospital, National Institute of Siddha, Tambaram sanatorium.
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