金丝雀相关肽和阿司匹林对注意力缺陷多动障碍患者代谢参数和进食行为的潜在影响

IF 1 4区医学 Q4 CLINICAL NEUROLOGY Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2024-02-24 eCollection Date: 2024-01-01 DOI:10.29399/npa.28458

Nilifer Gürbüzer, Sertaç Zengil, Esra Laloğlu, Kamber Kaşali

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引用次数: 0

摘要

简介我们的目的是评估注意力缺陷多动障碍（ADHD）成人患者体内的农杆菌相关肽（Agouti-Related Peptide，AgRP）和阿斯巴嗪（asprosin）水平，并研究进食行为、代谢参数、AgRP和阿斯巴嗪之间的关系：研究纳入了 45 名成人注意力缺陷多动障碍患者和 45 名对照者。对参与者进行了成人多动症诊断访谈量表（DIVA 2.0）和《精神疾病诊断与统计手册-5临床医师版》结构化临床访谈（SCID-5/CV）。参与者填写了成人注意缺陷多动障碍自评量表（ASRS）和荷兰饮食行为问卷（DEBQ）。对参与者的生化指标、AgRP和天冬氨酸水平进行了测量：结果：患有多动症的成年人的 HbA1c、体重指数（BMI）和腰围明显更高。患者的进食行为和血脂状况均受到影响。患者的 ASRS/多动-冲动评分与 DEBQ/情绪化进食和 DEBQ/外食之间存在明显的正相关。ASRS/总分与DEBQ/情绪化进食、DEBQ/外源性进食和DEBQ/总进食得分之间存在明显的正相关。患者的 AgRP 和 Asprosin 水平明显较低。AgRP和asprosin的效应大小分别为0.526和0.839。研究发现，患者的 AgRP 和asprosin 水平与体重指数呈负相关。由此可见，AgRP和asprosin是相互混杂的因素，而组间的显著性是由asprosin造成的。与 AgRP 相比，Asprosin 对多动症的定义率更高：该研究强调了多动症患者饮食行为与享乐系统之间的联系。研究还表明，成人多动症患者的 AgRP 和 Asprosin 水平较低。AgRP和asprosin水平低可能是能量平衡受损和/或导致ADHD的结构性原因。

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The Potential Impact of Agouti Related Peptide and Asprosin on Metabolic Parameters and Eating Behavior in Attention Deficit Hyperactivity Disorder.

Introduction: We aimed to evaluate Agouti-Related Peptide (AgRP) and asprosin levels in adults with Attention Deficit Hyperactivity Disorder (ADHD), and to examine the relationship between eating behavior, metabolic parameters, AgRP and asprosin.

Methods: Forty-five adult ADHD patients and 45 controls were included in the study. The Adult Diagnostic Interview Scale for ADHD (DIVA 2.0) and Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-5 Clinician Version (SCID-5/CV) were administered to the participants. The Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS) and the Dutch Eating Behavior Questionnaire (DEBQ) were completed by the participants. Biochemical parameters, AgRP and asprosin levels of the participants were measured.

Results: Adults with ADHD had significantly higher HbA1c, body mass index (BMI), and waist circumference. Eating behaviors and lipid profile were impaired in the patients. A significant positive correlation was found between the patients' ASRS/hyperactivity-impulsivity scores and DEBQ/emotional eating and DEBQ/external eating. A significant positive correlation was found between ASRS/total score and DEBQ/emotional eating, DEBQ/external eating, and DEBQ/total eating scores. AgRP and asprosin levels were significantly lower in the patients. The effect sizes of AgRP and asprosin were 0.526 and 0.839, respectively. A negative correlation was found between AgRP and asprosin levels of the patients and BMI. It was seen that AgRP and asprosin were confounding factors for each other, and the significance between the groups was due to asprosin. Asprosin defined ADHD at a higher rate than AgRP.

Conclusion: The study emphasizes the link between eating behavior and the hedonic system in ADHD. It also showed that AgRP and asprosin levels are low in adult ADHD. Low AgRP and asprosin levels may be an indication of impaired energy homeostasis and/or a structural cause for ADHD.

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来源期刊

Noropsikiyatri Arsivi-Archives of Neuropsychiatry CLINICAL NEUROLOGY-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume. Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.