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The Potential Impact of Agouti Related Peptide and Asprosin on Metabolic Parameters and Eating Behavior in Attention Deficit Hyperactivity Disorder. 金丝雀相关肽和阿司匹林对注意力缺陷多动障碍患者代谢参数和进食行为的潜在影响
IF 1.1 Pub Date : 2024-02-24 eCollection Date: 2024-01-01 DOI: 10.29399/npa.28458
Nilifer Gürbüzer, Sertaç Zengil, Esra Laloğlu, Kamber Kaşali

Introduction: We aimed to evaluate Agouti-Related Peptide (AgRP) and asprosin levels in adults with Attention Deficit Hyperactivity Disorder (ADHD), and to examine the relationship between eating behavior, metabolic parameters, AgRP and asprosin.

Methods: Forty-five adult ADHD patients and 45 controls were included in the study. The Adult Diagnostic Interview Scale for ADHD (DIVA 2.0) and Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-5 Clinician Version (SCID-5/CV) were administered to the participants. The Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS) and the Dutch Eating Behavior Questionnaire (DEBQ) were completed by the participants. Biochemical parameters, AgRP and asprosin levels of the participants were measured.

Results: Adults with ADHD had significantly higher HbA1c, body mass index (BMI), and waist circumference. Eating behaviors and lipid profile were impaired in the patients. A significant positive correlation was found between the patients' ASRS/hyperactivity-impulsivity scores and DEBQ/emotional eating and DEBQ/external eating. A significant positive correlation was found between ASRS/total score and DEBQ/emotional eating, DEBQ/external eating, and DEBQ/total eating scores. AgRP and asprosin levels were significantly lower in the patients. The effect sizes of AgRP and asprosin were 0.526 and 0.839, respectively. A negative correlation was found between AgRP and asprosin levels of the patients and BMI. It was seen that AgRP and asprosin were confounding factors for each other, and the significance between the groups was due to asprosin. Asprosin defined ADHD at a higher rate than AgRP.

Conclusion: The study emphasizes the link between eating behavior and the hedonic system in ADHD. It also showed that AgRP and asprosin levels are low in adult ADHD. Low AgRP and asprosin levels may be an indication of impaired energy homeostasis and/or a structural cause for ADHD.

简介我们的目的是评估注意力缺陷多动障碍(ADHD)成人患者体内的农杆菌相关肽(Agouti-Related Peptide,AgRP)和阿斯巴嗪(asprosin)水平,并研究进食行为、代谢参数、AgRP和阿斯巴嗪之间的关系:研究纳入了 45 名成人注意力缺陷多动障碍患者和 45 名对照者。对参与者进行了成人多动症诊断访谈量表(DIVA 2.0)和《精神疾病诊断与统计手册-5临床医师版》结构化临床访谈(SCID-5/CV)。参与者填写了成人注意缺陷多动障碍自评量表(ASRS)和荷兰饮食行为问卷(DEBQ)。对参与者的生化指标、AgRP和天冬氨酸水平进行了测量:结果:患有多动症的成年人的 HbA1c、体重指数(BMI)和腰围明显更高。患者的进食行为和血脂状况均受到影响。患者的 ASRS/多动-冲动评分与 DEBQ/情绪化进食和 DEBQ/外食之间存在明显的正相关。ASRS/总分与DEBQ/情绪化进食、DEBQ/外源性进食和DEBQ/总进食得分之间存在明显的正相关。患者的 AgRP 和 Asprosin 水平明显较低。AgRP和asprosin的效应大小分别为0.526和0.839。研究发现,患者的 AgRP 和asprosin 水平与体重指数呈负相关。由此可见,AgRP和asprosin是相互混杂的因素,而组间的显著性是由asprosin造成的。与 AgRP 相比,Asprosin 对多动症的定义率更高:该研究强调了多动症患者饮食行为与享乐系统之间的联系。研究还表明,成人多动症患者的 AgRP 和 Asprosin 水平较低。AgRP和asprosin水平低可能是能量平衡受损和/或导致ADHD的结构性原因。
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引用次数: 0
PEMODELAN REGRESI NONPARAMETRIK SPLINE TRUNCATED KASUS KEJADIAN DIARE DI PROVINSI BALI 巴厘岛非参数花键截断回归模型
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p438
Nadiya Yuvita Rizki, Gusti Ayu Made Srinadi, I. Komang, Gde Sukarsa
Nonparametric regression is a flexible approach used to determine the relationship between the predictor variable and the response variable is unknown. One method that can be used to estimate nonparametric regression models is the truncated spline. The truncated spline is an effective method to estimate nonparametric regression models due to its ability to adapt to the data's characteristics through knots. Truncated spline estimates its parameters with the maximum likelihood estimator (MLE) method and finds the optimal knot points with the minimum generalized cross validation (GCV) value. This study used the truncated spline to model diarrhea cases in Bali Province, examining five variables that could affect incidence. The optimal knot points were 2-1-3-3-2 with a minimum GCV value of  67572,38. The study found that the number of clean drinking water facilities, food management places that meet health requirements, public places that meet health requirements, population density, and access to proper sanitation facilities had a significant effect on diarrhea incidence. The coefficient of determination for this model is 98,87%.
非参数回归是一种灵活的方法,用于确定预测变量与未知响应变量之间的关系。截断样条曲线是用于估计非参数回归模型的一种方法。截尾样条线是估计非参数回归模型的一种有效方法,因为它能够通过结点来适应数据的特征。截断样条线使用最大似然估计法(MLE)估计参数,并以最小广义交叉验证(GCV)值找到最佳结点。本研究使用截断样条曲线对巴厘省的腹泻病例进行建模,研究了可能影响发病率的五个变量。最佳结点为 2-1-3-3-2,最小 GCV 值为 67572,38。研究发现,清洁饮用水设施的数量、符合卫生要求的食品经营场所、符合卫生要求的公共场所、人口密度和获得适当卫生设施的机会对腹泻发病率有显著影响。该模型的决定系数为 98.87%。
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引用次数: 0
PERAMALAN VOLATILITAS RETURN NILAI TUKAR RUPIAH TERHADAP US DOLLAR MENGGUNAKAN METODE EGARCH, TGARCH, DAN APARCH 使用 EGARCH、TGARCH 和 APARCH 方法预测印尼盾兑美元汇率的波动性
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p445
Made Nonik, Pramesti Karana, Wayan Sumarjaya, Kartika Sari
Exchange rates play a crucial role among macroeconomic variables, exerting a significant influence on a country's economic landscape. Fluctuations in these rates can impact a nation's stability and economic activities. Consequently, it becomes essential to engage in forecasting endeavors, particularly in predicting the exchange rate of the rupiah against foreign currencies, with a focus on the US dollar. Certain instances in financial data reveal an asymmetric volatility response, often referred to as the leverage effect. To address this challenge, asymmetric GARCH models, including EGARCH, TGARCH, and APARCH, prove instrumental. This research endeavors to identify the most effective model among EGARCH, TGARCH, and APARCH using data pertaining to the rupiah's exchange rate against the US Dollar from March 2, 2020, to June 2, 2022. The findings indicate that the APARCH (1,2) model stands out as the optimal choice for predicting volatility, boasting the smallest AIC value in comparison to its counterparts. As per the research outcomes, volatility witnessed a decline from the initial day to the fourteenth day.
汇率在宏观经济变量中发挥着至关重要的作用,对一个国家的经济格局产生着重大影响。这些汇率的波动会影响一个国家的稳定和经济活动。因此,进行预测,尤其是预测印尼盾对外币(重点是美元)的汇率就变得至关重要。金融数据中的某些实例揭示了非对称波动反应,通常被称为杠杆效应。为了应对这一挑战,非对称 GARCH 模型(包括 EGARCH、TGARCH 和 APARCH)被证明是非常有用的。本研究利用 2020 年 3 月 2 日至 2022 年 6 月 2 日印尼盾兑美元汇率的相关数据,努力在 EGARCH、TGARCH 和 APARCH 中找出最有效的模型。研究结果表明,APARCH (1,2) 模型是预测波动性的最佳选择,与同类模型相比,其 AIC 值最小。根据研究结果,波动率从第一天到第十四天呈下降趋势。
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引用次数: 0
PENGELOMPOKKAN KABUPATEN DI PROVINSI JAWA TENGAH BERDASARKAN KARAKTERISTIK IKLIM MENGGUNAKAN FUZZY CLUSTERING 利用模糊聚类法根据气候特征对中爪哇省各地区进行聚类
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p442
Natalie Novenrodumetasa, G. K. Gandhiadi, Ketut Jayanegara, Kabupaten Purbalingga, Kabupaten Banjarnegara, Kabupaten Kebumen, Kabupaten Purworejo, Kabupaten Wonosobo, Kabupaten Magelang, Kabupaten Sukoharjo, Kabupaten Demak, K. Semarang, Kabupaten Pekalongan, Kota Magelang, Kabupaten Boyolali, Kabupaten Klaten, Kabupaten Wonogiri, Kabupaten Karanganyar, Kabupaten Sragen, Kabupaten Grobogan, Kabupaten Blora, Kabupaten Rembang, Kabupaten Pati, Kabupaten Kudus, Kabupaten Jepara, Kabupaten Temanggung, Kabupaten Kendal, Kabupaten Batang, Kabupaten Pemalang, Kabupaten Tegal
There are many factors affecting human life, one of which is climate. Differences in climatic conditions in each region result in differences in the environment in society. The differences are referred to as potential natural resources, livelihoods, and social cultural conditions. The climate has an impact on culture in terms of how people dress, the shape of houses, and so on. The regency group in Central Java Province is based on similarities in climate characteristics using fuzzy clustering. The data used were taken from Central Java Provincial Statistical Office in 2022.The results of district grouping in Central Java Province are based on similarities in climate characteristics using fuzzy clustering with 4 different number of clusters and the validity tests of the Partition Coefficient and Classification Entropy indices. Based on the results of the index validity test, the optimal grouping results are 2 clusters with a Partition Coefficient value of 0.911233 and a Classification Entropy value of 0.07979. The 1st cluster consists of 13 districts with a cluster center at 27.9°C for air temperature, 2418mm for rainfall, and 804% for keelThe 2nd cluster and airbase consist of 22 cluster central districts at 26.6 °C for air temperature, 4087 mm for rainfall, and 81.3% for humidity.
影响人类生活的因素有很多,气候就是其中之一。各地区气候条件的差异导致了社会环境的差异。这些差异被称为潜在的自然资源、生计和社会文化条件。气候对文化的影响体现在人们的衣着打扮、房屋形状等方面。中爪哇省的行政区分组是基于气候特征的相似性,采用模糊聚类的方法进行的。中爪哇省的县级分组结果是基于气候特征的相似性,使用了 4 个不同数量的聚类以及分区系数和分类熵指数的有效性检验。根据指数有效性检验的结果,最佳分组结果为 2 个聚类,分区系数值为 0.911233,分类熵值为 0.07979。第 1 个聚类由 13 个地区组成,聚类中心的气温为 27.9°C,降雨量为 2418 毫米,龙骨湿度为 804%;第 2 个聚类和航空基地由 22 个聚类中心地区组成,气温为 26.6°C,降雨量为 4087 毫米,湿度为 81.3%。
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引用次数: 0
ANALISIS MARKOV CHAIN DALAM MEMPREDIKSI MARKET SHARE DAN EQUILIBRIUM PENGGUNA LAPTOP MAHASISWA AKTIF UNIVERSITAS UDAYANA 马尔可夫链分析在预测乌达亚纳大学在校生笔记本电脑用户的市场份额和平衡方面的应用
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p443
Putu Regina Putri Chandri, Kadek Ayu Alit Suparti, NI Made Wahyu Fresilia, Thio Novryana, Made Ayu Dwi Octavanny
The goal of this research is to assess the shift in laptop brands among currently enrolled students at Udayana University and predict the market share when the system reaches a stable state for each switch made by these students. The study employs the Markov Chain method, a component of Stochastic Processes. This method generates probabilistic information that aids in decision-making. In Markov Chain analysis, the equilibrium condition refers to a state in a specific period where the transition probability matrix stabilizes. Data on laptop brand switches were collected from users who have utilized more than one laptop brand. The study provides in-depth insights into the behavior of laptop users in the academic environment of Udayana University. The results of this research provide deep insights into the behavior of laptop users in the academic environment of Udayana University, laying the groundwork for a better understanding of market trends and user preferences.
本研究的目标是评估乌达亚纳大学在校学生对笔记本电脑品牌的转换,并预测当系统达到稳定状态时,这些学生的每次转换所带来的市场份额。研究采用了马尔可夫链方法,这是随机过程的一个组成部分。该方法可生成有助于决策的概率信息。在马尔可夫链分析中,平衡条件是指在特定时期内过渡概率矩阵趋于稳定的状态。有关笔记本电脑品牌转换的数据是从使用过不止一个笔记本电脑品牌的用户那里收集的。本研究深入洞察了乌达亚纳大学学术环境中笔记本电脑用户的行为。本研究成果深入揭示了乌达亚纳大学学术环境中笔记本电脑用户的行为,为更好地了解市场趋势和用户偏好奠定了基础。
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引用次数: 0
PENERAPAN MODEL INVENTORI PROBABILISTIK FUZZY MULTIOBJEKTIF PADA SISTEM PERSEDIAAN BUAH SALAK 多目标模糊概率库存模型在沙拉克水果库存系统中的应用
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p440
Novi Rustiana Dewi, Eka Susanti, Des Alwine Zayanti, Indrawati Indrawati, Oki Dwipurwani, Siti Natasya Munawaroh
Inventory control is very important in production and trading activities. The purpose of inventory control is to maintain product availability. In certain cases, the products provided must be ordered from distributors outside the city and require waiting time from the time the order is placed until the product is received. The Multiobjective Probabilistic Fuzzy Inventory model can be applied to inventory optimization problems with the uncertainty of the leadtime parameter. In this study, the model was applied to the problem of supply salak fruit at one of the distributors. The first objective function is to minimize holding costs and the second is to minimize deterioration costs. The inventory model is transformed into a single objective form using a weighted method. Based on the results, the order cycle time is 3 days with the optimal total inventory of 430.1086 kg. The holding cost and deterioration costs are IDR 2,075,866 and IDR 571,034, respectively. Changes in the weight value of the objective function result in changes in the total cost value. The greater the weight for the first objective function, the smaller the total cost.
库存控制在生产和贸易活动中非常重要。库存控制的目的是保持产品的可用性。在某些情况下,所提供的产品必须从城市以外的分销商处订购,从下单到收到产品需要等待一段时间。多目标概率模糊库存模型可应用于提前期参数不确定的库存优化问题。在本研究中,该模型被应用于一家分销商的沙拉水果供应问题。第一个目标函数是使持有成本最小化,第二个目标函数是使变质成本最小化。使用加权法将库存模型转化为单一目标形式。根据计算结果,订货周期为 3 天,最佳库存总量为 430.1086 公斤。持有成本和变质成本分别为 2,075,866 印尼盾和 571,034 印尼盾。目标函数权重值的变化导致总成本值的变化。第一个目标函数的权重越大,总成本就越小。
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引用次数: 0
OPTIMASI PENUGASAN MELALUI PENERAPAN HUNGARIAN METHOD DAN NEW ALTERNATE METHOD 应用匈牙利方法和新的替代方法优化任务分配
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p435
Novita Triani Hamma, NI Ketut Tari Tastrawati, Kartika Sari
One of the materials discussed in operations research is linear programming, which also discusses models of transportation. The assignment problem can be viewed as a special case of the transportation model. One method that is often used to solve assignment problems is the Hungarian method. Over time, there have also been more and more alternative methods to streamline processing time in solving assignment problems, one of which is the new alternate method.   The purpose of this  research is to form an optimal scheduling with minimum processing time.  The data used in this study is secondary data obtained from CV Bagus Classic. The data consists of the number of workers, type of work, and the time needed to complete the work by each worker. As a result of this research, it was found that the minimum assignment time was achieved when using the Hungarian method compared to using the new alternate method or before using both methods.
线性规划是运筹学讨论的材料之一,它也讨论运输模型。分配问题可以看作是运输模型的一个特例。解决分配问题常用的一种方法是匈牙利法。随着时间的推移,也有越来越多的替代方法来简化解决分配问题的处理时间,新的替代方法就是其中之一。 本研究的目的是形成一个处理时间最短的最优排程。 本研究使用的数据是从 CV Bagus Classic 获得的二手数据。这些数据包括工人数量、工作类型以及每个工人完成工作所需的时间。研究结果表明,使用匈牙利方法与使用新的替代方法或在使用这两种方法之前相比,分配时间最短。
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引用次数: 0
KAUSALITAS ANTARA ANXIETY, SOCIAL PHOBIA TERHADAP PEMAIN VIDEO GAME 消除电子游戏中的焦虑、社交恐惧症
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p437
Alexander Joseph Riadi, I. K. G. Sukarsa, NI Luh Putu Suciptawati, Eka N. Kencana, Made Susilawati, G. K. Gandhiadi
Life satisfaction is one of the most ambigious concept to take a hold on. One’s degree of life satisfaction can differ from other person even though they have a realtively similliar life. This research studies people who play video games regularly (gamers) from the age of eighteen to fifty six. As one of the common trait or stereotipically seen that gamers have difficulty in social aspect of their lifes. Using Structural Equation Modeling (SEM), the research will try to confirm the relationship between anxiety and social phobia toward life satisfaction. The final model shows that anxiety and social phobia shows a significant negative affect towards life satisfaction of gamers.
生活满意度是最难以把握的概念之一。一个人的生活满意度可能与另一个人不同,即使他们的生活非常相似。本研究对 18 至 56 岁经常玩电子游戏的人(游戏玩家)进行了调查。游戏玩家的一个共同特征或刻板印象是,他们在生活的社交方面有困难。本研究将使用结构方程模型(SEM)来确认焦虑和社交恐惧症与生活满意度之间的关系。最终模型显示,焦虑和社交恐惧症对游戏玩家的生活满意度有显著的负面影响。
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引用次数: 0
ANALISIS PERSEPSI MASYARAKAT LOMBOK YANG BERDAMPAK COVID-19 TERHADAP DUKUNGAN UNTUK PARIWISATA 分析受 COVID-19 影响的龙目岛居民对支持旅游业的看法
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p444
MOCH. Anjas Aprihartha, Jus Prasetya, Sefri Imanuel Fallo
Structural Equation Model (SEM) merupakan salah satu dari teknik analisis dalam ilmu statistika dengan gabungan dua teknik multivariat yaitu analisis faktor konfirmatori, analisis regresi, dan analisis jalur. Pada penelitian ini diterapkan analisis SEM untuk menganalisa faktor yang memengaruhi masyarakat Lombok yang berdampak Covid-19 terhadap dukungan untuk pariwisata. Data yang digunakan adalah data primer yang diperoleh dengan kuesioner kepada masyarakat Lombok pada tahun 2021. Pada studi kasus ini peneliti mengambil dua faktor yang dapat memengaruhi dukungan terhadap pariwisata (ST) yaitu resiko yang dirasakan (PR) dan solidaritas emosional (ES). Tujuan dari penelitian ini untuk mengetahui pengaruh variabel PR dan ES terhadap ST. Berdasarkan hasil analisis diperoleh solidaritas emosional (ES) berpengaruh signifikan pada dukungan terhadap pariwisata. Sementara itu, resiko yang dirasakan (PR) dan solidaritas emosional (ES) bersama-sama secara signifikan mampu menjelaskan pengaruhnya dukungan terhadap pariwisata (ST) sebesar 72,6% sedangkan 27,4% dijelaskan oleh variabel lain diluar model.
结构方程模型(SEM)是统计学中的一种分析技术,结合了两种多元技术,即确证因子分析、回归分析和路径分析。本研究采用 SEM 分析方法来分析影响 Covid-19 的龙目岛居民支持旅游业的因素。所使用的数据是 2021 年通过对龙目岛居民进行问卷调查获得的原始数据。在本案例研究中,研究人员选取了两个可能影响旅游业支持率(ST)的因素,即感知风险(PR)和情感团结(ES)。本研究的目的是确定 PR 和 ES 变量对 ST 的影响。根据分析结果,情感团结(ES)对旅游支持有显著影响。同时,感知风险(PR)和情感团结(ES)共同对旅游支持(ST)的影响有 72.6% 的显著解释作用,而 27.4% 的解释作用由模型外的其他变量产生。
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引用次数: 0
PENERAPAN GOAL PROGRAMMING PADA PERENCANAAN OPTIMISASI ASET, LIABILITAS, EKUITAS, PENDAPATAN DAN BEBAN (STUDI KASUS: BANK 9 JAMBI) 目标规划在资产、负债、权益、收入和支出优化规划中的应用(案例研究:詹比第 9 银行)
Pub Date : 2024-01-31 DOI: 10.24843/mtk.2024.v13.i01.p441
Yemima Pipiyanti Br Ginting, Syamsyida Rozi, Niken Rarasati
Bank 9 Jambi requires optimization planning to maintain financial balance. The optimization is relate to five objectives that are maximize assets, minimize liabilities, maximize equity, maximize income, and minimize expenses. Therefore, the aim of this research was to analyze the possibility of optimization in financial report in Bank 9 Jambi. Because there are 5 objectives which were considered in this research, so the model applied is goal programming. By the result of goal programming, it was confirmed that Bank 9 Jambi can meet five goals as desired. Besides, in this research, sensitivity analysis was performed to identify whether the result of goal programming will be changed or not, especially the sensitivity analysis of right side of inequality in the constraints of the model. And the result of sensitivity analysis is that the five goals will still be met as long as the limit of total asset for 1.5 years is in the interval of IDR 75,314,347 million to IDR 77,831,122 million, the limit of minimum total liability is IDR 66,719,681 million, the limit of equity target is in the interval IDR 11,111,441 million to Rp.11. 482,751 million, the limit of total income is in the interval IDR 0 to IDR 6,542,843 million and the limit of total expense is at least IDR 1,435,052 million.
占碑第 9 银行需要优化规划以保持财务平衡。优化与五个目标有关,即资产最大化、负债最小化、权益最大化、收入最大化和支出最小化。因此,本研究旨在分析占碑银行财务报告优化的可能性。由于本研究考虑了 5 个目标,因此采用了目标规划模型。目标规划的结果证实,占碑银行可以达到预期的五个目标。此外,本研究还进行了敏感性分析,以确定目标规划的结果是否会发生变化,尤其是对模型约束条件中右侧不等式的敏感性分析。敏感性分析的结果是,只要 1.5 年的总资产限额在 753.14347 亿印尼盾至 778.31122 亿印尼盾之间,最低总负债限额为 667.19681 亿印尼盾,权益目标限额在 111.11441 亿印尼盾至 11.482,751 百万印尼盾,总收入限额为 0 至 6,542,843 百万印尼盾,总支出限额至少为 1,435,052 百万印尼盾。
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引用次数: 0
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