晚期慢性肾病患者亚临床甲状腺功能减退:患病率及相关因素

IF 1.7 Q4 ENDOCRINOLOGY & METABOLISM Journal of Thyroid Research Pub Date : 2022-05-17 DOI:10.1155/2022/1077553
Javier Reque Santivañez, Beatriz García Peris, Nayara Panizo González, Alejandro Pérez Alba, L. D’Marco, Eladio J. Collado Boira
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Filiation data, comorbidities, and routine blood and urine test results were registered. Results A total of 299 patients were included. Of them, 184 (61.5%) were men. The mean age was 71 ± 13 years old. The mean glomerular filtration rate (CKD-EPI) was 22 ± 9 ml/min/1.73 m2. According to chronic kidney disease stages, global distribution of patients was as follows: Stage 3, 67 patients (22.4%); Stage 4, 155 patients (51.8%); and Stage 5, 77 patients (25.8%). We found subclinical hypothyroidism in 54 (18.1%) patients. According to chronic kidney disease stages, distribution of affected patients was as follows: Stage 3, 9 patients (13%); Stage 4, 25 patients (16.1%); and Stage 5, 20 patients (26%). Differences among stages were statistically significant. By univariate analysis, factors related with subclinical hypothyroidism were as follows: age RR 1.048 (95% CI 1.019–1.078; p=0.001), hypertension RR 2.705 (95% CI 1.026–7.130; p=0.04), glomerular filtration rate RR 0.962 (95% CI 0.929–0.996; p=0.03), and proteinuria higher than 1 gram/day RR 2.387 (95% CI 1.303–4.374; p=0.005). By multivariate analysis adjusted by age, hypertension, glomerular filtration rate, proteinuria, diabetes, and cardiovascular disease history, only age RR 1.016 (95% CI 1.009–1.028; p=0.04) and glomerular filtration rate RR 0.963 (95% CI 0.930–0.997; p=0.03) preserved their independent association with subclinical hypothyroidism. Conclusions Subclinical hypothyroidism prevalence in patients with chronic kidney disease is high and increases with renal disease severity. 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引用次数: 0

摘要

肾功能与甲状腺代谢密切相关。然而,关于慢性肾脏疾病患者亚临床甲状腺功能减退的患病率及其相关因素的证据很少。目的分析晚期慢性肾脏病患者亚临床甲状腺功能减退的患病率及其相关因素。材料和方法。非透析依赖的慢性肾脏疾病3至5期患者被纳入研究。其他入选标准为年龄在18岁以上和临床稳定性。排除诊断为甲状腺疾病的患者。亚临床甲状腺功能减退定义为促甲状腺激素(TSH) > 5.3 mU/L,游离甲状腺素4 (FT4)在0.54 ~ 1.24 ng/dl之间。记录了家族史、合并症和血尿常规检查结果。结果共纳入299例患者。其中男性184人(61.5%)。平均年龄71±13岁。平均肾小球滤过率(CKD-EPI)为22±9 ml/min/1.73 m2。根据慢性肾脏疾病的分期,全球患者分布如下:3期,67例(22.4%);4期,155例(51.8%);5期77例(25.8%)。我们发现54例(18.1%)患者有亚临床甲状腺功能减退。根据慢性肾病的分期,受影响的患者分布如下:第3期9例(13%);4期,25例(16.1%);5期20例(26%)。分期间差异有统计学意义。单因素分析,与亚临床甲状腺功能减退相关的因素如下:年龄RR 1.048 (95% CI 1.019-1.078;p=0.001),高血压RR 2.705 (95% CI 1.026-7.130;p=0.04),肾小球滤过率RR 0.962 (95% CI 0.929-0.996;p=0.03),蛋白尿高于1克/天的RR为2.387 (95% CI 1.303-4.374;p = 0.005)。经年龄、高血压、肾小球滤过率、蛋白尿、糖尿病和心血管病史校正的多因素分析,只有年龄的RR为1.016 (95% CI 1.009-1.028;p=0.04),肾小球滤过率RR 0.963 (95% CI 0.930-0.997;P =0.03)与亚临床甲状腺功能减退保持独立关联。结论慢性肾病患者亚临床甲状腺功能减退的患病率较高,且随肾病严重程度的增加而增加。与亚临床甲状腺功能减退症独立相关的因素是年龄和肾小球滤过率。
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Subclinical Hypothyroidism in Advanced Chronic Kidney Disease Patients: Prevalence and Associated Factors
Introduction Renal function and thyroid metabolism are tightly related. However, evidence about subclinical hypothyroidism prevalence in patients with chronic kidney disease and its related factors is scarce. Objectives Our aim is to analyze subclinical hypothyroidism prevalence and its related factors in patients with advanced chronic kidney disease. Materials and methods. Nondialysis-dependent patients with chronic kidney disease at stages 3 to 5 were included. Other inclusion criteria were age above 18 years and clinical stability. Patients with diagnosed thyroid illnesses were excluded. Subclinical hypothyroidism was defined as thyroid stimulating hormone (TSH) > 5.3 mU/L, with free thyroxine 4 (FT4) between 0.54 and 1.24 ng/dl. Filiation data, comorbidities, and routine blood and urine test results were registered. Results A total of 299 patients were included. Of them, 184 (61.5%) were men. The mean age was 71 ± 13 years old. The mean glomerular filtration rate (CKD-EPI) was 22 ± 9 ml/min/1.73 m2. According to chronic kidney disease stages, global distribution of patients was as follows: Stage 3, 67 patients (22.4%); Stage 4, 155 patients (51.8%); and Stage 5, 77 patients (25.8%). We found subclinical hypothyroidism in 54 (18.1%) patients. According to chronic kidney disease stages, distribution of affected patients was as follows: Stage 3, 9 patients (13%); Stage 4, 25 patients (16.1%); and Stage 5, 20 patients (26%). Differences among stages were statistically significant. By univariate analysis, factors related with subclinical hypothyroidism were as follows: age RR 1.048 (95% CI 1.019–1.078; p=0.001), hypertension RR 2.705 (95% CI 1.026–7.130; p=0.04), glomerular filtration rate RR 0.962 (95% CI 0.929–0.996; p=0.03), and proteinuria higher than 1 gram/day RR 2.387 (95% CI 1.303–4.374; p=0.005). By multivariate analysis adjusted by age, hypertension, glomerular filtration rate, proteinuria, diabetes, and cardiovascular disease history, only age RR 1.016 (95% CI 1.009–1.028; p=0.04) and glomerular filtration rate RR 0.963 (95% CI 0.930–0.997; p=0.03) preserved their independent association with subclinical hypothyroidism. Conclusions Subclinical hypothyroidism prevalence in patients with chronic kidney disease is high and increases with renal disease severity. Factors independently related to subclinical hypothyroidism are age and glomerular filtration rate.
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来源期刊
Journal of Thyroid Research
Journal of Thyroid Research ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
10
审稿时长
17 weeks
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