绿色化学:以罗谢尔盐为新型绿色催化剂的三组份反应新合成取代铬和苯并铬

A. El-Maghraby
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引用次数: 18

摘要

以芳香醛(1)、丙二腈(2)、间苯二酚(3)或α-萘酚(4)或β-萘酚(5)为催化剂,以Rochelle盐作为新型绿色非均相可重复使用的催化剂,在乙醇或水回流条件下,通过一锅三组分反应,以较好的收率制备了取代的2-氨基-4-芳基-4-羟基-4-铬-3-碳腈(6)、2-氨基-4-芳基-4-苯并[h]铬-3-碳腈(7)和3-氨基-1-芳基-1-苯并[f]铬-2-碳腈(8)。
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Green Chemistry: New Synthesis of Substituted Chromenes and Benzochromenes via Three-Component Reaction Utilizing Rochelle Salt as Novel Green Catalyst
Substituted 2-amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles (6), 2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles (7), and 3-amino-1-aryl-1H-benzo[f]chromenes-2-carbonitriles (8) were prepared, in good yields, via one-pot three-component reactions of aromatic aldehydes (1), malononitrile (2), and resorcinol (3) or α-naphthol (4) or β-naphthol (5) in refluxing ethanol or water in the presence of Rochelle salt as novel green heterogeneous and reusable catalyst.
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