70例冠状病毒病伴腹泻患者临床特征分析

中华消化杂志 Pub Date : 2020-03-30 DOI:10.3760/CMA.J.CN311367-20200315-00141

Yuanmei Guo, Jixiang Zhang, Qiutang Xiong, Jiao Li, Mengyao Ji, P. An, Xiaoguang Lyu, Fei Liao, Wenhao Su, W. Dong

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引用次数: 1

摘要

目的回顾性分析2019冠状病毒病(COVID-19)合并腹泻患者的临床特点。方法收集2020年1月11日至2月6日武汉大学人民医院收治的663例新冠肺炎确诊患者的临床资料。根据有无腹泻分为有腹泻组和无腹泻组。比较两组患者一般情况、临床表现、胸部CT、实验室检查、病情严重程度及死亡情况的差异。采用卡方检验、Fisher精确检验和Mann-Whitney U检验进行统计学分析。结果663例新冠肺炎患者中有70例(10.6%)伴有腹泻。腹泻组的疲劳率和乳酸脱氢酶(LDH)升高率高于未腹泻组(58.6%，41/70比28.2%，167/593;64.2%(43/67比50.4%，277/550)，差异有统计学意义(χ2=26.891、4.566,P均为0.05)。轻度型与正常型、重度型与危重型的比例，腹泻组与无腹泻组比较差异无统计学意义(35.7%，25/70比38.6%，229/593;50.0%， 35/70 vs. 47.2%， 280/593;14.3%， 10/70比14.2%，84/593)(χ2=0.240, P=0.887)。腹泻组与无腹泻组各对应轻、正常型、重度、危重型的死亡率比较，差异均无统计学意义(0比0.5%，3/593;0比0和1.4%，1/70比3.5%，21/593)(Fisher精确检验，P均>0.05)。结论COVID-19合并腹泻患者更容易出现疲劳和LDH升高。腹泻与COVID-19患者病情严重程度无显著相关性。关键词:COVID-19;腹泻;临床特点;疾病严重程度

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Clinical characteristics of 70 patients with coronavirus disease 2019 accompanied with diarrhea

Objective To retrospectively analyze the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) accompanied with diarrhea. Methods From January 11 to February 6 in 2020, the clinical data of 663 patients diagnosed with COVID-19 admitted to Renmin Hospital of Wuhan University were collected. According to whether with diarrhea, the patients were divided into with diarrhea group and without diarrhea group. The differences in general condition, clinical manifestation, chest computed tomography (CT), laboratory findings, disease severity and death situation between two groups were compared. Chi-square test, Fisher exact test and Mann-Whitney U test were performed for statistical analysis. Results Among 663 COVID-19 patients, 70 (10.6%) patients accompanied with diarrhea. The ratio of fatigue and increased lactate dehydrogenase (LDH) of with diarrhea group were higher than those of without diarrhea group (58.6%, 41/70 vs. 28.2%, 167/593; and 64.2%, 43/67 vs. 50.4%, 277/550), and the differences were statistically significant (χ2=26.891 and 4.566, both P 0.05). There were no statistically significant differences in the ratio of mild and normal type, severe type and critical type between diarrhea group and without diarrhea group (35.7%, 25/70 vs. 38.6%, 229/593; 50.0%, 35/70 vs. 47.2%, 280/593; and 14.3%, 10/70 vs. 14.2%, 84/593, respectively) (χ2=0.240, P=0.887). There were no statistically significant differences in the ratio of death of each corresponding mild and normal type, severe type and critical type between diarrhea group and without diarrhea group (0 vs. 0.5%, 3/593; 0 vs 0 and 1.4%, 1/70 vs. 3.5%, 21/593) (Fisher exact test, all P>0.05). Conclusions Patients with COVID-19 accompanied with diarrhea are more likely to have fatigue and increased LDH. Diarrhea is not significantly correlated with the disease severity of patients with COVID-19. Key words: COVID-19; Diarrhea; Clinical characteristics; Disease severity

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