冷冻干燥阿拉比卡咖啡皮(Coffea arabica)作为口服抗菌剂的好处

Agus Sumono, T. Indriana, Y. M. Utami, Disaera
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摘要

背景:目前治疗口腔感染使用的是合成药物,即可引起耐药细菌的抗菌素(抗生素和抗真菌药),因此需要草药类的替代抗菌素。阿拉比卡咖啡皮含有植物化学化合物(多酚、生物碱、皂苷),具有天然抗菌的潜力。目的:研究阿拉比卡咖啡皮废弃物对变形链球菌、牙龈卟啉单胞菌和白色念珠菌生长的抑制作用。方法:本实验室采用后测组设计,分别用25%、50%和75%的冷冻干咖啡皮制作;阳性对照用氯己定和制霉菌素。抗菌试验方法采用扩散法,菌落计数法计算菌落生长。结果:不同浓度的溶液对三种微生物的抑菌作用均增强。这表明,浓度与微生物菌落数量之间存在很强的正相关关系。干阿拉比卡咖啡皮浓度越高,杀菌效果越好。效果最大的依次是白色念珠菌、牙龈假单胞菌、变形链球菌。结论:阿拉比卡咖啡果皮可作为抗变形链球菌、牙龈假单胞菌和白色假单胞菌生长的抗菌口腔。
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Benefits of freeze dried arabica coffee peels (Coffea arabica) as an oral antimicrobial
Background: Oral infections are currently treated with synthetic drugs, namely antimicrobials (antibiotics and antifungals) that can cause resistant bacteria, so alternative antimicrobials from herbal groups are needed. Arabica coffee peel contains phytoche-mical compounds (polyphenols, alkaloids, saponins) which have potential as natural antibacterial. Purpose:To examine the benefits of waste of arabica coffee rind in inhibiting growth of Streptococcus mutans, Porphyromonas gingivalis and Candida albicans. Methods: This experimental laboratory with the post test only group design was started with making of freeze dried coffee peels 25%, 50% and 75%; positive control used chlorhexidine and nystatin. The antimicrobial test method was performed by the diffusion method and the growth of microbial colonies was calculated using a colony counter. Result: Antimicrobial effect increased at all concentration of test solutions to the three microbes. This shows that there is a strong positive relationship between concentration and the number of microbial colonies. The higher concentration of dried arabica coffee peels, the greater the effect of microbial killing power. The biggest effect is on C.albicans, P.gingivalis, S.mutans, consecutively. Conclusion: arabica coffee fruit skin can be used as an antimicrobial oral cavity against the growth of S.mutans, P.gingivalis and C.albicans.
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