3-取代愈创唑烯衍生物的合成及抗氧化活性研究

Natural Product Letters Pub Date : 2002-01-01 DOI:10.1080/10575630290013585

H. Pratsinis, S. Haroutounian

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引用次数: 10

摘要

合成了一系列3-取代的愈创唑烯衍生物，并通过监测其清除稳定自由基DPPH的能力来评价其抗氧化性能。3-乙烯基愈创蓝烯的抗氧化活性最强，其抗氧化活性优于f -生育酚。这些衍生物也是人类早幼粒细胞白血病细胞增殖的中度抑制剂。

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Synthesis and Antioxidant Activity of 3-Substituted Guaiazulene Derivatives

A series of 3-substituted guaiazulene derivatives has been synthesized and their antioxidant properties were evaluated by monitoring their capacity for scavenging the stable free-radical DPPH. 3-Vinylguaiazulene was the most potent, possessing antioxidant activity superior than f -tocopherol. These derivatives were also moderate inhibitors of the proliferation of human promyelocytic leukemia cells.

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Natural Product Letters

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