姜黄素纳米制剂用于癌症治疗:新视角

Aisha H. Al-Shehri, Ahmed M. Kabel, M. A. A. Elmaaboud
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引用次数: 1

摘要

姜黄素是一种天然的黄色酚类化合物,存在于许多类型的草药中,尤其是姜黄。它是一种天然的抗氧化剂,在临床前和临床研究中显示出许多抗氧化、抗微生物、抗癌和抗阿尔茨海默病的作用。此外,姜黄素已被证明具有抗糖尿病、保肝、保神经、抗风湿等作用,还能预防血栓形成和心肌梗死。姜黄素在临床应用的主要限制是其极低的口服生物利用度。因此,已经开发和实现了许多技术来克服这一限制。本文综述了姜黄素纳米系统的设计和开发的最新进展,包括脂质体、聚合物纳米颗粒、微偶联物、胶束、肽载体、固体分散体、环糊精、乳状体和脂质纳米肽,以及它们在癌症治疗中的作用。
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The Nanoformulations of Curcumin for Cancer Therapy: New Perspectives
Curcumin is a natural yellow phenolic compound that is located in many types of herbs, especially Curcuma Lana (Turmeric). It is a natural anti-oxidant and has shown many pharmaceutical activities in the preclinical and clinical studies such as antioxidant, anti-microbial, anti-cancer and anti-alzheimer disease effects. In addition, curcumin was proven to be anti-diabetic, hepatoprotective, neuroprotective and anti-rheumatic and it also protects against thrombosis and myocardial infarction. The major limitation to the use of curcumin in clinical practice is its very low oral bioavailability. Therefore, many technologies have been developed and implemented to overcome this limitation. In this review, we discussed the latest perspectives regarding the design and development of nano-sized systems for the anti-diabetic agent curcumin, including liposomes, polymeric nanoparticles, micro-conjugates, micelles, peptide carriers, solid dispersions, cyclodextrins, emulsions and lipid nanopeptides and their role as a promising hope for cancer therapy.
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