Emmanuel Eilu, S. Akinola, Julius Tibyangye, R. O. Adeyemo, Martin Odoki, A. Adamu, Sarah Kemuma Onkoba, Moindi Jeridah Kemunto, Ismail Adebayo Abyola, C. Kato
Alternative techniques for detecting cancer of the cervix uteri alongside its early precancerous lesions still remain necessary for low income environments since morbidity and mortality due to cervical cancer continues to be on the rise. We recruited one thousand and seventy-seven women aged 15-55 years from selected study hospitals in Eastern Uganda and examined them using Papanicolaou (Pap) smear, direct visual inspection with 5% acetic acid solution (VIA), and human papillomavirus (HPV) DNA testing. Study participants detected with high-grade lesions (HSIL) or cancer cells on Pap smear test, positive VIA test (acetowhite lesions, cervical ulcer or growth), and positive high-risk HPV DNA (relative light units (RLU) were immediately scheduled for colposcopy and cervical biopsy. Of the forty percent of the women confirmed with pap smear positive, 43 of the 63 women had invasive carcinoma (68.3%), while 89 out of 137 women with confirmed biopsy were diagnosed with high grade CIN (CIN2,3) (65%). DVI identified 46 of 63 carcinomas (73%) as well as 47 of 74 high grades CIN (CIN 2, 3) (64%). There was a variation in HPV DNA results due to the cutoff value considered in defining the final result. HPV DNA of high-risk HPV types was detected 39 (61.9%) out the 63 women diagnosed invasive cervical cancer, while 66 (73.3%) or 46 (51%) was detected in the biopsy of women diagnosed with high grade CIN (CIN 2,3). Similarity in identification of high-grade cervical abnormalities was registered by the testing methods. Both VIA and HPV genetic testing methods diagnosed similar numbers of high grade CIN 2,3 and invasive cancer cases as Pap smears. Nevertheless, individual test methods categorized study participants with no cervical disease as being positive. Key words: Visual inspection with acetic acid (VIA), cervical intraepithelial neoplasia (CIN), human papillomavirus (HPV).
{"title":"Assessment of alternative approaches of primary cervical cancer screening among women in low-income environments","authors":"Emmanuel Eilu, S. Akinola, Julius Tibyangye, R. O. Adeyemo, Martin Odoki, A. Adamu, Sarah Kemuma Onkoba, Moindi Jeridah Kemunto, Ismail Adebayo Abyola, C. Kato","doi":"10.5897/JCREO2020.0168","DOIUrl":"https://doi.org/10.5897/JCREO2020.0168","url":null,"abstract":"Alternative techniques for detecting cancer of the cervix uteri alongside its early precancerous lesions still remain necessary for low income environments since morbidity and mortality due to cervical cancer continues to be on the rise. We recruited one thousand and seventy-seven women aged 15-55 years from selected study hospitals in Eastern Uganda and examined them using Papanicolaou (Pap) smear, direct visual inspection with 5% acetic acid solution (VIA), and human papillomavirus (HPV) DNA testing. Study participants detected with high-grade lesions (HSIL) or cancer cells on Pap smear test, positive VIA test (acetowhite lesions, cervical ulcer or growth), and positive high-risk HPV DNA (relative light units (RLU) were immediately scheduled for colposcopy and cervical biopsy. Of the forty percent of the women confirmed with pap smear positive, 43 of the 63 women had invasive carcinoma (68.3%), while 89 out of 137 women with confirmed biopsy were diagnosed with high grade CIN (CIN2,3) (65%). DVI identified 46 of 63 carcinomas (73%) as well as 47 of 74 high grades CIN (CIN 2, 3) (64%). There was a variation in HPV DNA results due to the cutoff value considered in defining the final result. HPV DNA of high-risk HPV types was detected 39 (61.9%) out the 63 women diagnosed invasive cervical cancer, while 66 (73.3%) or 46 (51%) was detected in the biopsy of women diagnosed with high grade CIN (CIN 2,3). Similarity in identification of high-grade cervical abnormalities was registered by the testing methods. Both VIA and HPV genetic testing methods diagnosed similar numbers of high grade CIN 2,3 and invasive cancer cases as Pap smears. Nevertheless, individual test methods categorized study participants with no cervical disease as being positive. \u0000 \u0000 Key words: Visual inspection with acetic acid (VIA), cervical intraepithelial neoplasia (CIN), human papillomavirus (HPV).","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"130 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89467976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Sexuаlity is an important part of normal human functioning. Causes of sexual dysfunction following cervical cancer treatments may be multi-factoriаl but it may often result from the direct effects of the treatment. Aim: study the impаct of an educational program on sexual dysfunction of women with cervical cancer Methods; Design: А quаsi-experimental design. Setting: out-patient clinic in the oncology unit at Beni-Suef University Hospitаl. Subjects: А purposive sample of 70 women. Tools: structured interviewing questionnaire sheet, and а femаle sexual function index. Results: The results of the study progression and improvement of all items of women’s Sexual Function Index (Desire, Аrousаl, Lubricаtion, Orgаsm, Sаtisfаction, and Pain) post-program compаred to pre-one. Conclusion: The teaching program was very effective in improving sexuality for women with cervicаl cancer. Recommendations: Women's counseling activities regarding cervicаl cаncer, and sexuality need to be popularized and facilities and decision-mаking аids mаde available to those who need them.
{"title":"Impact of an Educational Program on Sexual Dysfunction Associated With Cervical Cancer","authors":"H. Hassan, Ragaa Ali, S. A. E. Salam, Hagar Kamal","doi":"10.12691/JCRT-9-2-1","DOIUrl":"https://doi.org/10.12691/JCRT-9-2-1","url":null,"abstract":"Background: Sexuаlity is an important part of normal human functioning. Causes of sexual dysfunction following cervical cancer treatments may be multi-factoriаl but it may often result from the direct effects of the treatment. Aim: study the impаct of an educational program on sexual dysfunction of women with cervical cancer Methods; Design: А quаsi-experimental design. Setting: out-patient clinic in the oncology unit at Beni-Suef University Hospitаl. Subjects: А purposive sample of 70 women. Tools: structured interviewing questionnaire sheet, and а femаle sexual function index. Results: The results of the study progression and improvement of all items of women’s Sexual Function Index (Desire, Аrousаl, Lubricаtion, Orgаsm, Sаtisfаction, and Pain) post-program compаred to pre-one. Conclusion: The teaching program was very effective in improving sexuality for women with cervicаl cancer. Recommendations: Women's counseling activities regarding cervicаl cаncer, and sexuality need to be popularized and facilities and decision-mаking аids mаde available to those who need them.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"16 1","pages":"22-31"},"PeriodicalIF":0.0,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87324153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Cervical cancer is the 4th most frequent cancer in women. Aim: The present study aimed to assess self-knowledge among women with cervical cancer. Methods; Design: A descriptive research design was used. Setting: out-patient clinic in the oncology unit at Beni-Suef University Hospital. Subjects: A purposive sample of 70 women. Tools: Data was collected through a structured interviewing questionnaire sheet and a scoring system for women’s knowledge about cervical cancer. Results: The results of the study revealed that there was a statistically significant difference in the women's knowledge about cervical cancer, and socio-demographic characteristics. Conclusion: The study concluded that socio-demographic characteristics of women could affect their knowledge level regarding cervical cancer. Recommendations: Implement an educational program and disseminate information that focuses on educating women about cervical cancer risks, prevention, and early detection to enhance uptake of cervical cancer.
{"title":"Self-Knowledge among Women with Cervical Cancer","authors":"Hagar Kamal, Ragaa Ali, S. A. E. Salam, H. Hassan","doi":"10.12691/JCRT-9-1-2","DOIUrl":"https://doi.org/10.12691/JCRT-9-1-2","url":null,"abstract":"Background: Cervical cancer is the 4th most frequent cancer in women. Aim: The present study aimed to assess self-knowledge among women with cervical cancer. Methods; Design: A descriptive research design was used. Setting: out-patient clinic in the oncology unit at Beni-Suef University Hospital. Subjects: A purposive sample of 70 women. Tools: Data was collected through a structured interviewing questionnaire sheet and a scoring system for women’s knowledge about cervical cancer. Results: The results of the study revealed that there was a statistically significant difference in the women's knowledge about cervical cancer, and socio-demographic characteristics. Conclusion: The study concluded that socio-demographic characteristics of women could affect their knowledge level regarding cervical cancer. Recommendations: Implement an educational program and disseminate information that focuses on educating women about cervical cancer risks, prevention, and early detection to enhance uptake of cervical cancer.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"13 1","pages":"12-21"},"PeriodicalIF":0.0,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78291570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-08DOI: 10.12677/WJCR.2021.111003
海祥 林
{"title":"Open the Therapeutic Revolution Door of Antiviral Antitumor by Improving Systemic Non-Specific Immunity","authors":"海祥 林","doi":"10.12677/WJCR.2021.111003","DOIUrl":"https://doi.org/10.12677/WJCR.2021.111003","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76356975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2684-1266.21.7.E108
M. Oaks
{"title":"Peripheral Stem Cell Transplantation and its Complications","authors":"M. Oaks","doi":"10.35248/2684-1266.21.7.E108","DOIUrl":"https://doi.org/10.35248/2684-1266.21.7.E108","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"25 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75186786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2684-1266.21.7.131
K. Palan
{"title":"Aggressive Systemic Mastocytosis: Types, Symptoms, Diagnosis and Treatment","authors":"K. Palan","doi":"10.35248/2684-1266.21.7.131","DOIUrl":"https://doi.org/10.35248/2684-1266.21.7.131","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"1 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78358194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.12677/WJCR.2021.111001
魏 冬梅
{"title":"A Study of the Effects of Yangyin Fuzheng Decoction on HIF-1α and Arg1 Expression in Lung Cancer Mice Based on Acidic Microenvironment","authors":"魏 冬梅","doi":"10.12677/WJCR.2021.111001","DOIUrl":"https://doi.org/10.12677/WJCR.2021.111001","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"25 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81207073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2684-1266.21.7.134
Xun Li
{"title":"Non-melanoma Skin Cancer: Types, Symptoms, Causes and Treatment","authors":"Xun Li","doi":"10.35248/2684-1266.21.7.134","DOIUrl":"https://doi.org/10.35248/2684-1266.21.7.134","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"53 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76814083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.12677/WJCR.2021.112005
俊芳 朱
{"title":"Research Progress of Electrochemical Biosensor for Detecting Exosomes","authors":"俊芳 朱","doi":"10.12677/WJCR.2021.112005","DOIUrl":"https://doi.org/10.12677/WJCR.2021.112005","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"38 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86088257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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