YKL-40在健康和疾病:对关节炎症的挑战

M. Kazakova, V. Sarafian
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引用次数: 9

摘要

在不同类型的关节炎中,需要生物标志物来检测早期关节炎症和软骨破坏。YKL-40是最近发现的一种39kd的肝素和几丁质结合分泌糖蛋白(也称为软骨gp39)。其确切的生物学功能尚不清楚。YKL-40的特异性受体尚未确定。本文从不同方面探讨了YKL-40作为生物标志物的临床意义。高水平的YKL-40在各种与炎症和肿瘤过程相关的人类疾病中被发现。本文综述了关于YKL-40的现有信息及其在炎性关节疾病中的意义。我们认为这种糖蛋白作为一种新的生物标志物可能具有很好的价值,并且可以为不同类型关节炎的炎症活性提供额外的证据。生物医学评论,2013,24(4):49-56。
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YKL-40 in health and disease: a challenge for joint inflammation
There is a need of biomarkers to detect early joint inflammation and destruction of cartilage in different types of arthritis. YKL-40, a 39 kD heparin- and chitin-binding secreted glycoprotein (also known as cartilage gp39), was recently discovered. Its exact biological function is still unclear. Specific receptors for YKL-40 have not been identified yet. The clinical significance of YKL-40 as a biomarker is discussed in different aspects. High level of YKL-40 was found in various human diseases associated with inflammatory and neoplastic processes. The review highlights the information available about YKL-40 and its significance in inflammatory joint diseases. We suggest that this glycoprotein might have a promising value as a novel biomarker and could provide additional evidence for inflammation activity in different types of arthritis. Biomedical Reviews 2013, 24: 49-56.
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