{"title":"YKL-40在健康和疾病:对关节炎症的挑战","authors":"M. Kazakova, V. Sarafian","doi":"10.14748/BMR.V24.21","DOIUrl":null,"url":null,"abstract":"There is a need of biomarkers to detect early joint inflammation and destruction of cartilage in different types of arthritis. YKL-40, a 39 kD heparin- and chitin-binding secreted glycoprotein (also known as cartilage gp39), was recently discovered. Its exact biological function is still unclear. Specific receptors for YKL-40 have not been identified yet. The clinical significance of YKL-40 as a biomarker is discussed in different aspects. High level of YKL-40 was found in various human diseases associated with inflammatory and neoplastic processes. The review highlights the information available about YKL-40 and its significance in inflammatory joint diseases. We suggest that this glycoprotein might have a promising value as a novel biomarker and could provide additional evidence for inflammation activity in different types of arthritis. Biomedical Reviews 2013, 24: 49-56.","PeriodicalId":8906,"journal":{"name":"Biomedical Reviews","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2013-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":"{\"title\":\"YKL-40 in health and disease: a challenge for joint inflammation\",\"authors\":\"M. Kazakova, V. Sarafian\",\"doi\":\"10.14748/BMR.V24.21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"There is a need of biomarkers to detect early joint inflammation and destruction of cartilage in different types of arthritis. YKL-40, a 39 kD heparin- and chitin-binding secreted glycoprotein (also known as cartilage gp39), was recently discovered. Its exact biological function is still unclear. Specific receptors for YKL-40 have not been identified yet. The clinical significance of YKL-40 as a biomarker is discussed in different aspects. High level of YKL-40 was found in various human diseases associated with inflammatory and neoplastic processes. The review highlights the information available about YKL-40 and its significance in inflammatory joint diseases. We suggest that this glycoprotein might have a promising value as a novel biomarker and could provide additional evidence for inflammation activity in different types of arthritis. Biomedical Reviews 2013, 24: 49-56.\",\"PeriodicalId\":8906,\"journal\":{\"name\":\"Biomedical Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14748/BMR.V24.21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14748/BMR.V24.21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
YKL-40 in health and disease: a challenge for joint inflammation
There is a need of biomarkers to detect early joint inflammation and destruction of cartilage in different types of arthritis. YKL-40, a 39 kD heparin- and chitin-binding secreted glycoprotein (also known as cartilage gp39), was recently discovered. Its exact biological function is still unclear. Specific receptors for YKL-40 have not been identified yet. The clinical significance of YKL-40 as a biomarker is discussed in different aspects. High level of YKL-40 was found in various human diseases associated with inflammatory and neoplastic processes. The review highlights the information available about YKL-40 and its significance in inflammatory joint diseases. We suggest that this glycoprotein might have a promising value as a novel biomarker and could provide additional evidence for inflammation activity in different types of arthritis. Biomedical Reviews 2013, 24: 49-56.