Effects of Perfluorooctane Sulfonate on Carassius aurats and Kinetics Models

This study investigated the effects of perfluorooctane sulfonate (PFOS) exposure for varying durations and at multiple concentrations to Carassius aurats on tissues and organs (plasma, liver, kidney, muscle, and brain) and reproductive hormone (plasma testosterone, 11-ketotestoterone, 17β-estradiol) and cell performance (membrane fluidity and potential), as well as kinetics models. The results showed that plasma PFOS concentrations were higher than those in other tissues, brains presented significantly lower PFOS concentrations than in other tissues, different ranking of mean tissue concentrations: plasma > liver > kidney > muscle > brain. PFOS caused significant decrease in serum cholesterol levels compared to control levels (P .05). Continuous incubation time induced a further decrease in serum cholesterol in Carassius aurats. Circulating testosterone was significantly depressed in male ...