Pub Date : 2009-08-18DOI: 10.1080/14634980902908506
S. Ganta, Sandra Chadwick, Dipti Deshpande, M. Amiji
ABSTRACT Biomedical nanotechnology promises to play an important role in disease prevention, early diagnosis, and more effective treatment strategies. Development of nanosized concepts that can be used for improved vaccine delivery, image contrast enhancers for sensitive and specific disease detection, and targeted therapeutic strategies for drug and genes holds tremendous promise in cost-effective patient care and improving clinical outcomes. One of the critical areas in the development of nanotechnology is to emphasize the role of eco-friendly approaches in synthesis and fabrication, storage, utilization, and reduction of toxicity especially for medically relevant applications. Integration of “green” concepts with biomedical product development can have a profound influence in the future. In this review, the authors discuss various eco-friendly strategies that can be implemented for more effective use of raw materials, avoidance of toxic chemicals and hazardous solvents, and substantial reduction of tox...
{"title":"Role of Eco-Friendly Strategies in the Development of Biomedical Nanotechnology","authors":"S. Ganta, Sandra Chadwick, Dipti Deshpande, M. Amiji","doi":"10.1080/14634980902908506","DOIUrl":"https://doi.org/10.1080/14634980902908506","url":null,"abstract":"ABSTRACT Biomedical nanotechnology promises to play an important role in disease prevention, early diagnosis, and more effective treatment strategies. Development of nanosized concepts that can be used for improved vaccine delivery, image contrast enhancers for sensitive and specific disease detection, and targeted therapeutic strategies for drug and genes holds tremendous promise in cost-effective patient care and improving clinical outcomes. One of the critical areas in the development of nanotechnology is to emphasize the role of eco-friendly approaches in synthesis and fabrication, storage, utilization, and reduction of toxicity especially for medically relevant applications. Integration of “green” concepts with biomedical product development can have a profound influence in the future. In this review, the authors discuss various eco-friendly strategies that can be implemented for more effective use of raw materials, avoidance of toxic chemicals and hazardous solvents, and substantial reduction of tox...","PeriodicalId":88525,"journal":{"name":"International journal of green nanotechnology. Biomedicine","volume":"1044 1","pages":"9-23"},"PeriodicalIF":0.0,"publicationDate":"2009-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77217981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-18DOI: 10.1080/19430850903149894
T. Bhowmick, A. Suresh, S. Kane, Ajit C. Joshi, J. Bellare
ABSTRACT Indian traditional medicine Jasada Bhasma is a unique particulate preparation of zinc, which has been used by traditional practitioners for the treatment of various diseases such as diabetes, eye diseases, etc. This paper is an attempt to understand the mode of action of this and related types of particulate matter in biology. The biological activity of Jasada Bhasma has been tested on Saccharomyces cerevisiae wild strain, chosen as a model eukaryotic system. Results show that Jasada Bhasma– treated yeast cells were able to maintain a higher level of growth over control. DNA and enzyme studies, together with advanced microscopic studies of cellular and nuclear morphology, suggest a protective action against cellular damage mediated by reactive oxygen species (ROS). Further, a nanoparticulate-size fraction of the Bhasma showed effects comparable to the unfractionated mass, at much lower dosage levels. In comparative studies, qualitatively similar effects were also exhibited by other compounds of z...
{"title":"Indian Traditional Medicine Jasada Bhasma and Other Zinc-Containing Nanoparticles Alleviate Reactive Oxygen Species–Mediated Cell Damage in Saccharomyces cerevisiae","authors":"T. Bhowmick, A. Suresh, S. Kane, Ajit C. Joshi, J. Bellare","doi":"10.1080/19430850903149894","DOIUrl":"https://doi.org/10.1080/19430850903149894","url":null,"abstract":"ABSTRACT Indian traditional medicine Jasada Bhasma is a unique particulate preparation of zinc, which has been used by traditional practitioners for the treatment of various diseases such as diabetes, eye diseases, etc. This paper is an attempt to understand the mode of action of this and related types of particulate matter in biology. The biological activity of Jasada Bhasma has been tested on Saccharomyces cerevisiae wild strain, chosen as a model eukaryotic system. Results show that Jasada Bhasma– treated yeast cells were able to maintain a higher level of growth over control. DNA and enzyme studies, together with advanced microscopic studies of cellular and nuclear morphology, suggest a protective action against cellular damage mediated by reactive oxygen species (ROS). Further, a nanoparticulate-size fraction of the Bhasma showed effects comparable to the unfractionated mass, at much lower dosage levels. In comparative studies, qualitatively similar effects were also exhibited by other compounds of z...","PeriodicalId":88525,"journal":{"name":"International journal of green nanotechnology. Biomedicine","volume":"55 1","pages":"69-89"},"PeriodicalIF":0.0,"publicationDate":"2009-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86468094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-18DOI: 10.1080/14634980902908514
Y. Qazi, Brian C. Stagg, B. Ambati
ABSTRACT Over the past decade, nanoparticles have risen to the forefront of biotechnology, promising diverse applications in the fields of gene therapy, drug delivery, and imaging. Nanoparticles can be engineered to create optimal features that are tissue-specific or target-orientated to promote their uptake, clearance, biodegradability, reduced immunogenicity, and detection. Nanomedicine offers potentially safe and successful treatment regimens for ocular disorders. In this review, the authors focus on the ophthalmic applications of nanoparticles, with particular attention to gene therapy and drug delivery.
{"title":"Nanoparticles in Ophthalmic Medicine","authors":"Y. Qazi, Brian C. Stagg, B. Ambati","doi":"10.1080/14634980902908514","DOIUrl":"https://doi.org/10.1080/14634980902908514","url":null,"abstract":"ABSTRACT Over the past decade, nanoparticles have risen to the forefront of biotechnology, promising diverse applications in the fields of gene therapy, drug delivery, and imaging. Nanoparticles can be engineered to create optimal features that are tissue-specific or target-orientated to promote their uptake, clearance, biodegradability, reduced immunogenicity, and detection. Nanomedicine offers potentially safe and successful treatment regimens for ocular disorders. In this review, the authors focus on the ophthalmic applications of nanoparticles, with particular attention to gene therapy and drug delivery.","PeriodicalId":88525,"journal":{"name":"International journal of green nanotechnology. Biomedicine","volume":"128 1","pages":"3-8"},"PeriodicalIF":0.0,"publicationDate":"2009-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88070142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-18DOI: 10.1080/19430850903149803
Zhaoxiang Han, Chun-xia Lv, Zeng-ren Zheng
This study investigated the effects of perfluorooctane sulfonate (PFOS) exposure for varying durations and at multiple concentrations to Carassius aurats on tissues and organs (plasma, liver, kidney, muscle, and brain) and reproductive hormone (plasma testosterone, 11-ketotestoterone, 17β-estradiol) and cell performance (membrane fluidity and potential), as well as kinetics models. The results showed that plasma PFOS concentrations were higher than those in other tissues, brains presented significantly lower PFOS concentrations than in other tissues, different ranking of mean tissue concentrations: plasma > liver > kidney > muscle > brain. PFOS caused significant decrease in serum cholesterol levels compared to control levels (P .05). Continuous incubation time induced a further decrease in serum cholesterol in Carassius aurats. Circulating testosterone was significantly depressed in male ...
{"title":"Effects of Perfluorooctane Sulfonate on Carassius aurats and Kinetics Models","authors":"Zhaoxiang Han, Chun-xia Lv, Zeng-ren Zheng","doi":"10.1080/19430850903149803","DOIUrl":"https://doi.org/10.1080/19430850903149803","url":null,"abstract":"This study investigated the effects of perfluorooctane sulfonate (PFOS) exposure for varying durations and at multiple concentrations to Carassius aurats on tissues and organs (plasma, liver, kidney, muscle, and brain) and reproductive hormone (plasma testosterone, 11-ketotestoterone, 17β-estradiol) and cell performance (membrane fluidity and potential), as well as kinetics models. The results showed that plasma PFOS concentrations were higher than those in other tissues, brains presented significantly lower PFOS concentrations than in other tissues, different ranking of mean tissue concentrations: plasma > liver > kidney > muscle > brain. PFOS caused significant decrease in serum cholesterol levels compared to control levels (P .05). Continuous incubation time induced a further decrease in serum cholesterol in Carassius aurats. Circulating testosterone was significantly depressed in male ...","PeriodicalId":88525,"journal":{"name":"International journal of green nanotechnology. Biomedicine","volume":"49 1","pages":"60-68"},"PeriodicalIF":0.0,"publicationDate":"2009-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91200410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-18DOI: 10.1080/19430850902908522
C. Mohanty, Geeta Arya, R. Verma, S. Sahoo
ABSTRACT Nanobiotechnology is a recently coined term describing the convergence of the two existing but distant worlds of engineering and molecular biology. Nanobiotechnology is the interface between nanotechnology and biology. This is a combination of three words: NANO is tiny, BIO is living things, and TECHNOLOGY is about tools. It is an emerging area of scientific and technological advancement. Nanobiotechnology refers to the ability to create and manipulate biological and biochemical materials, devices, and systems at atomic and molecular levels (billionth of a meter). Thus, it is an integration of physical sciences, molecular engineering, biology, chemistry, and biotechnology, and holds considerable promise of advances in pharmaceuticals and health care. Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Their unique size-dependent properties make these materials superior, indispensable in many areas of human activity, and above all a tiny tool to learn about liv...
{"title":"Nanobiotechnology: Application of Nanotechnology in Therapeutics and Diagnosis","authors":"C. Mohanty, Geeta Arya, R. Verma, S. Sahoo","doi":"10.1080/19430850902908522","DOIUrl":"https://doi.org/10.1080/19430850902908522","url":null,"abstract":"ABSTRACT Nanobiotechnology is a recently coined term describing the convergence of the two existing but distant worlds of engineering and molecular biology. Nanobiotechnology is the interface between nanotechnology and biology. This is a combination of three words: NANO is tiny, BIO is living things, and TECHNOLOGY is about tools. It is an emerging area of scientific and technological advancement. Nanobiotechnology refers to the ability to create and manipulate biological and biochemical materials, devices, and systems at atomic and molecular levels (billionth of a meter). Thus, it is an integration of physical sciences, molecular engineering, biology, chemistry, and biotechnology, and holds considerable promise of advances in pharmaceuticals and health care. Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Their unique size-dependent properties make these materials superior, indispensable in many areas of human activity, and above all a tiny tool to learn about liv...","PeriodicalId":88525,"journal":{"name":"International journal of green nanotechnology. Biomedicine","volume":"9 1","pages":"24-38"},"PeriodicalIF":0.0,"publicationDate":"2009-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90224441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-08-18DOI: 10.1080/19430850903149936
Luis R. Reyes, I. Gómez, Marianela Garza
ABSTRACT CdS nanoparticles have attracted attention due to its optical and electrical properties. Conventional methods provide some problems, such as particle size, high-pressure requirements, and the use of toxic materials, for its synthesis. It is well known that many microorganisms can provide inorganic materials either intra- as extracellularly. In this work, the authors present the results of the CdS nanoparticles synthesis using Fusarium sp. biomass as a sustainable synthesis procedure, after its exposition with a CdSO4 solution. Nanoparticles were characterized by ultraviolet-visible, x-ray diffraction, and atomic force microscopy.
{"title":"Biosynthesis of Cadmium Sulfide Nanoparticles by the Fungi Fusarium sp.","authors":"Luis R. Reyes, I. Gómez, Marianela Garza","doi":"10.1080/19430850903149936","DOIUrl":"https://doi.org/10.1080/19430850903149936","url":null,"abstract":"ABSTRACT CdS nanoparticles have attracted attention due to its optical and electrical properties. Conventional methods provide some problems, such as particle size, high-pressure requirements, and the use of toxic materials, for its synthesis. It is well known that many microorganisms can provide inorganic materials either intra- as extracellularly. In this work, the authors present the results of the CdS nanoparticles synthesis using Fusarium sp. biomass as a sustainable synthesis procedure, after its exposition with a CdSO4 solution. Nanoparticles were characterized by ultraviolet-visible, x-ray diffraction, and atomic force microscopy.","PeriodicalId":88525,"journal":{"name":"International journal of green nanotechnology. Biomedicine","volume":"7 1","pages":"90-95"},"PeriodicalIF":0.0,"publicationDate":"2009-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84305532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1080/19430850902931599
Kavita Katti, Nripen Chanda, Ravi Shukla, Ajit Zambre, Thilakavathi Suibramanian, Rajesh R Kulkarni, Raghuraman Kannan, Kattesh V Katti
ABSTRACT The powerful antioxidant characteristics of various phytochernicals within cumin prompted us to test their efficacy in reducing sodium tetrachloroaurate to corresponding gold nanoparticles. We, herein, report an unprecedented synthetic route that involves the production of well-defined spherical gold nanoparticles by simple mixing of cumin to an aqueous solution of sodium tetrachloro aurate. Production of gold nanoparticles in this cumin–mediated Green Nanotechnological process is achieved under biologically benign conditions. The gold nanoparticles generated through cumin-mediated process did not aggregate suggesting that the cocktail of phytochemicals including proteins serve as excellent coatings on nanoparticles and thus, provide robust shielding from aggregations. In addition, the phytochemical coatings on nanoparticles have rendered nontoxic features to these ‘Green Gold Nanoparticles’ as demonstrated through detailed MTT assays performed on 'normal fibroblast cells. Results of our studies ...
{"title":"Green Nanotechnology from Cumin Phytochemicals: Generation of Biocompatible Gold Nanoparticles.","authors":"Kavita Katti, Nripen Chanda, Ravi Shukla, Ajit Zambre, Thilakavathi Suibramanian, Rajesh R Kulkarni, Raghuraman Kannan, Kattesh V Katti","doi":"10.1080/19430850902931599","DOIUrl":"https://doi.org/10.1080/19430850902931599","url":null,"abstract":"ABSTRACT The powerful antioxidant characteristics of various phytochernicals within cumin prompted us to test their efficacy in reducing sodium tetrachloroaurate to corresponding gold nanoparticles. We, herein, report an unprecedented synthetic route that involves the production of well-defined spherical gold nanoparticles by simple mixing of cumin to an aqueous solution of sodium tetrachloro aurate. Production of gold nanoparticles in this cumin–mediated Green Nanotechnological process is achieved under biologically benign conditions. The gold nanoparticles generated through cumin-mediated process did not aggregate suggesting that the cocktail of phytochemicals including proteins serve as excellent coatings on nanoparticles and thus, provide robust shielding from aggregations. In addition, the phytochemical coatings on nanoparticles have rendered nontoxic features to these ‘Green Gold Nanoparticles’ as demonstrated through detailed MTT assays performed on 'normal fibroblast cells. Results of our studies ...","PeriodicalId":88525,"journal":{"name":"International journal of green nanotechnology. Biomedicine","volume":"1 1","pages":"B39-B52"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19430850902931599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28489705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.1080/19430850902983848
Kavita K Katti, Vijaya Kattumuri, Sharanya Bhaskaran, Kattesh V Katti, Raghuraman Kannan
This letter describes a general method for the preparation of carbohydrate coated gold nanoparticles. The generality of this method has been demonstrated by surface coating AuNPs with the following sugars: glucose (monosaccharide); sucrose, maltose, or lactose (disaccharides); raffinose (trisaccharide); and starch (polysaccharide). The non-toxic, water-soluble phosphino aminoacid P(CH(2)NHCH(CH(3)-)COOH)(3), THPAL, has been used as a reducing agent in this process. The sizes of sugar coated AuNPs that have been generated in this study are: 30 ± 8 nm (Glucose), 10 ± 6 nm (sucrose), 8 ± 2 nm (maltose), 3 ± 1 nm (lactose), 6 ± 2 nm (raffinose), and 39 ± 9 nm (starch).
{"title":"Facile and General Method for Synthesis of Sugar Coated Gold Nanoparticles.","authors":"Kavita K Katti, Vijaya Kattumuri, Sharanya Bhaskaran, Kattesh V Katti, Raghuraman Kannan","doi":"10.1080/19430850902983848","DOIUrl":"10.1080/19430850902983848","url":null,"abstract":"<p><p>This letter describes a general method for the preparation of carbohydrate coated gold nanoparticles. The generality of this method has been demonstrated by surface coating AuNPs with the following sugars: glucose (monosaccharide); sucrose, maltose, or lactose (disaccharides); raffinose (trisaccharide); and starch (polysaccharide). The non-toxic, water-soluble phosphino aminoacid P(CH(2)NHCH(CH(3)-)COOH)(3), THPAL, has been used as a reducing agent in this process. The sizes of sugar coated AuNPs that have been generated in this study are: 30 ± 8 nm (Glucose), 10 ± 6 nm (sucrose), 8 ± 2 nm (maltose), 3 ± 1 nm (lactose), 6 ± 2 nm (raffinose), and 39 ± 9 nm (starch).</p>","PeriodicalId":88525,"journal":{"name":"International journal of green nanotechnology. Biomedicine","volume":"1 1","pages":"B53-B59"},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790171/pdf/nihms135546.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28595122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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