高渗盐水洗鼻漱口作为一种廉价实用的辅助武器对抗无症状的SARS-CoV-2感染。病例报告

Paola Rosati, U. Giordano, C. Concato
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引用次数: 7

摘要

背景:意大利、西欧、美国以及世界上其他发展中国家的预防政策和有害的封锁似乎无法控制严重急性呼吸综合征冠状病毒2 (COVID-19)的重症监护负担和死亡,特别是在养老院。由于现有证据有限,我们想知道为什么到目前为止只有一篇出版物(JAMA耳鼻喉头颈外科doi:10.1001/jamaoto.2020.1622)记录了用高渗盐水(一种盐浓度为正渗盐水三到四倍的溶液)反复漱口和漱口如何迅速成为当前卫生政策的一种无成本辅助武器,用于在早期阶段对抗新型冠状病毒2019 (SARS-CoV-2)感染,也适用于被隔离的人群。在发展中国家也是如此。病例介绍:我们报告了一名54岁无症状的SARS-CoV-2感染医生(鼻咽拭子试验阳性)在罗马被隔离的病例,该病例每天在家多次高渗盐水鼻冲洗和漱口引起了快速成功的反应。感染医师无症状,感染2个月后血清sars - cov - IgG检测呈阴性。讨论和结论:我们的病例报告描述了SARS-CoV-2感染后两个多月的血清IgG阴性,似乎支持了最近的证据,即无症状患者早期用高渗盐水治疗可避免多器官炎症,需要重症监护。在目前的紧急状态下,卫生当局可以提倡高渗盐水鼻冲洗和漱口,作为一种廉价的辅助措施,以“清除”SARS-CoV-2。这种经过验证的、通常安全的生理盐水权宜之计可能有助于作为一种辅助武器,如洗手,在发达国家和发展中国家早期对抗SARS-CoV-2感染,或在第二波COVID-19中回归。
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Hypertonic saline nasal irrigation and gargling as an inexpensive practical adjunctive weapon to combat asymptomatic SARS-CoV-2 infections. A case report
Background: Preventive policies and harmful lockdowns in Italy, Western Europe, the United States, as well as in other developing countries worldwide seem unable to contain the intensive care burden and deaths for severe acute respiratory syndrome coronavirus 2 (COVID-19), especially in nursing homes. Prompted by the limited evidence available, we wonder why until now only one publication (JAMA Otolaryngol Head Neck Surg doi:10.1001/jamaoto.2020.1622) has documented how repetitive nasal rinsing and gargling with hypertonic saline (a solution three to four times as salty as normotonic saline) could quickly contribute as an adjunctive cost-free weapon to current health policies for use against new coronavirus 2019 (SARS-CoV-2) infections at an early stage, also in quarantined people, and in developing countries. Case presentation: We report the case of a 54-year-old asymptomatic SARS-CoV-2 infected physician (positive nasopharyngeal swab test) quarantined in Rome in whom hypertonic saline nasal rinsing and gargling several times a day at home induced a rapid successful response. The infected physician remained asymptomatic, and serum immunoglobulin IgG for SARS-CoV-2 tested negative two months after the infection. Discussion and conclusions: Our case report, describing at more than two months after the SARS-CoV-2 infection negative serum IgG, seemingly supports recent evidence suggesting that asymptomatic subjects treated early with hypertonic saline solutions avoid multi-organ inflammation needing intensive care. In the current urgency state, health authorities could advocate hypertonic saline nasal rinsing and gargling as an adjunctive inexpensive procedure for SARS-CoV-2 “wash-out”. This proven, generally safe saline expedient might help as an adjunctive weapon like handwashing to combat the SARS-CoV-2 infection early in developed and developing countries, or returning as second COVID-19 waves.
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