Petar Kalaydzhiev , Nikolay Poroyliev , Desislava Somleva , Radostina Ilieva , Dimitar Markov , Elena Kinova , Asen Goudev
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引用次数: 2
摘要
睡眠障碍是心力衰竭患者常见的合并症。我们研究的目的是确定超重心力衰竭加重患者睡眠呼吸暂停的发生率和表型特征,并评估个体组收缩和舒张功能受损的程度。从2015年至2017年我科筛查的100名心力衰竭患者中,有61人符合纳入标准并参与了研究。82%(n=50)的患者患有阻塞性睡眠呼吸暂停(OSA),18%(n=11)患有中枢性睡眠呼吸中止(CSA)。CSA组的左心室射血分数(LVEF)显著低于OSA组(EF%49.6±8.5 vs 41.8±11.4;p=0.013)。LVEF与中心性呼吸暂停事件数呈负相关(r=-0.52;p<;0.001)。CSA组因心力衰竭(HF)住院的频率更高,死亡率更高。筛查心力衰竭和肥胖加重患者的睡眠呼吸暂停对于这些患者的复杂治疗是必要的。
Sleep apnea in patients with exacerbated heart failure and overweight
Sleep disorders are a common concomitant comorbidity in patients with heart failure. The aims of our study are to determine the incidence and phenotypic characteristics of sleep apnea in overweight patients with exacerbated heart failure and to assess the degree of involvement of systolic and diastolic function impairment in the individual group. From 100 screened patients with heart failure in our department from 2015 to 2017, 61 met the inclusion criteria and participated in the study. 82% (n = 50) of the patients had obstructive sleep apnea (OSA), and 18% (n = 11) had central sleep apnea (CSA). The CSA group had a significantly lower left ventricular ejection fraction (LVEF) than the OSA group (EF% 49.6 ± 8.5 vs 41.8 ± 11.4; p = 0.013). A negative correlation was found between LVEF and the number of central apnea events (r = −0.52; p < 0.001). More frequent hospitalizations for heart failure (HF) and higher mortality rate were found in the CSA group. Screening for sleep apnea in patients with exacerbated heart failure and obesity is necessary for the complex treatment of these patients.