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Mind at rest, mind at risk: A prospective population-based study of sleep and subsequent mental disorders
Q1 Medicine Pub Date : 2025-01-16 DOI: 10.1016/j.sleepx.2025.100138
Mari Hysing , Allison G. Harvey , Ann Kristin Skrindo Knudsen , Jens C. Skogen , Anne Reneflot , Børge Sivertsen

Background

Depression and anxiety disorders are highly prevalent among young adults, with evidence suggesting sleep problems as key risk factors.

Objective

This study aimed to examine the association between insomnia and sleep characteristics with major depressive episode (MDE) and anxiety disorders, and the association after accounting for baseline mental health symptoms.

Methods

We conducted a prospective cohort study using data from the Students’ Health and Wellbeing Study (SHoT), surveying Norwegian higher education students aged 18 to 35 (N = 53,362). A diagnostic assessment of 10,460 participants was conducted in 2023. Self-reported insomnia, sleep duration, sleep onset latency, and wake after sleep onset were recorded in 2022. MDE and five types of anxiety disorders were assessed after one year using a self-administered CIDI 5.0. Analyses adjusted for age, sex, baseline mental health symptoms, and somatic conditions.

Results

Insomnia in young adults was associated with a significantly increased risk of MDE (adjusted RR = 3.50, 95 % CI = 3.18–3.84) and generalized anxiety disorder (GAD) (adjusted RR = 2.82, 95 % CI = 2.55–3.12) one year later. Sleep duration showed a reversed J-shaped association with mental disorders, with both short and, to a lesser extent, long sleep durations linked to elevated risks, even after adjusting for baseline mental health symptoms and somatic conditions. Although the associations were attenuated after adjustment, they remained statistically significant.

Conclusion

Sleep disturbances, including insomnia and abnormal sleep durations, predict mental health issues in young adults, even after accounting for baseline mental health and somatic health. Addressing sleep problems early may help prevent subsequent mental health conditions in this population.
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引用次数: 0
Determinants of variations in sleep patterns across Brazil: Exploring geographic influences
Q1 Medicine Pub Date : 2024-12-20 DOI: 10.1016/j.sleepx.2024.100137
Giovana Longo-Silva , Renan Serenini , Roberto Antunes , Márcia Lima , Anny Pedrosa , Risia Menezes

Objective

To examine the influence of latitude, longitude, sunrise, and daylight, in conjunction with individual and behavioral factors, on sleep duration, wake time, and bedtime in a country with the world's broadest latitude range, yet characterized by homogeneity in language, cultural traits, and consistent time zones.

Methods

Participants (n = 1440; 18-65y) were part of a virtual population-based survey (2021–22). Sleep patterns were spatially represented through maps using Multilevel B-spline Interpolation. Relationships between and within biological/personal/socio-economic, behavioral and environment characteristics, and sleep outcomes were examined by Lasso regression. Restricted cubic splines were employed to examine the shape of the association of latitude and sunrise with sleep variables and of screen time before bed with bedtime.

Results

Latitude emerged as the primary geographic factor influencing variations in sleep duration and wake time, shortening and advancing, respectively, as latitude increased (towards equatorial line). Younger individuals, those living without partners, with depression, engaging in more frequent evening alcohol consumption, and with poorer diet quality, tended to wake up later. All the variables influenced bedtime, with daylight emerging as the environmental factor exerting the strongest association. While the variability in bedtime showed a non-linear association with latitude and sunrise, it displayed a dose-response relationship with screen time before bed.

Conclusions

Given that adults living in the same country, potentially with a similar timetable, could be having shorter sleep durations according to their latitude position, further studies are required to contemplate advocating for policies that implement schedules based on the sun position rather than the national time zone.
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引用次数: 0
Comparative efficacy of sodium oxybate versus placebo on improvement of nighttime sleep in adult patients with narcolepsy: A systematic review and meta-analysis 羟苯甲酸钠与安慰剂在改善成年嗜睡症患者夜间睡眠方面的疗效比较:系统回顾和荟萃分析。
Q1 Medicine Pub Date : 2024-12-19 DOI: 10.1016/j.sleepx.2024.100136
Adina Arshad , Muhammad Abdul Muqtadir Qureshi , Muhammad Abdullah Masood , Hafiz Shahbaz Zahoor , Ayesha Nazakat , Anfal Fatima , Javed Iqbal

Background

Narcolepsy, a central hypersomnolence disorder, disrupts sleep regulation. Sodium oxybate, a CNS (central nervous system) depressant, is widely used as a treatment, but there are surprisingly very few rigorous studies comparing its effectiveness to placebo in adults.

Objectives

To measure the comparative efficacy of sodium oxybate at a dosage regimen of 9 g versus placebo in improving nighttime sleep quality, reducing nocturnal arousals and sleep stage shifts, and enhancing the overall refreshed nature of sleep in adult patients with narcolepsy.

Methods

The methodology included a literature review of PubMed, Cochrane, Scopus, Google Scholar, and Clinicaltrials.gov, retrieving 53 randomized controlled trials (RCT) after removing 14 duplicates. Four studies met the criteria for gauging the efficacy of sodium oxybate compared to placebo in the adult population with narcolepsy. The primary efficacy outcome was improved sleep quality, whereas secondary outcomes were reduced nocturnal arousals and sleep stage shifts with an overall refreshed sleep nature. Analyses used RevMan 5.3 software, and SMD (standardized mean differences) with 95 % CI (confidence intervals) were calculated. Risk and publication biases were measured with Cochrane risk of bias tools and Comprehensive Meta-Analysis Software. Evidence certainty was measured using GRADEpro.

Results

Four RCT involving 1079 participants were analyzed for said outcomes, and relevant forest plots were generated. Statistical analysis showed a substantial improvement in sleep quality [SMD = 0.74(95%Cl:0.53,0.95; p < 0.00001; I2 = 0 %; (high certainty)] and refreshing nature of sleep [SMD = 0.81(95%CI:0.51,1.11; P < 0.00001; I2 = 0 %; (moderate certainty)], reduction in nocturnal arousals [SMD = −0.62(95%CI: 0.92,-0.32; p < 0.00001; I2 = 0 %; (moderate certainty)] and sleep stage shifts [SMD = −1.22(95%CI: 1.46,-0.98; p < 0.00001; I2 = 0 %; (high certainty)]. The risk of bias was located high for one study. Symmetrical funnel plots and Egger's regression intercepts testified to no significant publication bias.

Conclusions

The results showed that sodium oxybate considerably improved the quality of nocturnal sleep, resulting in substantial restorative advantages as well as a decrease in nocturnal arousals and sleep stage transitions. Significant results with low heterogeneity and p-values <0.05, showing consistent effects, were obtained from the analysis. However, overall reliability may be impacted by a high risk of bias in one study.
背景:嗜睡症是一种中枢性嗜睡障碍,破坏睡眠调节。氧酸钠是一种中枢神经系统抑制剂,被广泛用于治疗,但令人惊讶的是,很少有严谨的研究将其与安慰剂在成人中的效果进行比较。目的:比较9g剂量方案下的氧酸钠与安慰剂在改善成人发作性睡病患者夜间睡眠质量、减少夜间觉醒和睡眠阶段变化、增强整体睡眠精神状态方面的疗效。方法:纳入PubMed、Cochrane、Scopus、谷歌Scholar和Clinicaltrials.gov的文献综述,剔除14项重复,检索53项随机对照试验(RCT)。有四项研究符合衡量氧酸钠与安慰剂在成人嗜睡症患者中的疗效的标准。主要的疗效结果是改善睡眠质量,而次要的结果是减少夜间觉醒和睡眠阶段的变化,整体刷新睡眠性质。采用RevMan 5.3软件进行分析,计算SMD(标准化平均差异),95% CI(置信区间)。使用Cochrane风险偏倚工具和综合meta分析软件测量风险偏倚和发表偏倚。使用GRADEpro测量证据确定性。结果:对4项随机对照试验1079名受试者进行了上述结果分析,并生成了相关的森林样地。统计分析显示睡眠质量有明显改善[SMD = 0.74(95%Cl:0.53,0.95;p 2 = 0%;(高确定性)]和睡眠的清爽性[SMD = 0.81(95%CI:0.51,1.11;p 2 = 0%;(中度肯定)],夜间觉醒减少[SMD = -0.62(95%CI: 0.92,-0.32;p 2 = 0%;(中等确定性)]和睡眠阶段变化[SMD = -1.22(95%CI: 1.46,-0.98;p 2 = 0%;(高确定性)]。有一项研究的偏倚风险很高。对称漏斗图和Egger的回归截距证明没有显著的发表偏倚。结论:结果表明,氧化钠能显著改善夜间睡眠质量,具有明显的恢复性优势,并能减少夜间觉醒和睡眠阶段转换。具有低异质性和p值的显著结果
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引用次数: 0
Erratum to “Sleep body position correlates with cognitive performance in middle-old obstructive sleep apnea subjects” [Sleep Med: X 4 (2022) 100050]
Q1 Medicine Pub Date : 2024-12-15 DOI: 10.1016/j.sleepx.2024.100131
Sara Girolami, Marta Tardio, Serpetti Loredana, Nadia Di Mattia, Pamela Micheletti, Mario Di Napoli
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引用次数: 0
Erratum to “The importance of sleep studies in improving the health indices of a nation” [Sleep Med: X 4 (2022) 100049]
Q1 Medicine Pub Date : 2024-12-15 DOI: 10.1016/j.sleepx.2024.100130
Jitendra Kumar Sinha , Kshitij Vashisth , Shampa Ghosh
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引用次数: 0
Erratum to “Association of food intake with sleep disorders in children and adolescents with obesity” [Sleep Med: X 4 (2022) 100053]
Q1 Medicine Pub Date : 2024-12-15 DOI: 10.1016/j.sleepx.2024.100132
Raquel S.M. Zarpellon , Dra Regina M. Vilela , Fernando Mazzilli Louzada , Dra Rosana B. Radominski , Dra Ana Chrystina de Souza Crippa
{"title":"Erratum to “Association of food intake with sleep disorders in children and adolescents with obesity” [Sleep Med: X 4 (2022) 100053]","authors":"Raquel S.M. Zarpellon ,&nbsp;Dra Regina M. Vilela ,&nbsp;Fernando Mazzilli Louzada ,&nbsp;Dra Rosana B. Radominski ,&nbsp;Dra Ana Chrystina de Souza Crippa","doi":"10.1016/j.sleepx.2024.100132","DOIUrl":"10.1016/j.sleepx.2024.100132","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"8 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insomnia, cardiorespiratory function and quality of life in individuals with post-COVID-19 fatigue
Q1 Medicine Pub Date : 2024-11-27 DOI: 10.1016/j.sleepx.2024.100135
Nathalea Spode de Arruda , Alessandra Hofstadler Deiques Fleig , Charles Rech , Carine Cristina Callegaro

Objective

This study aimed to compare the prevalence of insomnia, lung function, inspiratory muscle function, functional capacity, and quality of life in individuals with and without post-COVID-19 fatigue.

Methods

Thirty-four post-COVID-19 individuals participated in the study, 20 with fatigue (32 ± 12 years old, 15% male) and 14 without fatigue (31 ± 12 years old, 42.9% male). The Chalder Fatigue Scale (CFS) was employed to categorize the volunteers into two groups: those with fatigue (score ≥4) and those without fatigue (score <4). The Insomnia Severity Index (ISI) and the Epworth Sleepiness Scale (ESS) were used to assess insomnia and excessive daytime sleepiness, respectively. Pulmonary function was evaluated by spirometry, inspiratory muscle strength was assessed by the maximum inspiratory pressure (MIP), and inspiratory endurance was evaluated by maintaining an inspiratory load of 60% of MIP until fatigue. The 6-min walk test (6MWT) was used to evaluated functional capacity, while the WHOQOL-BREF questionnaire assessed quality of life.

Results

Individuals with post-COVID-19 fatigue demonstrated a higher prevalence of insomnia (80% vs. 49%) and excessive daytime sleepiness (45% vs. 7%), as well as lower MIP, shorter distance covered in the 6MWT, and lower FEV1/FVC (forced expired volume in the first second divided by forced vital capacity), and FEV1/FVC% of predicted. Additionally, they exhibited poorer quality of life in the physical and environmental domains. CFS demonstrated a direct correlation with ISI (r=0.436, p=0.01) and ESS (r=0.593, p=0.001), as well as an inverse correlation with the distance covered in the 6MWT (r=-0.398, p=0.022) and FEV1 (r=-0.412, p=0.01). ISI was an independent predictor of CFS, with 62% of CFS variance explained by ISI variance.

Conclusion

Individuals with symptoms of post-COVID-19 fatigue may have a higher prevalence of insomnia, reduced inspiratory muscle strength, functional capacity, and Tiffeneau index, along with impaired quality of life. ISI is an independent predictor of post-COVID-19 fatigue.
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引用次数: 0
Poor sleep quality among bedtime smartphone user medical students in Ethiopia, 2024 埃塞俄比亚睡前使用智能手机的医学生睡眠质量差,2024 年
Q1 Medicine Pub Date : 2024-11-22 DOI: 10.1016/j.sleepx.2024.100134
Dereje Esubalew , Amare Mebrat Delie , Liknaw Workie Limenh , Nigus Kassie Worku , Eneyew Talie Fenta , Mickiale Hailu , Alemwork Abie , Molla Getie Mehari , Tenagnework Eseyneh Dagnaw , Mihret Melese

Background

Smartphone use has become widespread and continues to grow rapidly. Medical students, already highly susceptible to sleep deprivation, may experience exacerbated issues due to smartphone usage, particularly at bedtime. Therefore, understanding the potential negative impacts of this behavior is crucial. This study aims to assess the prevalence and risk factors of sleep quality among medical students bed time smart phone users in Ethiopia.

Subject and methods

An institutional-based cross-sectional study design was employed, involving 354 undergraduate medical students selected through simple random sampling from Debre Marko's University, the University of Gondar, and Debre Berhan University. Data were collected using the Pittsburgh Sleep Quality Index and structured interviews. Variables with a p-value of ≤0.2 in bivariable regression were included in multivariable logistic regression. Crude odds ratios and adjusted odds ratios were calculated, while chi-square tests were used to assess assumptions. In multivariable regression, variables with a p-value of ≤0.05 were deemed significant predictors at the 95 % confidence interval.

Result

The results showed that among bedtime smartphone users, 67.52 % had a poor sleep quality index greater than 5. Poor sleep quality was significantly linked to factors such as sex, regular coffee consumption, the purpose of smartphone use, phone position during use, the duration of smartphone use, and a history of disease. Social media usage was the most common activity, accounting for 41.60 % of smartphone use, followed by watching videos (21.65 %).

Conclusion

This study highlights the detrimental effects of bedtime smartphone use on sleep quality, which subsequently impacts mental. Given these findings, it is strongly recommended that medical students reduce their smartphone use before bedtime to improve their sleep quality.
背景智能手机的使用已经变得非常普遍,而且还在继续快速增长。医学生本来就很容易睡眠不足,使用智能手机(尤其是在睡前使用)可能会加剧他们的睡眠问题。因此,了解这种行为的潜在负面影响至关重要。本研究旨在评估埃塞俄比亚医科学生睡前使用智能手机的普遍程度和睡眠质量的风险因素。研究对象和方法采用基于院校的横断面研究设计,通过简单随机抽样从德布雷马尔科大学、贡德尔大学和德布雷贝汉大学选取了354名本科医科学生。采用匹兹堡睡眠质量指数和结构化访谈收集数据。在二变量回归中P值≤0.2的变量被纳入多变量逻辑回归。计算粗略的几率比例和调整后的几率比例,同时使用卡方检验来评估假设。结果结果显示,在睡前使用智能手机的人群中,67.52%的人睡眠质量差指数大于5。睡眠质量差与性别、经常喝咖啡、使用智能手机的目的、使用手机时的姿势、使用智能手机的时间长短以及疾病史等因素有明显关系。社交媒体使用是最常见的活动,占智能手机使用量的 41.60%,其次是观看视频(21.65%)。鉴于这些发现,强烈建议医学生减少睡前使用智能手机,以提高睡眠质量。
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引用次数: 0
Sleep quality and associated factors in adults living in the southern Brazil: A population-based study 巴西南部成年人的睡眠质量及相关因素:一项基于人口的研究
Q1 Medicine Pub Date : 2024-11-03 DOI: 10.1016/j.sleepx.2024.100133
Ernani Tiaraju de Santa Helena , Nicolas Boeira Machado , Rafael Tadao Sakae , Clovis Arlindo de Sousa , Carlos Roberto de Oliveira Nunes , Henry Völzke , Ralf Ewert , Marcello Ricardo Paulista Markus

Objective

To analyze sleep quality and associated socio-demographic and lifestyle factors in participants from a city originally colonised by Germans in southern Brazil.

Methods

A cross-sectional population-based study of 2333 individuals aged 20 to 79 years. Data was collected by interview using a structured questionnaire. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The prevalence of poor sleep quality (PSQI score five or more) was estimated and the associations with study variables were measured by crude and adjusted prevalence ratios using Poisson regression.

Results

participants were mostly women (50.9 %), with an average age of 43.3 years. The median total PSQI score was 4 (IQ = 3-7). The frequency of poor sleep quality was 32.7 % (95 % CI 30.7-34.4), higher in older adults (44.0 % vs 30.7 %; p<0.001) and women (40.0 % vs 25.2 %; p<0.001). Multivariate analysis showed that women (PR = 1.3; 95%CI 1.1- 1.5; p<0.001), former smokers (PR = 1.2; 95%CI 1.0-1.4; p = 0.014), current smokers (PR = 1.3; 95%CI 1.1-1.5; p = 0.006), depression (PR = 1.5; 95%CI 1.3-1.7; p<0.001), taking 5 or more medications (PR = 1.2; 95%CI 1.1-1.4; p = 0.001), self-perceived fair health (PR = 2.1; 95%CI 1.8-2.4; p<0.001) or poor/very poor health (PR = 2.6; 95%CI 2.1-3.1; p<0.001) were risk factors for poor sleep quality. Germanic culture (PR = 0.8; 95%CI 0.7-0.9; p<0.001), high school (PR = 0.8; 95%CI 0.6–1.0; p = 0.046) or elementary school (PR = 0.7; 95%CI 0.6-1.0; p = 0.025) or being at work (RP = 0.8; 95%CI 0.7-0.9; p = 0.002) were inversely associated with poor sleep quality.

Conclusions

Women, older adults and some clinical, social, cultural and behavioural conditions are associated with poor sleep quality.
目标分析巴西南部一个最初由德国人殖民的城市的参与者的睡眠质量以及相关的社会人口和生活方式因素。 方法对 2333 名年龄在 20 岁至 79 岁之间的人进行横断面人群研究。数据通过结构化问卷调查收集。睡眠质量采用匹兹堡睡眠质量指数(PSQI)问卷进行评估。我们估算了睡眠质量差(PSQI 得分为 5 分或 5 分以上)的患病率,并使用泊松回归法通过粗略患病率比和调整患病率比测量了睡眠质量差与研究变量之间的关联。PSQI 总分的中位数为 4(IQ = 3-7)。睡眠质量差的发生率为 32.7%(95% CI 30.7-34.4),老年人(44.0% vs 30.7%;p<0.001)和女性(40.0% vs 25.2%;p<0.001)的发生率更高。多变量分析显示,女性(PR = 1.3; 95%CI 1.1- 1.5; p<0.001)、曾经吸烟者(PR = 1.2; 95%CI 1.0-1.4; p = 0.014)、目前吸烟者(PR = 1.3; 95%CI 1.1-1.5; p = 0.006)、抑郁症患者(PR = 1.5; 95%CI 1.3-1.7; p<0.001)、服用 5 种或更多药物(PR = 1.2;95%CI 1.1-1.4;p = 0.001)、自我感觉健康状况一般(PR = 2.1;95%CI 1.8-2.4;p<0.001)或健康状况差/非常差(PR = 2.6;95%CI 2.1-3.1;p<0.001)是睡眠质量差的风险因素。日耳曼文化(PR = 0.8;95%CI 0.7-0.9;p<0.001)、高中(PR = 0.8;95%CI 0.6-1.0;p = 0.046)或小学(PR = 0.7;95%CI 0.6-1.0;p = 0.025)或正在工作(RP = 0.8;95%CI 0.结论女性、老年人以及一些临床、社会、文化和行为状况与睡眠质量差有关。
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引用次数: 0
Feasibility and acceptability of switching from a previous-generation to a new-generation mask for positive airway pressure therapy of sleep apnea using remote care 利用远程护理将用于睡眠呼吸暂停正压治疗的上一代面罩转换为新一代面罩的可行性和可接受性
Q1 Medicine Pub Date : 2024-10-11 DOI: 10.1016/j.sleepx.2024.100128
Xueling Zhu , Adam Benjafield , Ross Deas , Leslee Willes , Jeff Armitstead

Purpose

Mask selection could affect an individual's experience with positive airway pressure (PAP) treatment for obstructive sleep apnea, but there is very limited data on the impact of switching to a different mask once established on PAP therapy. This study investigated the patient's experience when switching from a previous-generation PAP mask to a new-generation mask via remote care.

Methods

A new-generation mask (AirFit F30i or AirFit N30i) was successfully fitted to 215 participants during video conferencing sessions. Participants completed online questionnaires on day 1, day 3, day 7, day 30 and day 90 after mask switch to collect subjective feedback and quality of life data; objective PAP device data were also downloaded.

Results

Residual apnea-hypopnea index showed statistically significant difference from baseline at day 30 (+0.2 ± 0.9/h [p = 0.026]) and day 90 (+0.2 ± 0.8/h [p = 0.006]), however unlikely to be clinically relevant. Average daily usage was significantly increased from baseline at day 30 (+0.2 ± 1.2 h/day [p = 0.010]) but not day 90 (+0.1 ± 1.0 h/day [p = 0.126]). Functional Outcomes of Sleep Questionnaire (FOSQ-10) score was significantly higher at day 90 (change from baseline to day 90: +0.48 ± 2.29 [p = 0.015]). Subjective ratings for comfort, seal, and usability of the new-generation mask were significantly better than the predefined acceptability level. Rates of PAP-related side effects were generally acceptable.

Conclusion

Remote management of mask change was associated with good outcomes in terms of objective device data and patient acceptability. This approach could be used to improve the overall therapy experience for individuals requiring a PAP therapy mask change for any reason.

Clinical trial registration

http://clinicaltrials.gov (NCT05262439).
目的 面罩的选择可能会影响阻塞性睡眠呼吸暂停患者接受气道正压(PAP)治疗的体验,但有关接受 PAP 治疗后更换不同面罩的影响的数据非常有限。本研究调查了患者通过远程护理从上一代气道正压面罩更换到新一代面罩时的体验。方法在视频会议期间为 215 名参与者成功安装了新一代面罩(AirFit F30i 或 AirFit N30i)。结果剩余呼吸暂停-低通气指数在第 30 天(+0.2 ± 0.9/h [p = 0.026])和第 90 天(+0.2 ± 0.8/h [p = 0.006])与基线相比有显著统计学差异,但与临床无关。在第 30 天,平均每天使用时间比基线明显增加(+0.2 ± 1.2 小时/天 [p = 0.010]),但第 90 天(+0.1 ± 1.0 小时/天 [p = 0.126])则没有增加。睡眠功能结果问卷(FOSQ-10)得分在第 90 天显著提高(从基线到第 90 天的变化:+0.48 ± 2.29 [p = 0.015])。对新一代面罩的舒适度、密封性和可用性的主观评价明显优于预定的可接受性水平。结论就客观设备数据和患者接受度而言,面罩更换的远程管理具有良好的效果。这种方法可用于改善因任何原因需要更换 PAP 治疗面罩的患者的整体治疗体验。临床试验注册http://clinicaltrials.gov (NCT05262439)。
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引用次数: 0
期刊
Sleep Medicine: X
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