衰老免疫学:炎症的诞生。

IF 8.4 2区 医学 Q1 ALLERGY Clinical Reviews in Allergy & Immunology Pub Date : 2023-04-01 DOI:10.1007/s12016-021-08899-6
T Fulop, A Larbi, G Pawelec, A Khalil, A A Cohen, K Hirokawa, J M Witkowski, C Franceschi
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引用次数: 92

摘要

炎症的概念是由Franceschi教授在2000年提出的。这是一个进化的,或者说是革命性的概念,免疫变化是对终身压力的反应。这一概念允许将终身促炎过程视为一种适应,最终可能导致有益或有害的后果。这种二分法受到遗传和环境的双重影响。取决于个体中哪种方式盛行,结果可能是健康长寿,也可能是与衰老相关的疾病带来的病理性衰老。炎症的概念也揭示了衰老的复杂性和系统性。因此,这种概念化为考虑与年龄相关的过程的复杂性开辟了道路,这意味着不仅要考虑过程,还要考虑所有反过程。它还开辟了在原有的基础上增加新概念的道路,从而更好地理解炎症和衰老本身的本质。最后,它显示了实现潜在的多模式干预的方式,包括采用整体方法来优化衰老过程,以实现健康长寿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Immunology of Aging: the Birth of Inflammaging.

The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress. This conceptualization permitted to consider the lifelong proinflammatory process as an adaptation which could eventually lead to either beneficial or detrimental consequences. This dichotomy is influenced by both the genetics and the environment. Depending on which way prevails in an individual, the outcome may be healthy longevity or pathological aging burdened with aging-related diseases. The concept of inflammaging has also revealed the complex, systemic nature of aging. Thus, this conceptualization opens the way to consider age-related processes in their complexity, meaning that not only the process but also all counter-processes should be considered. It has also opened the way to add new concepts to the original one, leading to better understanding of the nature of inflammaging and of aging itself. Finally, it showed the way towards potential multimodal interventions involving a holistic approach to optimize the aging process towards a healthy longevity.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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