Vladimir V Rafalskiy, Andrey Yu Zyubin, Ekaterina M Moiseeva, Galina S Kupriyanova, Ivan G Mershiev, Nadezhda O Kryukova, Igor I Kon, Ilya G Samusev, Yana D Belousova, Svetlana A Doktorova
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引用次数: 2
摘要
目的:开发测定药物浓度的新方法是当今的现实课题。本文对振动波谱法和核磁共振法在药代动力学研究中的应用进行了综述。本研究致力于利用振动波谱和1H核磁共振波谱测定药物浓度的可能性，以及利用这两组技术进行治疗药物监测。内容:本研究通过科学图书馆(Scopus, Web of Science Core Collection, Medline, GoogleScholar, eLIBRARY, PubMed)和参考文献进行。检索了2011年至2021年期间的俄语和英语，组合词:1H核磁共振(1H NMR)，振动光谱，表面增强拉曼光谱，药物浓度，治疗药物监测。这些方法具有许多优点，并且没有经典治疗药物监测(TDM)方法(高效液相色谱法和质谱法)的一些缺点。本文综述了利用表面增强拉曼散射(SERS)和1H核磁共振光谱(nmr)方法评估各种生物介质(血液、尿液)中药物浓度以及研究细胞内代谢和眼科药物代谢的可能性。1Н核磁共振光谱可以选择作为TDM方法，因为它可以分析各种药物的结构和识别代谢物。1Н基于核磁共振的代谢组学可以提供药物副作用的信息，预测治疗反应，并提供已知和新药物化合物作用机制的关键信息。总结与展望:SERS和1Н核磁共振波谱学具有很大的研究潜力和将其引入临床实践的可能性，包括用于评估药物的有效性和安全性。
Application of vibrational spectroscopy and nuclear magnetic resonance methods for drugs pharmacokinetics research.
Objectives: The development of new methods for determining the concentration of drugs is an actual topic today. The article contains a detailed review on vibrational spectroscopy and nuclear magnetic resonance methods using for pharmacokinetic research. This study is devoted to the possibility of using vibrational spectroscopy and 1H nuclear magnetic resonance spectroscopy to determine the concentration of drugs and the use of these groups of techniques for therapeutic drug monitoring.
Content: The study was conducted by using scientific libraries (Scopus, Web of Science Core Collection, Medline, GoogleScholar, eLIBRARY, PubMed) and reference literature. A search was conducted for the period from 2011 to 2021 in Russian and English, by combinations of words: 1H nuclear magnetic resonance (1H NMR), vibrational spectroscopy, Surface-Enhanced Raman spectroscopy, drug concentration, therapeutic drug monitoring. These methods have a number of advantages and are devoid of some of the disadvantages of classical therapeutic drug monitoring (TDM) methods - high performance liquid chromatography and mass spectrometry. This review considers the possibility of using the methods of surface-enhanced Raman scattering (SERS) and 1H NMR-spectroscopy to assess the concentration of drugs in various biological media (blood, urine), as well as to study intracellular metabolism and the metabolism of ophthalmic drugs. 1Н NMR-spectroscopy can be chosen as a TDM method, since it allows analyzing the structure and identifying metabolites of various drugs. 1Н NMR-based metabolomics can provide information on the side effects of drugs, predict response to treatment, and provide key information on the mechanisms of action of known and new drug compounds.
Summary and outlook: SERS and 1Н NMR-spectroscopy have great potential for further study and the possibility of introducing them into clinical practice, including for evaluating the efficacy and safety of drugs.
期刊介绍：
Drug Metabolism and Personalized Therapy (DMPT) is a peer-reviewed journal, and is abstracted/indexed in relevant major Abstracting Services. It provides up-to-date research articles, reviews and opinion papers in the wide field of drug metabolism research, covering established, new and potential drugs, environmentally toxic chemicals, the mechanisms by which drugs may interact with each other and with biological systems, and the pharmacological and toxicological consequences of these interactions and drug metabolism and excretion. Topics: drug metabolizing enzymes, pharmacogenetics and pharmacogenomics, biochemical pharmacology, molecular pathology, clinical pharmacology, pharmacokinetics and drug-drug interactions, immunopharmacology, neuropsychopharmacology.
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