探索具有生物活性的芦荟和树胶接枝共聚制备水凝胶创面敷料

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2023-11-02 DOI:10.1016/j.fhfh.2023.100168
Baljit Singh, Jasvir Singh, Vikrant Sharma, Ankita Kumari, Diwanshi Sharma
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引用次数: 0

摘要

考虑到碳水化合物研究的未来前景,本文探讨了生物活性多糖芦荟(AV)和木耳胶(SG)在开发网络水凝胶伤口敷料方面的潜力。多糖、AV凝胶的葡甘露聚糖和SG的葡萄糖醛酸-半乳糖醛酸均能促进伤口愈合。采用卡波醇接枝共聚的方法设计了头孢呋辛包封敷料。通过SEM、AFM、FTIR、C13 NMR、XRD、tg - dtg、DSC和溶胀研究对共聚物进行了表征。头孢呋辛的缓慢扩散机制为非菲克机制,药物释放为一级动力学模型。聚合物-生物膜相互作用表明黏附性质。在聚合物-血液相互作用过程中,血块形成减少,表明敷料具有生物相容性,而且敷料具有抗氧化性。多孔敷料具有氧气渗透性和微生物不渗透性。水凝胶敷料对铜绿假单胞菌具有抗菌活性。在水凝胶伤口敷料中加入头孢呋辛后,抗菌活性增强。总之,这些生化试验的结果、抗生素药物的缓释和AV-SG固有的伤口愈合潜力表明,水凝胶作为敷料可以更好地愈合伤口。
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Exploring bioactive aloe-vera and sterculia gum to develop hydrogel wound dressings by graft-copolymerization

Keeping in view the progressive future prospectus of carbohydrate research, herein, the potential of bioactive polysaccharides aloe vera (AV) and sterculia gum (SG) was explored to develop network hydrogel wound dressings. Both polysaccharides, acemannan of AV gel and glucuronic-galacturonic acid of SG accelerate wound healing process. The antibiotic drug cefuroxime encapsulated dressings were designed by graft-copolymerization with carbopol. The copolymers were characterized by SEM, AFM, FTIR, C13 NMR, XRD, TGA-DTG, DSC and swelling studies. The slow diffusion of cefuroxime drug exhibited non-Fickian mechanism and release of drug was occurred with a first order kinetic model. Polymer-bio membrane interactions indicated mucoadhesion nature. The clot formation was reduced during polymer-blood interactions indicated bio-compatible nature of the dressings moreover dressings were found antioxidant in nature. The porous dressings were O2 permeable and microbial impermeable. The hydrogel dressings revealed antimicrobial activity against P. aeruginosa. Degree of antimicrobial activity enhanced in case of hydrogel wound dressings loaded with cefuroxime. Overall, the results of these biochemical assays, sustained release of antibiotic drug and inherent wound healing potential of AV-SG indicated the use of hydrogels as dressing materials for better wound healing.

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审稿时长
61 days
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