探索具有生物活性的芦荟和树胶接枝共聚制备水凝胶创面敷料

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2023-11-02 DOI:10.1016/j.fhfh.2023.100168
Baljit Singh, Jasvir Singh, Vikrant Sharma, Ankita Kumari, Diwanshi Sharma
{"title":"探索具有生物活性的芦荟和树胶接枝共聚制备水凝胶创面敷料","authors":"Baljit Singh,&nbsp;Jasvir Singh,&nbsp;Vikrant Sharma,&nbsp;Ankita Kumari,&nbsp;Diwanshi Sharma","doi":"10.1016/j.fhfh.2023.100168","DOIUrl":null,"url":null,"abstract":"<div><p>Keeping in view the progressive future prospectus of carbohydrate research, herein, the potential of bioactive polysaccharides aloe vera (AV) and sterculia gum (SG) was explored to develop network hydrogel wound dressings. Both polysaccharides, acemannan of AV gel and glucuronic-galacturonic acid of SG accelerate wound healing process. The antibiotic drug cefuroxime encapsulated dressings were designed by graft-copolymerization with carbopol. The copolymers were characterized by SEM, AFM, FTIR, C<sup>13</sup> NMR, XRD, TGA-DTG, DSC and swelling studies. The slow diffusion of cefuroxime drug exhibited non-Fickian mechanism and release of drug was occurred with a first order kinetic model. Polymer-bio membrane interactions indicated mucoadhesion nature. The clot formation was reduced during polymer-blood interactions indicated bio-compatible nature of the dressings moreover dressings were found antioxidant in nature. The porous dressings were O<sub>2</sub> permeable and microbial impermeable. The hydrogel dressings revealed antimicrobial activity against <em>P. aeruginosa.</em> Degree of antimicrobial activity enhanced in case of hydrogel wound dressings loaded with cefuroxime. Overall, the results of these biochemical assays, sustained release of antibiotic drug and inherent wound healing potential of AV-SG indicated the use of hydrogels as dressing materials for better wound healing.</p></div>","PeriodicalId":12385,"journal":{"name":"Food Hydrocolloids for Health","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667025923000523/pdfft?md5=6a2b0b0190b2a1123a39863f448ca250&pid=1-s2.0-S2667025923000523-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Exploring bioactive aloe-vera and sterculia gum to develop hydrogel wound dressings by graft-copolymerization\",\"authors\":\"Baljit Singh,&nbsp;Jasvir Singh,&nbsp;Vikrant Sharma,&nbsp;Ankita Kumari,&nbsp;Diwanshi Sharma\",\"doi\":\"10.1016/j.fhfh.2023.100168\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Keeping in view the progressive future prospectus of carbohydrate research, herein, the potential of bioactive polysaccharides aloe vera (AV) and sterculia gum (SG) was explored to develop network hydrogel wound dressings. Both polysaccharides, acemannan of AV gel and glucuronic-galacturonic acid of SG accelerate wound healing process. The antibiotic drug cefuroxime encapsulated dressings were designed by graft-copolymerization with carbopol. The copolymers were characterized by SEM, AFM, FTIR, C<sup>13</sup> NMR, XRD, TGA-DTG, DSC and swelling studies. The slow diffusion of cefuroxime drug exhibited non-Fickian mechanism and release of drug was occurred with a first order kinetic model. Polymer-bio membrane interactions indicated mucoadhesion nature. The clot formation was reduced during polymer-blood interactions indicated bio-compatible nature of the dressings moreover dressings were found antioxidant in nature. The porous dressings were O<sub>2</sub> permeable and microbial impermeable. The hydrogel dressings revealed antimicrobial activity against <em>P. aeruginosa.</em> Degree of antimicrobial activity enhanced in case of hydrogel wound dressings loaded with cefuroxime. Overall, the results of these biochemical assays, sustained release of antibiotic drug and inherent wound healing potential of AV-SG indicated the use of hydrogels as dressing materials for better wound healing.</p></div>\",\"PeriodicalId\":12385,\"journal\":{\"name\":\"Food Hydrocolloids for Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2023-11-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667025923000523/pdfft?md5=6a2b0b0190b2a1123a39863f448ca250&pid=1-s2.0-S2667025923000523-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Hydrocolloids for Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667025923000523\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Hydrocolloids for Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667025923000523","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0

摘要

考虑到碳水化合物研究的未来前景,本文探讨了生物活性多糖芦荟(AV)和木耳胶(SG)在开发网络水凝胶伤口敷料方面的潜力。多糖、AV凝胶的葡甘露聚糖和SG的葡萄糖醛酸-半乳糖醛酸均能促进伤口愈合。采用卡波醇接枝共聚的方法设计了头孢呋辛包封敷料。通过SEM、AFM、FTIR、C13 NMR、XRD、tg - dtg、DSC和溶胀研究对共聚物进行了表征。头孢呋辛的缓慢扩散机制为非菲克机制,药物释放为一级动力学模型。聚合物-生物膜相互作用表明黏附性质。在聚合物-血液相互作用过程中,血块形成减少,表明敷料具有生物相容性,而且敷料具有抗氧化性。多孔敷料具有氧气渗透性和微生物不渗透性。水凝胶敷料对铜绿假单胞菌具有抗菌活性。在水凝胶伤口敷料中加入头孢呋辛后,抗菌活性增强。总之,这些生化试验的结果、抗生素药物的缓释和AV-SG固有的伤口愈合潜力表明,水凝胶作为敷料可以更好地愈合伤口。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Exploring bioactive aloe-vera and sterculia gum to develop hydrogel wound dressings by graft-copolymerization

Keeping in view the progressive future prospectus of carbohydrate research, herein, the potential of bioactive polysaccharides aloe vera (AV) and sterculia gum (SG) was explored to develop network hydrogel wound dressings. Both polysaccharides, acemannan of AV gel and glucuronic-galacturonic acid of SG accelerate wound healing process. The antibiotic drug cefuroxime encapsulated dressings were designed by graft-copolymerization with carbopol. The copolymers were characterized by SEM, AFM, FTIR, C13 NMR, XRD, TGA-DTG, DSC and swelling studies. The slow diffusion of cefuroxime drug exhibited non-Fickian mechanism and release of drug was occurred with a first order kinetic model. Polymer-bio membrane interactions indicated mucoadhesion nature. The clot formation was reduced during polymer-blood interactions indicated bio-compatible nature of the dressings moreover dressings were found antioxidant in nature. The porous dressings were O2 permeable and microbial impermeable. The hydrogel dressings revealed antimicrobial activity against P. aeruginosa. Degree of antimicrobial activity enhanced in case of hydrogel wound dressings loaded with cefuroxime. Overall, the results of these biochemical assays, sustained release of antibiotic drug and inherent wound healing potential of AV-SG indicated the use of hydrogels as dressing materials for better wound healing.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.50
自引率
0.00%
发文量
0
审稿时长
61 days
期刊最新文献
Green synthesis of silver nanoparticles from mulberry leaf through hot melt extrusion: Enhanced antioxidant, antibacterial, anti-inflammatory, antidiabetic, and anticancer properties Silkworm pupae protein-based film incorporated with Catharanthus roseus leaf extract-based nanoparticles enhanced the lipid stability and microbial quality of cheddar cheese Re-processing of pharmaceutical herb residues using isolated probiotics from plant sources and their beneficial effects on diarrhea Investigating next-generation edible packaging: Protein-based films and coatings for delivering active compounds Recent advances on antimicrobial peptide and polysaccharide hydrogels
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1