膜融合促进药物跨膜传递

Q1 Engineering Smart Materials in Medicine Pub Date : 2022-01-01 DOI:10.1016/j.smaim.2022.01.009

Xing Gao, En Ren, Gang Liu

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引用次数: 3

摘要

得益于融合元素(多肽或蛋白质)的锚定，几种生物膜囊泡或合成脂质体通过模拟病毒的行为与靶细胞膜融合。当这一过程发生时，被封装的货物可以与膜成分(蛋白质受体、通道蛋白、化学受体、抗体)转移一起直接释放到细胞质中，这一过程有助于细胞/分子诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Membrane fusion boosting drug transmembrane delivery

Benefiting from fusion element (peptides or proteins) anchoring, several biological membrane vesicles or synthetic liposomes have great potency to fuse with the target cell membrane via virus-mimetic behavior. When this process happens, the encapsulated cargos can be released directly into the cytoplasm together with membrane component (protein receptor, channel proteins, chemical receptors, antibodies) transfer, a process that facilitates cellular/molecular diagnosis and therapy.

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