高剂量与低剂量顺铂对头颈部鳞状细胞癌患者吞咽功能的影响。

IF 1.8 4区医学 Q3 ONCOLOGY Cancer Investigation Pub Date : 2023-12-01 Epub Date: 2024-01-02 DOI:10.1080/07357907.2023.2283452

Amber Veldman, Annika van Oosbree, Madisyn Braun, Aarabhi Gurumoorthy, William C Spanos, Steven Powell

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引用次数: 0

摘要

以顺铂为基础的治疗是晚期头颈部鳞状细胞癌(HNSCC)的标准治疗。治疗方案包括3周高剂量单次顺铂治疗或6-7周低剂量单次顺铂治疗，同时进行放射治疗。顺铂剂量对吞咽功能的影响有待进一步研究。回顾性研究了237例在单一中心接受治疗的HNSCC患者。胃造口管依赖是主要终点。次要终点包括体重变化、食管狭窄和淋巴水肿。主要/次要结局无统计学意义;高剂量组耳毒性和肾毒性明显增高。这些发现增加了对顺铂基于剂量的功能结果的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Assessment of Swallowing Function in Patients with Head and Neck Squamous Cell Carcinoma in High vs. Low Dose Cisplatin.

Cisplatin-based therapies are standard-of-care for advanced-stage head and neck squamous cell carcinoma (HNSCC). Treatment regimens include 3 weeks of high-dose bolus cisplatin or 6-7 weeks of low-dose weekly cisplatin, both with concurrent radiation. The effects of cisplatin dosage on swallowing function warrant further study. A 237-patient cohort treated for HNSCC at a single center were studied retrospectively. Gastrostomy tube dependence served as the primary endpoint. Secondary endpoints included weight changes, esophageal stricture, and lymphedema. The primary/secondary outcomes were not statistically significant; however, ototoxicity and renal toxicity were significantly higher in the high-dose group. These findings add insight into cisplatin dose-based functional outcomes.

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.