{"title":"治疗副作用影响活动性乳腺癌幸存者运动微血管氧合反应:一项初步研究","authors":"Trent E. Cayot, Brooklyn Herbert, Riggs J. Klika","doi":"10.1111/cpf.12796","DOIUrl":null,"url":null,"abstract":"<p>Cancer treatment is associated with cardiovascular toxicity, skeletal muscle dysfunction and interruptions in mitochondrial respiration. Microvascular oxygenation responses, measured via near-infrared spectroscopy (NIRS), at peak exercise intensity has previously been associated with aerobic capacity. Specifically, the greater magnitude of microvascular deoxygenation observed at peak exercise intensity has been associated with higher aerobic capacity. Therefore, a pilot study investigated if diagnosis side (uninvolved side, treatment side) and/or exercise side (paddle side, non-paddle side) affected microvascular oxygenation responses at peak intensity during paddle exercise. Thirty-three breast cancer survivors (age = 57 ± 9 years, height = 1.64 ± 0.05 m, weight = 76.5 ± 15.6 kg, 7 ± 7 years since treatment) who also competed as dragon boat racers performed a unilateral (paddle), discontinuous graded exercise test (2-min exercise, 1-min rest) on a rowing ergometer to volitional fatigue. Tissue oxygenation saturation (StO<sub>2DIFF</sub>) and total haemoglobin concentration (total[heme]<sub>DIFF</sub>) responses at peak exercise intensity were measured bilaterally from the posterior deltoids using NIRS. Two-way analysis of variance determined if diagnosis side and/or exercise side effected StO<sub>2DIFF</sub> or total[heme]<sub>DIFF</sub>. Diagnosis side elicited a moderate effect (effect size = 0.66) on StO<sub>2DIFF</sub>, as the treatment side deoxygenated less (−6.0 ± 14.7 ∆BSL) compared to the uninvolved side (−16.9 ± 16.9 ∆BSL) at peak exercise intensity. No other significant main effects or interactions were observed for StO<sub>2DIFF</sub> or total[heme]<sub>DIFF</sub>. The pilot findings suggest that the ability of the exercising muscle to use oxygen for the purpose of mitochondrial oxidative respiration may be impaired on the treatment side.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Treatment side affects exercising microvascular oxygenation response in active breast cancer survivors: A pilot study\",\"authors\":\"Trent E. Cayot, Brooklyn Herbert, Riggs J. Klika\",\"doi\":\"10.1111/cpf.12796\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Cancer treatment is associated with cardiovascular toxicity, skeletal muscle dysfunction and interruptions in mitochondrial respiration. Microvascular oxygenation responses, measured via near-infrared spectroscopy (NIRS), at peak exercise intensity has previously been associated with aerobic capacity. Specifically, the greater magnitude of microvascular deoxygenation observed at peak exercise intensity has been associated with higher aerobic capacity. Therefore, a pilot study investigated if diagnosis side (uninvolved side, treatment side) and/or exercise side (paddle side, non-paddle side) affected microvascular oxygenation responses at peak intensity during paddle exercise. Thirty-three breast cancer survivors (age = 57 ± 9 years, height = 1.64 ± 0.05 m, weight = 76.5 ± 15.6 kg, 7 ± 7 years since treatment) who also competed as dragon boat racers performed a unilateral (paddle), discontinuous graded exercise test (2-min exercise, 1-min rest) on a rowing ergometer to volitional fatigue. Tissue oxygenation saturation (StO<sub>2DIFF</sub>) and total haemoglobin concentration (total[heme]<sub>DIFF</sub>) responses at peak exercise intensity were measured bilaterally from the posterior deltoids using NIRS. Two-way analysis of variance determined if diagnosis side and/or exercise side effected StO<sub>2DIFF</sub> or total[heme]<sub>DIFF</sub>. Diagnosis side elicited a moderate effect (effect size = 0.66) on StO<sub>2DIFF</sub>, as the treatment side deoxygenated less (−6.0 ± 14.7 ∆BSL) compared to the uninvolved side (−16.9 ± 16.9 ∆BSL) at peak exercise intensity. No other significant main effects or interactions were observed for StO<sub>2DIFF</sub> or total[heme]<sub>DIFF</sub>. The pilot findings suggest that the ability of the exercising muscle to use oxygen for the purpose of mitochondrial oxidative respiration may be impaired on the treatment side.</p>\",\"PeriodicalId\":10504,\"journal\":{\"name\":\"Clinical Physiology and Functional Imaging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2022-11-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Physiology and Functional Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cpf.12796\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Physiology and Functional Imaging","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cpf.12796","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Treatment side affects exercising microvascular oxygenation response in active breast cancer survivors: A pilot study
Cancer treatment is associated with cardiovascular toxicity, skeletal muscle dysfunction and interruptions in mitochondrial respiration. Microvascular oxygenation responses, measured via near-infrared spectroscopy (NIRS), at peak exercise intensity has previously been associated with aerobic capacity. Specifically, the greater magnitude of microvascular deoxygenation observed at peak exercise intensity has been associated with higher aerobic capacity. Therefore, a pilot study investigated if diagnosis side (uninvolved side, treatment side) and/or exercise side (paddle side, non-paddle side) affected microvascular oxygenation responses at peak intensity during paddle exercise. Thirty-three breast cancer survivors (age = 57 ± 9 years, height = 1.64 ± 0.05 m, weight = 76.5 ± 15.6 kg, 7 ± 7 years since treatment) who also competed as dragon boat racers performed a unilateral (paddle), discontinuous graded exercise test (2-min exercise, 1-min rest) on a rowing ergometer to volitional fatigue. Tissue oxygenation saturation (StO2DIFF) and total haemoglobin concentration (total[heme]DIFF) responses at peak exercise intensity were measured bilaterally from the posterior deltoids using NIRS. Two-way analysis of variance determined if diagnosis side and/or exercise side effected StO2DIFF or total[heme]DIFF. Diagnosis side elicited a moderate effect (effect size = 0.66) on StO2DIFF, as the treatment side deoxygenated less (−6.0 ± 14.7 ∆BSL) compared to the uninvolved side (−16.9 ± 16.9 ∆BSL) at peak exercise intensity. No other significant main effects or interactions were observed for StO2DIFF or total[heme]DIFF. The pilot findings suggest that the ability of the exercising muscle to use oxygen for the purpose of mitochondrial oxidative respiration may be impaired on the treatment side.
期刊介绍:
Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest.
Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.