线粒体凋亡信号参与肌发生和骨骼肌萎缩过程中的重塑

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-07-15 DOI:10.1016/j.semcdb.2022.01.011
Fasih Ahmad Rahman, Joe Quadrilatero
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引用次数: 5

摘要

线粒体在细胞凋亡信号传导中起着重要作用。除了在消除功能失调细胞方面的作用外,线粒体凋亡信号传导是肌源性分化和骨骼肌萎缩的关键组成部分。例如,半胱氨酸天冬氨酸蛋白酶(caspases;CASP)的激活可以通过裂解蛋白激酶、转录因子和细胞骨架蛋白来帮助肌源性分化的初始重塑阶段。需要精确调节这些信号,以防止过度的细胞分解和随后的细胞死亡。在骨骼肌萎缩期间,CASP和线粒体衍生的核酸酶的激活参与了肌细胞核的断裂、肌细胞核的潜在损失以及骨骼肌内收缩结构的断裂。B细胞白血病/淋巴瘤2(BCL2)蛋白家族通过控制线粒体凋亡信号的起始步骤,在调节肌发生和骨骼肌萎缩中发挥重要作用。这篇综述讨论了线粒体凋亡信号在肌源性分化和骨骼肌病理状态(包括衰老、废用和肌营养不良)过程中骨骼肌重塑中的作用。
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Mitochondrial Apoptotic Signaling Involvement in Remodeling During Myogenesis and Skeletal Muscle Atrophy

Mitochondria play a major role in apoptotic signaling. In addition to its role in eliminating dysfunctional cells, mitochondrial apoptotic signaling is implicated as a key component of myogenic differentiation and skeletal muscle atrophy. For example, the activation of cysteine-aspartic proteases (caspases; CASP's) can aid in the initial remodeling stages of myogenic differentiation by cleaving protein kinases, transcription factors, and cytoskeletal proteins. Precise regulation of these signals is needed to prevent excessive cell disassemble and subsequent cell death. During skeletal muscle atrophy, the activation of CASP's and mitochondrial derived nucleases participate in myonuclear fragmentation, a potential loss of myonuclei, and cleavage of contractile structures within skeletal muscle. The B cell leukemia/lymphoma 2 (BCL2) family of proteins play a significant role in regulating myogenesis and skeletal muscle atrophy by governing the initiating steps of mitochondrial apoptotic signaling. This review discusses the role of mitochondrial apoptotic signaling in skeletal muscle remodeling during myogenic differentiation and skeletal muscle pathological states, including aging, disuse, and muscular dystrophy.

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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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