宫颈细胞学辅助技术综述。

IF 1.6 4区医学 Q3 PATHOLOGY Acta Cytologica Pub Date : 2023-01-01 DOI:10.1159/000528931

Andrea D Olivas, Julieta E Barroeta, Ricardo R Lastra

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引用次数: 2

摘要

背景:人乳头瘤病毒(hr-HPV)高危血清型与宫颈癌之间的关系已得到证实。摘要:为了提高宫颈细胞学检查的敏感性，hr-HPV检测已迅速成为常规宫颈癌筛查的一部分，无论是与细胞学检查结合还是作为主要检查。在这篇综述中，我们讨论了hr-HPV检测的总体效用和策略，以及hr-HPV阳性女性的潜在分类策略的优点和局限性，包括HPV基因分型，p16/Ki-67双染色和甲基化检测。关键信息:hr-HPV检测被讨论为初级筛查，HPV基因分型，p16/Ki-67双染色和甲基化检测被讨论为细胞学辅助技术，在hr-HPV阳性妇女接受宫颈癌筛查。

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Overview of Ancillary Techniques in Cervical Cytology.

Background: The association between high-risk serotypes of human papillomavirus (hr-HPV) and cervical cancer is well-established.

Summary: In order to improve the sensitivity of cervical cytology testing, hr-HPV testing has rapidly become part of routine cervical cancer screening, either in conjunction with cytology or as primary testing. In this review, we discuss the overall utility and strategies of hr-HPV testing, as well as the advantages and limitations of potential triage strategies for hr-HPV-positive women, including HPV genotyping, p16/Ki-67 dual staining, and methylation assays.

Key message: hr-HPV testing is discussed as primary screening and HPV genotyping, p16/Ki-67 dual staining, and methylation assays are discussed as ancillary techniques to cytology in the triage of hr-HPV-positive women undergoing cervical cancer screening.

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来源期刊

Acta Cytologica 生物-病理学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

4-8 weeks

期刊介绍： With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.