间充质间质细胞治疗慢性肺部疾病:实验和临床证据。

IF 2.9 3区 医学 Q2 RESPIRATORY SYSTEM Expert Review of Respiratory Medicine Pub Date : 2023-03-01 DOI:10.1080/17476348.2023.2196015
Monique Martins Melo, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco
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引用次数: 1

摘要

细胞疗法已成为慢性肺部疾病的另一种选择,在世界范围内具有最高的发病率和死亡率。涵盖领域:本文综述了间充质间质细胞(MSCs)的定义、性质、作用机制,以及使用细胞疗法治疗慢性肺部疾病(如哮喘、慢性阻塞性肺疾病、特发性肺纤维化、肺动脉高压和矽肺)的临床前和临床研究。还介绍了正在进行的临床试验。专家意见:实验证据表明,MSCs具有免疫调节和再生特性,可以挽救受损的肺功能和组织结构。它们的有益作用主要与它们通过可溶性介质和细胞外囊泡的分泌,甚至通过细胞器(如线粒体)的转移,与靶细胞进行通信的能力有关。msc衍生的条件培养基、细胞外囊泡和线粒体在特定情况下可诱导有益作用。与实验结果相比,临床试验的初步结果比较温和,因此鼓励研究人员从床边回到实验室,开发能够增强间充质干细胞作用的新策略。
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Mesenchymal stromal cell therapy for chronic lung diseases: experimental and clinical evidence.

Introduction: Cell therapy has emerged as an alternative option for chronic lung diseases with the highest rates of morbidity and mortality rates worldwide.

Areas covered: This review addresses the definition of mesenchymal stromal cells (MSCs), their properties, mechanisms of action, as well as preclinical and clinical studies that have used cell therapy in chronic lung diseases such as asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, and silicosis. Ongoing clinical trials are also presented.

Expert opinion: Experimental evidence has shown that MSCs have immunomodulatory and regenerative properties that could rescue impaired lung function and histoarchitecture. Their beneficial effects have been mainly associated with their ability to communicate with target cells through the secretion of soluble mediators and extracellular vesicles or even through transfer of organelles (e.g. mitochondria). MSC-derived conditioned medium, extracellular vesicles and mitochondria induce beneficial effects in selected scenarios. The initial results in clinical trials were modest compared with the experimental results, therefore researchers were encouraged to move from bedside back to bench to develop new strategies able to potentiate the effects of MSCs.

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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
90
期刊介绍: Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity
期刊最新文献
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