好与坏:人类乳头瘤病毒对宿主DNA损伤反应的调节。

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2023-09-29 Epub Date: 2023-04-11 DOI:10.1146/annurev-virology-111821-103452
Caleb J Studstill, Cary A Moody
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引用次数: 0

摘要

高危型人乳头瘤病毒(HPV)与几种人类癌症有关。HPV是一种小型DNA病毒,依靠宿主细胞机制进行病毒复制。HPV的生命周期发生在复层上皮中,复层上皮由不同的细胞状态组成,包括在细胞周期中不再活跃的终末分化细胞。HPV已经进化出通过劫持和调节细胞途径(包括DNA损伤反应(DDR))在复层上皮中持续和复制的机制。HPV激活并利用DDR途径促进病毒复制,从而增加宿主细胞对基因组不稳定和致癌的易感性。在这里,我们回顾了我们对高风险HPV在病毒生命周期中调节宿主细胞DDR的理解的最新进展,并讨论了调节DDR途径的潜在细胞后果。
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For Better or Worse: Modulation of the Host DNA Damage Response by Human Papillomavirus.

High-risk human papillomaviruses (HPVs) are associated with several human cancers. HPVs are small, DNA viruses that rely on host cell machinery for viral replication. The HPV life cycle takes place in the stratified epithelium, which is composed of different cell states, including terminally differentiating cells that are no longer active in the cell cycle. HPVs have evolved mechanisms to persist and replicate in the stratified epithelium by hijacking and modulating cellular pathways, including the DNA damage response (DDR). HPVs activate and exploit DDR pathways to promote viral replication, which in turn increases the susceptibility of the host cell to genomic instability and carcinogenesis. Here, we review recent advances in our understanding of the regulation of the host cell DDR by high-risk HPVs during the viral life cycle and discuss the potential cellular consequences of modulating DDR pathways.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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