P物质和神经激肽-1受体在膀胱癌中的预后意义。

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Reports of Biochemistry and Molecular Biology Pub Date : 2022-10-01 DOI:10.52547/rbmb.11.3.411
Elnaz Zahiri, Hamidreza Ghorbani, Ali Moradi, Hassan Mehrad-Majd, Fariba Mohammadi, Noorieh Sharifi Sistani, Seyed Isaac Hashemy
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引用次数: 0

摘要

背景:膀胱癌是最常见的泌尿生殖系统肿瘤之一,死亡率很高。寻找可靠的肿瘤标志物和潜在的药物靶点可以改善早期诊断、预后和更有效的治疗方案。先前的研究报道了P物质(SP)/神经激肽-1受体(NK-1R)系统在癌症中的作用。SP和NK-1R在膀胱肿瘤中的潜在预后作用和相互作用尚不清楚。方法:采用ELISA法对22例原发性膀胱癌患者和22例健康对照者进行血清SP水平检测。通过免疫组化评价NK-1R在肿瘤及其邻近正常组织中的组织分布。结果:膀胱癌患者血清SP水平高于健康组(p< 0.001),并与NK-1R染色强度(p< 0.001)、染色细胞百分比(p< 0.001)、NK-1R组织分布有显著相关性。此外,NK-1R在肿瘤样本中的免疫反应性显著升高,但与肿瘤特征无关。然而,SP和NK-1R水平与肿瘤大小(p= 0.33)、肿瘤分期(p= 0.29)、分级(p= 0.93)、NK-1R染色强度(p= 0.53)和染色细胞百分比(p= 0.32)等临床特征无显著相关性。讨论:根据我们的研究结果,尽管SP和NK-1R与膀胱癌的临床特征之间缺乏相关性,但它们在膀胱癌患者的血清水平较高。SP和NK-1R在膀胱癌中的潜在预后作用有待进一步研究证实。
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Prognostic Significance of Substance P and Neurokinin-1 Receptor in Bladder Cancer.

Background: Bladder cancer is one of the most common genitourinary cancers with significant mortality. Finding reliable tumor markers and potential drug targets can improve early diagnosis, prognosis, and more effective therapeutic protocols. Previous studies have reported the involvement of the substance P (SP)/neurokinin-1 receptor (NK-1R) system in cancers. The potential prognostic role and the interaction of SP and NK-1R in bladder tumor are yet to be elucidated.

Methods: Serum samples from 22 primarily diagnosed patients with bladder cancer as well as 22 healthy controls were examined for SP level using ELISA method. Tissue distribution of NK-1R in tumor samples and their adjacent normal tissues was evaluated through immunohistochemistry.

Results: Serum SP levels in patients with bladder cancer were higher than the healthy group (p< 0.001) and had a significant correlation with NK-1R staining intensity (p< 0.001), percentage of stained cells (p< 0.001), and NK-1R tissue distribution. Also, the immunoreactivity of NK-1R in cancer samples increased significantly without correlation with tumor characteristics. However, no significant association was found between SP and NK-1R levels with clinical characteristics including tumor size (p= 0.33), tumor stage (p= 0.29), grade (p= 0.93), NK-1R staining intensity (p= 0.53), and percentage of stained cells (p= 0.32).

Discussion: According to our findings, despite the lack of association between SP and NK-1R with clinical characteristics of bladder cancer, their serum levels were higher in patients with bladder cancer. Further studies are needed to confirm the potential prognostic role of SP and NK-1R in bladder cancer.

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来源期刊
Reports of Biochemistry and Molecular Biology
Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
2.80
自引率
23.50%
发文量
60
审稿时长
10 weeks
期刊介绍: The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.
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