两种预测模型在应用重组生长激素预测青春期前儿童生长的临床比较

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2023-02-01 DOI:10.1016/j.ghir.2023.101523
Helena-Jamin Ly , Anders Lindberg , Hans Fors , Jovanna Dahlgren
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引用次数: 0

摘要

目的计算儿童对重组生长激素(GH)的生长反应的预测模型已被证明是决定谁应该开始治疗的有用工具,因为识别GH缺乏可能是一个挑战。本研究的目的是比较两种预测模型;更容易获得的KIGS(辉瑞国际生长研究)预测模型和先前已被临床验证的哥德堡模型。设计所有在哥德堡西尔维亚女王儿童医院接受GH治疗13年的青春期前患者都是该研究的候选者。如果发现疑似综合征、恶性疾病、慢性病或治疗依从性差,则将儿童排除在外。KIGS模型和哥德堡模型用于预测。数据来自医学图表,从出生到治疗第一年结束。将预测的身高结果与观察结果进行比较。结果本研究包括123名青春期前儿童(76名男性)。治疗开始时的平均年龄和标准差(SD)为5.7(1.8)岁。哥德堡和KIGS模型预测的生长与第一年观察到的生长反应之间进行了相关性分析,显示出分别为r=0.990和r=0.991的强相关性,哥德堡模型的学生残差为0.10(0.81),KIGS模型的学生化残差为0.03(0.96)。结论我们发现哥德堡模型和KIGS模型在应用于我们的临床队列时是等效的。这两种模型都非常精确,因此鼓励根据诊所的可访问性使用其中一种。
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Comparison of two prediction models in a clinical setting to predict growth in prepubertal children on recombinant growth hormone

Objective

Prediction models that calculate the growth response in children on recombinant growth hormone (GH) have shown to be helpful tools in deciding who should start treatment, as identifying GH deficiency can be a challenge. The aim of the study is to compare two prediction models; the KIGS (Pfizer International Growth Study) prediction models which are more accessible and the Gothenburg model which has previously been clinically validated.

Design

All prepubertal patients who commenced GH treatment at Queen Silvia Children's Hospital in Gothenburg during a 13-year-period were candidates for the study. Children were excluded if suspected syndrome, malignant disease, chronic disease, or poor adherence to treatment were found. The KIGS model and the Gothenburg model were used to make predictions. Data was obtained from medical charts for the period from birth to the end of the first year of treatment. The predicted height outcome was compared against observed.

Results

The study included 123 prepubertal children (76 males). The average age at treatment start and standard deviation (SD) was 5.7 (1.8) years. Correlation analyses were performed between predicted growth by both the Gothenburg and KIGS models versus the first year observed growth response showing strong correlations of r = 0.990 and r = 0.991 respectively with studentized residuals of 0.10 (0.81) for the Gothenburg model and 0.03 (0.96) for the KIGS model.

Conclusion

We found that both the Gothenburg model and the KIGS model are equivalent when applying to our clinical cohort. Both models are very precise, hence it is encouraged to use either based on accessibility for the clinic.

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来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
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