农药暴露与阿尔茨海默病:一项病例对照研究

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY Current Alzheimer research Pub Date : 2023-01-01 DOI:10.2174/1567205020666230206142738
Zohreh Kiani, Gholamreza Asadikaram, Sanaz Faramarz, Fouzieh Salimi, Hosseinali Ebrahimi
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引用次数: 0

摘要

目的:探讨阿尔茨海默病(AD)患者血清中有机氯农药(OCPs)的水平。方法:63例AD患者和50例健康人参与,检测部分OCPs衍生物(包括;测定α-HCH、β-HCH、γ-HCH、2,4- ddt、4,4- ddt、2,4- dde和4,4- dde)、总抗氧化能力(TAC)、蛋白羰基(PC)、丙二醛(MDA)、一氧化氮(NO)以及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)、对氧氧化酶1(PON1)和乙酰胆碱酯酶(AChE)的活性。结果:AD患者OCP的平均水平明显高于对照组。但患者TAC、PC、MDA平均水平及SOD、GPx、PON1、AChE活性均显著低于对照组。AD患者2,4- dde与MDA、γ-HCH与PC呈显著正相关。这些发现表明,农药暴露与阿尔茨海默病的风险增加有关。此外,与健康个体相比,AD患者的氧化应激标记物的平均水平显著降低,这可能是农药暴露的结果。结论:农药通过诱导氧化应激等多种机制,至少在一定程度上促进了AD的发展。
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Pesticide Exposure and Alzheimer's Disease: A Case-control Study.

Aim / Objective: This study aimed to investigate the levels of organochlorine pesticides (OCPs) in the serum of Alzheimer's disease (AD) patients.

Methods: 63 AD patients and 50 healthy individuals participated, and the levels of some OCPs derivatives (including; α-HCH, β-HCH, γ-HCH, 2,4-DDT, 4,4-DDT, 2,4-DDE, and 4,4-DDE), total antioxidant capacity (TAC), protein carbonyl (PC), malondialdehyde (MDA), Nitric oxide (NO) along with the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), paraoxonase 1(PON1), and acetylcholinesterase (AChE) were measured.

Results: The mean OCP level of OCPs in AD patients was significantly higher than in the control group. However, the patients' mean levels of TAC, PC, MDA and activity of SOD, GPx, PON1 and AChE were significantly lower than controls. A significant positive correlation was also observed between 2,4-DDE and MDA and between γ-HCH and PC in AD patients. These findings showed that pesticide exposure is associated with an increased risk of AD. Furthermore, the mean levels of oxidative stress markers, which may result from pesticide exposure, were significantly lower in AD patients compared to healthy individuals.

Conclusion: Therefore, it may conclude that pesticides, at least in part, contribute to AD development through several mechanisms, including the induction of oxidative stress.

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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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