{"title":"瘦素在哮喘中的预测和预后价值。","authors":"Juan Wang, Ruochen Zhu, Wenjing Shi, Song Mao","doi":"10.1038/s41533-023-00332-z","DOIUrl":null,"url":null,"abstract":"<p><p>Asthma is closely associated with inflammation. We evaluated the predictive and prognostic value of leptin status in asthma. We searched the electronic databases for articles that determined the leptin level in asthma cases through May 2020. We compared the differences of leptin level between asthma and non-asthma controls, as well as between severe and mild asthma cases. We also investigated the impact of age and gender on these differences by using meta-regression analysis. 59 studies were included in our pooled analysis. Asthma cases demonstrated significantly higher leptin level than that in non-asthma controls among overall populations (SMD:1.061, 95% CI: 0.784-1.338, p < 10<sup>-4</sup>), Caucasians (SMD:0.287, 95% CI: 0.125-0.448, p = 0.001), Asians (SMD:1.500, 95% CI: 1.064-1.936, p < 10<sup>-4</sup>) and Africans (SMD: 8.386, 95% CI: 6.519-10.253, p < 10<sup>-4</sup>). Severe asthma cases showed markedly higher leptin level than that in mild asthma cases among overall populations (SMD:1.638, 95% CI: 0.952-2.323, p < 10<sup>-4</sup>) and Asians (SMD:2.600, 95% CI: 1.854-3.345, p < 10<sup>-4</sup>). No significant difference of leptin level between severe and mild asthma was observed in Caucasians (SMD:-0.819, 95% CI: -1.998-0.360, p = 0.173). Cumulative analyses yielded similar results regarding the difference of leptin status between asthma and non-asthma controls, as well as between severe and mild asthma cases among overall populations. Age and male/ female ratio were not associated with the difference of leptin status between asthma and non-asthma controls (coefficient:-0.031, 95% CI: -0.123-0.061, p = 0.495; coefficient:0.172, 95% CI: -2.445-2.789, p = 0.895), as well as between severe and mild asthma cases among overall populations (coefficient:-0.072, 95% CI: -0.208-0.063, p = 0.279; coefficient: 2.373, 95% CI: -0.414-5.161, p = 0.090). Asthma demonstrated significantly higher level of leptin than that in non-asthma controls among overall populations, Caucasians, Asians and Africans. Severe asthma cases showed markedly higher leptin level than that in mild cases among overall populations and Asians. Leptin may be a risk predictor and prognostic marker of asthma. Early monitoring and intervention of leptin may be needed for asthma.</p>","PeriodicalId":19470,"journal":{"name":"NPJ Primary Care Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10011586/pdf/","citationCount":"0","resultStr":"{\"title\":\"Predictive and prognostic value of leptin status in asthma.\",\"authors\":\"Juan Wang, Ruochen Zhu, Wenjing Shi, Song Mao\",\"doi\":\"10.1038/s41533-023-00332-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Asthma is closely associated with inflammation. We evaluated the predictive and prognostic value of leptin status in asthma. We searched the electronic databases for articles that determined the leptin level in asthma cases through May 2020. We compared the differences of leptin level between asthma and non-asthma controls, as well as between severe and mild asthma cases. We also investigated the impact of age and gender on these differences by using meta-regression analysis. 59 studies were included in our pooled analysis. Asthma cases demonstrated significantly higher leptin level than that in non-asthma controls among overall populations (SMD:1.061, 95% CI: 0.784-1.338, p < 10<sup>-4</sup>), Caucasians (SMD:0.287, 95% CI: 0.125-0.448, p = 0.001), Asians (SMD:1.500, 95% CI: 1.064-1.936, p < 10<sup>-4</sup>) and Africans (SMD: 8.386, 95% CI: 6.519-10.253, p < 10<sup>-4</sup>). Severe asthma cases showed markedly higher leptin level than that in mild asthma cases among overall populations (SMD:1.638, 95% CI: 0.952-2.323, p < 10<sup>-4</sup>) and Asians (SMD:2.600, 95% CI: 1.854-3.345, p < 10<sup>-4</sup>). No significant difference of leptin level between severe and mild asthma was observed in Caucasians (SMD:-0.819, 95% CI: -1.998-0.360, p = 0.173). Cumulative analyses yielded similar results regarding the difference of leptin status between asthma and non-asthma controls, as well as between severe and mild asthma cases among overall populations. Age and male/ female ratio were not associated with the difference of leptin status between asthma and non-asthma controls (coefficient:-0.031, 95% CI: -0.123-0.061, p = 0.495; coefficient:0.172, 95% CI: -2.445-2.789, p = 0.895), as well as between severe and mild asthma cases among overall populations (coefficient:-0.072, 95% CI: -0.208-0.063, p = 0.279; coefficient: 2.373, 95% CI: -0.414-5.161, p = 0.090). Asthma demonstrated significantly higher level of leptin than that in non-asthma controls among overall populations, Caucasians, Asians and Africans. Severe asthma cases showed markedly higher leptin level than that in mild cases among overall populations and Asians. Leptin may be a risk predictor and prognostic marker of asthma. 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引用次数: 0
摘要
哮喘与炎症密切相关。我们评估了瘦素在哮喘中的预测和预后价值。我们在电子数据库中搜索了截至2020年5月确定哮喘病例瘦素水平的文章。我们比较了哮喘组和非哮喘组、重度哮喘组和轻度哮喘组之间瘦素水平的差异。我们还通过meta回归分析调查了年龄和性别对这些差异的影响。我们的合并分析纳入了59项研究。哮喘患者瘦素水平在总体人群(SMD:1.061, 95% CI: 0.784-1.338, p -4)、高加索人群(SMD:0.287, 95% CI: 0.125-0.448, p = 0.001)、亚洲人群(SMD:1.500, 95% CI: 1.064-1.936, p -4)和非洲人群(SMD: 8.386, 95% CI: 6.519-10.253, p -4)中均显著高于非哮喘对照组。总体人群(SMD:1.638, 95% CI: 0.952 ~ 2.323, p -4)和亚洲人群(SMD:2.600, 95% CI: 1.854 ~ 3.345, p -4)中，重度哮喘患者瘦素水平明显高于轻度哮喘患者。白种人重度和轻度哮喘患者瘦素水平差异无统计学意义(SMD:-0.819, 95% CI: -1.998-0.360, p = 0.173)。累积分析得出了类似的结果，关于哮喘和非哮喘控制者之间瘦素状态的差异，以及总体人群中严重和轻度哮喘病例之间的差异。年龄和男女比例与哮喘对照组和非哮喘对照组瘦素水平差异无相关性(系数:-0.031,95% CI: -0.123 ~ 0.061, p = 0.495;系数:0.172,95% CI: -2.445-2.789, p = 0.895)，以及总体人群中重度和轻度哮喘病例之间的差异(系数:-0.072,95% CI: -0.208-0.063, p = 0.279;系数:2.373,95% CI: -0.414-5.161, p = 0.090)。在总体人群、高加索人、亚洲人和非洲人中，哮喘患者的瘦素水平明显高于非哮喘对照组。在所有人群和亚洲人中，严重哮喘患者的瘦素水平明显高于轻度哮喘患者。瘦素可能是哮喘的风险预测因子和预后标志。可能需要对哮喘进行瘦素的早期监测和干预。
Predictive and prognostic value of leptin status in asthma.
Asthma is closely associated with inflammation. We evaluated the predictive and prognostic value of leptin status in asthma. We searched the electronic databases for articles that determined the leptin level in asthma cases through May 2020. We compared the differences of leptin level between asthma and non-asthma controls, as well as between severe and mild asthma cases. We also investigated the impact of age and gender on these differences by using meta-regression analysis. 59 studies were included in our pooled analysis. Asthma cases demonstrated significantly higher leptin level than that in non-asthma controls among overall populations (SMD:1.061, 95% CI: 0.784-1.338, p < 10-4), Caucasians (SMD:0.287, 95% CI: 0.125-0.448, p = 0.001), Asians (SMD:1.500, 95% CI: 1.064-1.936, p < 10-4) and Africans (SMD: 8.386, 95% CI: 6.519-10.253, p < 10-4). Severe asthma cases showed markedly higher leptin level than that in mild asthma cases among overall populations (SMD:1.638, 95% CI: 0.952-2.323, p < 10-4) and Asians (SMD:2.600, 95% CI: 1.854-3.345, p < 10-4). No significant difference of leptin level between severe and mild asthma was observed in Caucasians (SMD:-0.819, 95% CI: -1.998-0.360, p = 0.173). Cumulative analyses yielded similar results regarding the difference of leptin status between asthma and non-asthma controls, as well as between severe and mild asthma cases among overall populations. Age and male/ female ratio were not associated with the difference of leptin status between asthma and non-asthma controls (coefficient:-0.031, 95% CI: -0.123-0.061, p = 0.495; coefficient:0.172, 95% CI: -2.445-2.789, p = 0.895), as well as between severe and mild asthma cases among overall populations (coefficient:-0.072, 95% CI: -0.208-0.063, p = 0.279; coefficient: 2.373, 95% CI: -0.414-5.161, p = 0.090). Asthma demonstrated significantly higher level of leptin than that in non-asthma controls among overall populations, Caucasians, Asians and Africans. Severe asthma cases showed markedly higher leptin level than that in mild cases among overall populations and Asians. Leptin may be a risk predictor and prognostic marker of asthma. Early monitoring and intervention of leptin may be needed for asthma.
期刊介绍：
npj Primary Care Respiratory Medicine is an open access, online-only, multidisciplinary journal dedicated to publishing high-quality research in all areas of the primary care management of respiratory and respiratory-related allergic diseases. Papers published by the journal represent important advances of significance to specialists within the fields of primary care and respiratory medicine. We are particularly interested in receiving papers in relation to the following aspects of respiratory medicine, respiratory-related allergic diseases and tobacco control:
epidemiology
prevention
clinical care
service delivery and organisation of healthcare (including implementation science)
global health.
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