Dora Jakus, Marijan Šitum, Petra Čepin, Ivana Vrhovac, Josip Anđelo Borovac
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The patients using AT had a smaller mean tumor size (2.98 vs 4.51 cm, P <0.001). A multivariable regression analysis, adjusted for age, sex, and number of comorbidities, showed a lower probability of having a high-grade cancer (OR 0.393, 95% CI 0.195-0.792, P = 0.009), T2 stage (OR 0.276, 95% CI 0.090-0.849, P = 0.025), and tumors larger than 3.5 cm (OR 0.261, 95% CI 0.125-0.542, P <0.001) in patients using AT.</p><p><strong>Conclusions: </strong>More favorable histopathological grades, stages, and smaller tumor sizes were found in patients with bladder cancer who experienced macroscopic hematuria and were using AT compared to patients not taking AT.</p>","PeriodicalId":9744,"journal":{"name":"Central European Journal of Urology","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/6d/CEJU-76-193.PMC10091894.pdf","citationCount":"0","resultStr":"{\"title\":\"The impact of antithrombotic therapy on the time of detection of bladder cancer.\",\"authors\":\"Dora Jakus, Marijan Šitum, Petra Čepin, Ivana Vrhovac, Josip Anđelo Borovac\",\"doi\":\"10.5173/ceju.2022.193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The aim of this article was to investigate the impact of chronic antithrombotic therapy (AT) use on the time of detection of bladder cancer, assuming that patients taking AT experience episodes of macroscopic hematuria earlier, and therefore have a more favorable histopathological grade and stage, as well as a smaller number and size of tumors compared to patients not taking AT.</p><p><strong>Material and methods: </strong>A retrospective, cross-sectional study was conducted, including 247 patients who underwent bladder cancer surgery for the first time at our institution during the three-year period (2019-2021) and who experienced macroscopic hematuria.</p><p><strong>Results: </strong>A lower frequency of high-grade bladder cancer (40.6% vs 60.1%, P = 0.006), T2 stage (7.2% vs 20.2%, P = 0.014), and a lower frequency of tumors larger than 3.5 cm (29% vs 57.9%, P <0.001) were found in patients using AT compared to patients not using them. 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引用次数: 0
摘要
前言:本文的目的是研究慢性抗血栓治疗(AT)的使用对膀胱癌发现时间的影响,假设服用AT的患者更早经历宏观血尿发作,因此具有更有利的组织病理学分级和分期,并且与未服用AT的患者相比,肿瘤的数量和大小更小。材料与方法:回顾性、横断面研究,纳入我院三年内(2019-2021年)首次行膀胱癌手术并出现宏观血尿的患者247例。结果:膀胱癌高级别(40.6% vs 60.1%, P = 0.006)、T2期(7.2% vs 20.2%, P = 0.014)、肿瘤大于3.5 cm的发生率较低(29% vs 57.9%, P)。结论:与未行AT的患者相比,有宏观血尿且行AT的膀胱癌患者有更有利的组织病理学分级、分期和更小的肿瘤大小。
The impact of antithrombotic therapy on the time of detection of bladder cancer.
Introduction: The aim of this article was to investigate the impact of chronic antithrombotic therapy (AT) use on the time of detection of bladder cancer, assuming that patients taking AT experience episodes of macroscopic hematuria earlier, and therefore have a more favorable histopathological grade and stage, as well as a smaller number and size of tumors compared to patients not taking AT.
Material and methods: A retrospective, cross-sectional study was conducted, including 247 patients who underwent bladder cancer surgery for the first time at our institution during the three-year period (2019-2021) and who experienced macroscopic hematuria.
Results: A lower frequency of high-grade bladder cancer (40.6% vs 60.1%, P = 0.006), T2 stage (7.2% vs 20.2%, P = 0.014), and a lower frequency of tumors larger than 3.5 cm (29% vs 57.9%, P <0.001) were found in patients using AT compared to patients not using them. The patients using AT had a smaller mean tumor size (2.98 vs 4.51 cm, P <0.001). A multivariable regression analysis, adjusted for age, sex, and number of comorbidities, showed a lower probability of having a high-grade cancer (OR 0.393, 95% CI 0.195-0.792, P = 0.009), T2 stage (OR 0.276, 95% CI 0.090-0.849, P = 0.025), and tumors larger than 3.5 cm (OR 0.261, 95% CI 0.125-0.542, P <0.001) in patients using AT.
Conclusions: More favorable histopathological grades, stages, and smaller tumor sizes were found in patients with bladder cancer who experienced macroscopic hematuria and were using AT compared to patients not taking AT.