慢性丙型肝炎患者接受直接抗病毒药物治疗后一些氧化应激标志物的可逆性

IF 3.5 4区 医学 Q2 IMMUNOLOGY Journal of Virus Eradication Pub Date : 2023-03-01 DOI:10.1016/j.jve.2023.100318
Pin-Nan Cheng , Hung-Yu Sun , I-Che Feng , Sin-Tian Wang , Yen-Cheng Chiu , Hung-Chih Chiu , Shih-Chieh Chien , Kung-Chia Young
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引用次数: 0

摘要

丙型肝炎(HCV)与肝外受累、发病率以及代谢变化相关。如果通过直接作用抗病毒(DAA)治疗实现持续病毒学反应(SVR),这些是否可能可逆仍然未知。方法慢性丙型肝炎(CHC)患者在2年随访期间接受DAA联合SVR治疗与HCV感染自发清除(SC)患者进行比较。评估血浆氧化应激标志物(氧化低密度脂蛋白(oxLDL)、8-羟基-2 ' -脱氧鸟苷(8-OHdG)、丙二醛(MDA)和缺血修饰白蛋白(IMA))以及肝纤维化进展。结果与SC个体相比,CHC组的oxLDL、8-OHdG和IMA基线水平较高,但MDA水平不高。SC组8- ohdl水平在svr后2年升高(p = 0.0409),而daa治疗的CHC组oxLDL水平下降(p <0.0001)和8-OHdG (p = 0.0255)水平接近SC组,但MDA水平升高(p = 0.0055)。此外,oxLDL水平与SVR (p = 0.017)和SVR后1年(p = 0.002)的肝脏硬度测量呈正相关。结论DAAs清除HCV病毒血症后血浆oxLDL出现svr后正常化,并与肝纤维化水平相关。
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Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents

Introduction

Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown.

Methods

Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated.

Results

Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8-OHdG and IMA but not of MDA. In the SC group, 8-OHdG levels were elevated at 2-year post-SVR (p = 0.0409), while the DAA-treated CHC group showed decrease in oxLDL (p < 0.0001) and 8-OHdG (p = 0.0255) levels, approaching those of the SC group, but increased MDA (p = 0.0055) levels. Additionally, oxLDL levels were positively correlated with liver stiffness measurements at SVR (p = 0.017) and at 1 year post- SVR (p = 0.002).

Conclusions

Plasma oxLDL showed post-SVR normalization after clearance of HCV viremia with DAAs and was associated with levels of hepatic fibrosis.

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来源期刊
Journal of Virus Eradication
Journal of Virus Eradication Medicine-Public Health, Environmental and Occupational Health
CiteScore
6.10
自引率
1.80%
发文量
28
审稿时长
39 weeks
期刊介绍: The Journal of Virus Eradication aims to provide a specialist, open-access forum to publish work in the rapidly developing field of virus eradication. The Journal covers all human viruses, in the context of new therapeutic strategies, as well as societal eradication of viral infections with preventive interventions. The Journal is aimed at the international community involved in the prevention and management of viral infections. It provides an academic forum for the publication of original research into viral reservoirs, viral persistence and virus eradication and ultimately development of cures. The Journal not only publishes original research, but provides an opportunity for opinions, reviews, case studies and comments on the published literature. It focusses on evidence-based medicine as the major thrust in the successful management of viral infections.The Journal encompasses virological, immunological, epidemiological, modelling, pharmacological, pre-clinical and in vitro, as well as clinical, data including but not limited to drugs, immunotherapy and gene therapy. It is an important source of information on the development of vaccine programs and preventative measures aimed at virus eradication.
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