权力的“转移”:DNA病毒感染与tRNA生物学的交叉

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-09-15 DOI:10.1016/j.semcdb.2023.01.011
Sarah E. Dremel , Ariana R. Jimenez , Jessica M. Tucker
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引用次数: 1

摘要

转移RNA(tRNA)是分子生物学中心法则的核心,其功能是将信使RNA解码为蛋白质。作为专性细胞内寄生虫,病毒依赖于宿主翻译机制,包括宿主tRNA。因此,病毒微调tRNA表达的能力激发了影响感染结果的能力。DNA病毒通常上调RNA聚合酶III(Pol III)依赖性转录物的输出,包括tRNA。在这些初步发现几十年后,我们对成熟的tRNA库在病毒感染期间如何变化知之甚少,因为tRNA测序方法最近才达到熟练程度。在这里,我们回顾了DNA病毒感染对tRNA生物发生的干扰,包括一种名为tRNA衍生片段(tRFs)的新兴参与者。我们讨论了tRNA失调如何改变宿主和病毒之间的权力格局,强调了基于tRNA的抗病毒药物作为未来治疗药物的潜力。
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“Transfer” of power: The intersection of DNA virus infection and tRNA biology

Transfer RNAs (tRNAs) are at the heart of the molecular biology central dogma, functioning to decode messenger RNAs into proteins. As obligate intracellular parasites, viruses depend on the host translation machinery, including host tRNAs. Thus, the ability of a virus to fine-tune tRNA expression elicits the power to impact the outcome of infection. DNA viruses commonly upregulate the output of RNA polymerase III (Pol III)-dependent transcripts, including tRNAs. Decades after these initial discoveries we know very little about how mature tRNA pools change during viral infection, as tRNA sequencing methodology has only recently reached proficiency. Here, we review perturbation of tRNA biogenesis by DNA virus infection, including an emerging player called tRNA-derived fragments (tRFs). We discuss how tRNA dysregulation shifts the power landscape between the host and virus, highlighting the potential for tRNA-based antivirals as a future therapeutic.

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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
期刊最新文献
Diverse genetic conflicts mediated by molecular mimicry and computational approaches to detect them Outside Front Cover Editorial Board/Publication Information From the cauldron of conflict: Endogenous gene regulation by piRNA and other modes of adaptation enabled by selfish transposable elements Outside Front Cover
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